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Multi-layer blood vessel stent and preparation method thereof

A vascular stent and inner tube technology, applied in the field of multi-layer vascular stent and its preparation, can solve the problems of lack of repairing blood vessel function, foreign body reaction of stent, single stent function, etc., so as to prolong antithrombotic time, promote healing and repair effect of blood vessels

Active Publication Date: 2018-11-23
乐普(深圳)国际发展中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most antithrombotic stents in the prior art are coated with antithrombotic drugs on the stent. For example, patent CN201320855841.1 discloses a new type of antithrombotic stent. The antithrombotic stent includes a first antithrombotic drug layer and a second antithrombotic drug layer. The second anti-thrombotic drug layer is to achieve anti-thrombosis through two layers of coatings loaded with anti-thrombotic drugs; The function is single, and it does not have the function of repairing blood vessels

Method used

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  • Multi-layer blood vessel stent and preparation method thereof
  • Multi-layer blood vessel stent and preparation method thereof
  • Multi-layer blood vessel stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (a) Add polylactic acid with a molecular weight of 900,000 Da into the extruder, extrude a pipe with a wall thickness of 0.2 mm, cut the pipe with a laser, and cut the wall of the pipe into a network structure to obtain the inner pipe 1, the inner pipe The inner diameter of 1 is 4 mm, the inner tube 1 is placed in the mold for preparing the support bar 2, the shape memory polymer in the molten state is added to the mold, cooled to room temperature, and dried, and the outer wall of the inner tube 1 is made into a support bar 2. A plurality of said shaped support bars 2 are radially distributed on the outer surface of the inner tube 1, the diameter of the support bars 2 is 0.05 mm, and the distance between adjacent support bars 2 is 0.5 mm; The solution of rapamycin is coated on the outer surface of the support bar 2 and dried; then the inner tube 1 is placed in the mold for preparing the outer tube 3, the shape memory polymer is added to the mold, cooled to room temperatu...

Embodiment 2

[0030] (a) Add polylactic acid with a molecular weight of 1 million Da into the extruder, extrude a pipe with a wall thickness of 0.2 mm, and cut the pipe with a laser to obtain an inner pipe 1 whose inner diameter is 4 mm. Place the mold for preparing the support bar 2, add the shape memory polymer in the molten state into the mold, cool to room temperature, dry, and make the support bar 2 on the outer wall of the inner tube 1, and a plurality of the shape memory polymers 2 Distributed radially on the outer surface of the inner tube 1, the diameter of the support bars 2 is 0.01 mm, and the distance between adjacent support bars 2 is 0.4 mm; subsequently, the solution loaded with rapamycin is coated on the support The outer surface of the bar 2 is dried; then the inner tube 1 is placed in the mold for preparing the outer tube 3, the shape memory polymer is added to the mold, cooled to room temperature, and dried, and the inner tube 1 is placed at the side of the support bar 2 f...

Embodiment 3

[0034](a) Add polylactic acid with a molecular weight of 900,000 Da into the extruder, extrude a pipe with a wall thickness of 0.1 mm, and cut the pipe with a laser to obtain an inner pipe 1 whose inner diameter is 3 mm. Place the mold for preparing the support bar 2, add the shape memory polymer in the molten state into the mold, cool to room temperature, dry, and make the support bar 2 on the outer wall of the inner tube 1, and a plurality of the shape memory polymers 2 Distributed radially on the outer surface of the inner tube 1, the diameter of the support bar 2 is 0.1 mm, and the distance between adjacent support bars 2 is 0.5 mm; subsequently, the solution loaded with rapamycin is coated on the support The outer surface of the bar 2 is dried; then the inner tube 1 is placed in the mold for preparing the outer tube 3, the shape memory polymer is added to the mold, cooled to room temperature, and dried, and the inner tube 1 is placed at the side of the support bar 2 far aw...

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Abstract

The invention discloses a multi-layer blood vessel stent. The blood vessel stent comprises a stent body, the stent body is provided with an inner tube, an outer tube and a plurality of supporting strips, the inner tube is sleeved with the outer tube, the supporting strips are radially disposed on the outer wall of the inner tube, one end of each supporting strip is connected to the outer wall of the inner tube, the other end of each supporting strip is connected to the inner wall of the outer tube, the inner wall of the inner tube is coated with a first coating, and the outer wall of the outertube is coated with a second coating. A method for preparing the multi-layered blood vessel stent comprises the steps of a, extruding polylactic acid into a tube material, conducting laser cutting, preparing the supporting strips on the outer wall of the inner tube, coating the outer surfaces of the supporting strips with rapamycin, conducting drying and preparing the outer tube at the ends, awayfrom the inner tube, of the supporting strips; b, coating the inner surface of the inner tube with heparin-based medicine and alumina water-soluble gel and then coating the surface of the first coating layer with the alumina water-soluble gel; c, conducting electrospinning on the outer surface of the outer tube for 1-2 hours to form the second coating of 5-10 micons.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a multilayer vascular stent and a preparation method thereof. Background technique [0002] Polymer stents mostly use polylactic acid as the base material, but polylactic acid will promote the formation of thrombus in the blood vessel; after most of the existing stents are placed in the blood vessel, the drug coating loaded on the stent is usually within 1 After the release is completed within a month, the intima of the blood vessel may not be fully repaired, and after the release of the drug, there is no drug at the stent, which further increases the probability of thrombus formation. [0003] Most antithrombotic stents in the prior art are coated with antithrombotic drugs on the stent. For example, patent CN201320855841.1 discloses a new type of antithrombotic stent. The antithrombotic stent includes a first antithrombotic drug layer and a second antithrom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/915A61L31/14A61L31/08A61L31/10A61L31/16A61L31/12
CPCA61F2/915A61F2002/91575A61F2210/0014A61F2240/001A61F2250/0067A61L31/08A61L31/088A61L31/10A61L31/14A61L31/16A61L2300/236A61L2300/412A61L2300/42A61L2300/45A61L2300/602A61L2300/606A61L2300/802A61L2400/16C08L5/10C08L89/00C08L67/04
Inventor 王刚王亮邹雪
Owner 乐普(深圳)国际发展中心有限公司
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