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Composite artificial minute vessel stent and preparation method thereof

A vascular stent and composite technology, applied in the field of composite artificial small vascular stents, can solve the problems of poor degradation rate, poor cell adhesion ability and proliferation activity, etc., achieve long strength maintenance time, appropriate degradation and absorption time, and inhibit vascular The effect of endothelial hyperplasia

Inactive Publication Date: 2012-06-13
WUXI NO 4 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the degradation rate of this material is poor, and the adhesion ability and proliferation activity of cells on it are poor. At present, many experiments focus on promoting the endothelialization of polyurethane surface.

Method used

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  • Composite artificial minute vessel stent and preparation method thereof
  • Composite artificial minute vessel stent and preparation method thereof
  • Composite artificial minute vessel stent and preparation method thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0017] figure 1 It is the artificial small blood vessel stent and its section after magnification 60 times. Electron microscope scanning of the cross-section of the vascular stent shows a three-layer structure, the outer layer is a stromal fiber layer (SIS), the middle layer is a polydioxanone woven mesh (PDS), and the inner layer is a collagen layer (Coll), and the reinforcement sutures are clear visible.

[0018] figure 2 It is an electron micrograph of the blended collagen-chondroitin sulfate sponge after magnification of 120 times. The inner surface of the scaffold is coated with blended collagen, and after freeze-drying, it has a sponge-like structure under an electron microscope, and the holes are the growth platforms for seeded cells.

[0019] The preparation method includes: ① Purchase the finished matrix fiber layer (SIS), and store it in phosphate buffer saline solution at 4°C. The purchased matrix fiber layer is 0.1mm thick and has good elasticity and strength....

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Abstract

The invention relates to a method for manufacturing an artificial vessel bracket, in particular a compound artificial small vessel bracket. The compound artificial small vessel bracket is characterized in that the small vessel bracket comprises three layers; a net tube-shaped fabric formed by using sutures to weave medical grade poly-p-dioxanone which is strong and elastic is taken as an intermediate elastic layer; a blending sulfuric acid chondroitin-collagen coating is used as an inner layer; an outer layer is wrapped in a matrix fiber layer, then is reinforced with the sutures, and subjected to compound molding; and a degradable small-caliber (4-5 mm) vessel bracket which is similar to a normal vessel in physicochemical and biomechanical property, and matched with the regeneration of self vessel tissue. The planting of seed cells on the inner surface of the vessel bracket to form an in vitro vessel provides theoretical principles and experimental basis for the clinical application of small-caliber tissue engineering vessels in coronary artery surgery and other fields.

Description

technical field [0001] The invention relates to a production method of an artificial vascular stent, in particular to a composite artificial small vascular stent. Background technique [0002] Coronary artery bypass grafting is currently one of the most effective methods for treating coronary heart disease. Commonly used materials for grafting blood vessels include the great saphenous vein, internal mammary artery, and radial artery. There are relatively abundant sources of veins, but the walls of the vessels are thin, poor in elasticity, and have disadvantages such as intimal hyperplasia and easy blockage. Considering the patency rate, as much arterial material as possible should be used, but the source of autologous arteries is limited. Currently, dacron and expanded polytet-rafluoroethylene (ePTFE), which are widely used in clinical practice, have disadvantages such as poor elasticity, poor compliance, and easy formation of thrombus (lack of intima). Vascular grafts, es...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61F2/82A61F2/06
Inventor 游庆军
Owner WUXI NO 4 PEOPLES HOSPITAL
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