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Auto-developing degradable vascular stent

A vascular stent and auto-imaging technology, which is applied in the field of auto-degradable vascular stents, can solve the problems of weak adhesion between the imaging layer and the stent, thrombosis, secondary injury to patients, etc. Load time, effect of reducing foreign body reaction

Active Publication Date: 2019-08-13
陕西兴泰生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the developing ring can only show the positions of the two ends of the stent, and cannot show the shape of the stent very well, which brings certain difficulties to the later follow-up observation
However, the development layer is not firmly attached to the bracket, and the development layer is easy to fall off in the later stage, which affects the observation
After the vascular stent is implanted in the body, it has a certain supporting effect on the blood vessel, but at the place where the vascular stent is implanted, thrombus and severe inflammatory reaction will occur, causing secondary damage to the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Inject the 200,000 Da L-polylactic acid macromolecule in molten state into the mould, cool and demould to obtain the blank of the stent body, clean the blank 3 times with alcohol, and then place the blank on In the gelatin aqueous solution, soak for 10 minutes, dry, make the surface of the blank adhere to a layer of gelatin, and make the stent body;

[0019] (b) Add L-polylactic acid to chloroform, stir evenly, add diatrizoate meglumine to the solution system to prepare a developing mixed solution, and spray the developing mixed solution on the preparation prepared in the above step (a) by ultrasonic atomization The support bar of the support body and the surface of the support ring away from the center of the support body are prepared as a developing layer, and then the support body is placed in the gelatin aqueous solution of the above step (a) to soak for 10 minutes and dried;

[0020] (c) Put the above-mentioned stent body on the stainless steel tube, fix...

Embodiment 2

[0022] Embodiment 2: Inject the L-polylactic acid macromolecule in the molten state into the mould, cool, and demould to obtain the blank of the stent body, clean the blank 3 times with alcohol, and then place the blank in an aqueous gelatin solution, Soak for 20min, dry, make the surface of the blank adhere to a layer of gelatin, and make the bracket body;

[0023] (b) adding L-polylactic acid to chloroform, stirring evenly, adding a developer to the solution system to prepare a developing mixed solution, and depositing the developing mixed solution on the stent body prepared in the above step (a) by plasma vapor deposition The surface of the support bar and the support ring away from the center of the bracket body is prepared as a developing layer, and then the bracket body is placed in the gelatin aqueous solution of the above step (a) to soak for 10 minutes and dried;

[0024] (c) Put the above-mentioned support body on the stainless steel tube, and fix the support body on...

Embodiment 3

[0026] Embodiment 3: Inject the L-polylactic acid macromolecule in molten state into the mould, cool, demould to obtain the blank of the stent body, clean the blank 3 times with alcohol, then place the blank in the gelatin aqueous solution, Soak for 10min, dry, make the surface of the blank adhere to a layer of gelatin, and make the bracket body;

[0027] (b) Add L-polylactic acid to the chloroform solution, stir evenly, add diatrizoate meglumine to the solution system to prepare a developing mixed solution, and prepare the developing mixed solution in the above step (a) by ultrasonic atomization and spraying The surface of the support bar of the stent body and the support ring away from the center of the stent body is prepared as a developing layer, and then the stent body is placed in the gelatin aqueous solution of the above step (a) to soak for 20min and dried;

[0028] (c) Put the above-mentioned bracket body on the stainless steel tube, fix the bracket body on the stainl...

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Abstract

The invention discloses an auto-developing degradable vascular stent. The auto-developing degradable vascular stent comprises a stent body, a developing layer, a first spinning layer and a second spinning layer; the developing layer is arranged on the outer surface of the stent body, the first spinning layer is wrapped around the outer side wall of the stent body, and the second spinning layer isarranged on the outer side of the first spinning layer. A preparation method comprises the steps of (a) preparing the stent body; (b) preparing a mixed developing solution and depositing the mixed developing solution on the surface of the stent body to prepare the developing layer; (c) spraying the first spinning layer onto the outer side wall of the stent body; (d) preparing the second spinning layer on the surface of the stent body, and pressing the stent body into a ball.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a degradable autoradiography vascular stent. Background technique [0002] Vascular stents made of degradable polymers can achieve the radial support strength of metal stents, and are also degradable. In the later stage of implantation, they can be degraded in vivo to avoid secondary operations. However, due to their own characteristics, polymer stents , cannot be visualized under X-rays. The existing developing method is to add a developing ring or coat a developing layer on the polymer stent, so that the polymer stent has the function of developing. However, the developing ring can only show the positions of the two ends of the stent, and cannot show the shape of the stent very well, which brings certain difficulties to the later follow-up observation. However, the development layer is not firmly attached to the support, and the development layer is easy t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82
CPCA61F2/82A61F2210/0004A61F2240/001A61F2250/0067A61F2250/0098A61F2310/0097
Inventor 杨媛陈果王亮王刚
Owner 陕西兴泰生物科技有限责任公司
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