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Nano magnesium/polylactic acid composite material for completely degradable endovascular stent and preparation method thereof

A completely degradable and composite material technology, which is applied in the field of nano-magnesium/polylactic acid composite materials, can solve the problems of fast corrosion of magnesium and shelving, and achieve the effect of reducing intimal hyperplasia, wide application prospects, and improving biological activity

Inactive Publication Date: 2012-07-04
ALLEN MEDICAL TECH SERVICE BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Early clinical applications have confirmed the feasibility of magnesium as a medical material, but later studies in this area were shelved because of the rapid corrosion of magnesium.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1. In an anaerobic operating room, weigh 10g of polylactic acid (with a molecular weight of 180,000, pharmaceutical grade), dissolve it in 100ml of 1,4-dioxane solvent, and add 2g of nano-magnesium (particle size 60nm), Stir uniformly to prepare a polylactic acid solution; pour the obtained polylactic acid solution into a self-made mold and freeze-dry for 24 hours in a vacuum to prepare a completely degradable intravascular stent.

Embodiment 2

[0018] Example 2. In an anaerobic operation room, weigh 8g of polylactic acid (with a molecular weight of 400,000, pharmaceutical grade), dissolve it in 100ml of 1,4-dioxane solvent, and add 2g of nano-magnesium (particle size: 50nm), Stir uniformly to prepare a polylactic acid solution; pour the obtained polylactic acid solution into a self-made mold and freeze-dry for 24 hours in a vacuum to prepare a completely degradable intravascular stent.

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Abstract

The invention relates to a nano magnesium / polylactic acid composite material for a completely degradable endovascular stent and a preparation method thereof. The preparation method comprises the following steps: blending and compositing nano magnesium which is used as a reinforcing material with polylactic acid so as to prepare the completely degradable endovascular stent. The stent has good compatibility with a human body, has less possibility of causing inflammatory reaction, can be completely degraded, and has the advantages of stable mechanical property, simple preparation method, low cost and the like.

Description

Technical field [0001] The invention relates to a nano-magnesium / polylactic acid composite material used for a completely degradable intravascular stent, belonging to the field of biomedical materials. Background technique [0002] Intravascular stents are one of the most effective methods to treat cardiovascular diseases. The stents currently used clinically are mainly permanent stents, including bare metal stents and drug-eluting stents (DES) based on stainless steel and cobalt-chromium alloys. Permanent stents can easily cause damage to the vascular intima, induce vascular intimal hyperplasia, and cause restenosis. Metal stents also have defects such as thrombosis, coagulation complications, flexion mismatch, and permanent retention of metal in the body to increase the occurrence of restenosis in the stent. The ideal design concept of the new generation of biodegradable stents is: for a period of time after intervention, the stent will mechanically support the blood vessel a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08K3/08A61L31/12A61L31/06A61L31/02
Inventor 徐力健周宏雷
Owner ALLEN MEDICAL TECH SERVICE BEIJING
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