35results about How to "Quality and safety controllable" patented technology

The invention discloses a ballast track laser intelligent track lifting and lining system. The ballast track laser intelligent track lifting and lining system comprises a track lifting and lining tamper (1) and is characterized by further comprising an integrated full-route measurement device, the full-route measurement device comprises a laser transmitting device (4) and an image receiving device (5), the image receiving device (5) is arranged on a front end image receiving trolley (7), and the laser transmitting device (4) is arranged on a laser transmitting movable trolley (2) in a distance. The image receiving device (5) is provided with a two-dimensional automatic tracking mechanism. A construction method includes the steps that route geometrical shape parameters are input, and track lifting and lining are conducted; each time the ballast track laser intelligent track lifting and lining system advances by a set distance, an electrical control system collects front end lifting and lining quantity data, a gva system outputs track lifting and lining quantity data control operation of an operation position, and the gva system feeds back track lifting and lining quantity data of an operation process. By means of the ballast track laser intelligent track lifting and lining system and the construction method, ballast track accurate track lifting and lining measurement workloads are greatly reduced, construction accuracy is improved, the advantages of the full-route measurement system and a large track maintenance machine are given into full play, and the problem of man-made errors occurring in the connection between the measurement procedure and the track lifting and lining construction procedure is thoroughly solved.

The invention relates to an acinetobacter baumannii A1S-1610 protein, a carrier, engineering bacteria, a composition or a kit which comprises the acinetobacter baumannii 1 A1S-1610 protein, and a preparation method and application of the acinetobacter baumannii 1 A1S-1610 protein, the acinetobacter baumannii 1 A1S-1610 protein is never used in the field of recombinant subunit vaccines, the acinetobacter baumannii 1 A1S-1610 protein can effectively stimulate the body to cause a protective immune response so as to resist acinetobacter baumannii lethal infection. The present invention also discloses a method for preparation of the recombinant protein by construction of an expression vector of the recombinant protein, and transformation of host bacteria, and use of the recombinant protein in the preparation of an acinetobacter baumannii resistant subunit vaccine and a related detection kit. The protective antigen composition A1S_1610 protein is expressed by use genetic engineering technology to clone, and the A1S_1610 protein is high in expression amount, easy to separate and purify, efficient and safe, and the genetic engineering recombinant subunit vaccine has good acinetobacter baumannii infection resistant immune protection effect.

The invention provides a fully-assembled steel-structure wading basic platform and a basic member thereof and particularly provides the on-site final-assembly construction of the steel-structure wading basic platform and the standardized design and scale production of a basic structural unit, i.e. a steel floating body (1), of the steel-structure wading basic platform. According to the fully-assembled steel-structure wading basic platform, the traditional wading infrastructures are subjected to improvement and innovation in the aspects of structural design and construction manner; the basic structural unit, i.e. the steel floating body (1), is subjected to standardized and definite-form design, so that the basic structural unit becomes a series finished product member which can be subjected to scale and mass production in factory workshops; and the construction of the fully-assembled steel-structure wading basic platform is quickly completed in a manner that steel floating body (1) series finished products are selected as required and are subjected to on-site final-assembly like building-block model building or tetris assembling (referring to a final-assembly diagrammatic drawing of the fully-assembled steel-structure wading basic platform in attached drawings). The fully-assembled steel-structure wading basic platform is applicable to but not limited by two platforms including near-water and on-water platforms of different functions and uses and platforms taking the near-water and on-water platforms as foundations of other on-water constructions, and can be widely applied to wading construction projects, such as ports, wharfs, transportation pontoons, aquaculture cages and on-water dining and entertainment platforms.

The invention discloses a cartilage graft and a construction method thereof. The cartilage graft is a cartilage membrane or injectable cartilage graft and contains a cartilage membrane or cartilage micro-tissue formed by in-vitro culture of cartilage cells.

The invention relates to the field of genetic engineering, and discloses PAL recombination protein of acinetobacter baumannii and a coding gene and application of the PAL recombination protein. The PAL recombination protein is (a) recombination protein as shown in SEQID NO:1 or SEQID NO:3; and (b) protein which is obtained by substituting, deleting and adding one or more amino acids for the aminoacid sequence as shown in SEQ ID NO:1 or SEQID NO:3, and has the same function as the recombination protein as shown in SEQID NO:1 or SEQID NO:3 and derived from (a) or protein which is prepared by connecting labels to the terminal of amino terminal and / or carboxyl terminal of the SEQID NO:1 or the SEQID NO:3 and shown in the amino acid sequence. The recombination protein is high in expression level, convenient to separate and purify, and high in efficacy and safe, can directly cooperate with an adjuvant for preparing a subunit vaccine and a relevant detection product, for resisting infectionof the acinetobacter baumannii.

The invention relates to an A1S-1462 recombinant protein and a preparation method and application thereof. The recombinant protein comprises A1S-1462 mature peptide, and the amino acid sequence of the recombinant protein is shown as SEQ ID NO. 3. The recombinant protein is high in expression amount, easy to separate and purify, efficient and safe, can be directly used with an adjuvant, and is used for the preparation of an acinetobacter baumannii infection resistant subunit vaccine and a related detection kit. Confirmed by animal experiments, the genetic engineering recombinant subunit vaccine has good acinetobacter baumannii infection resistant immune protection effect, lays a foundation for the further study on combined vaccines and multicomponent fusion vaccines, and plays an important role for development and application of prevention and control vaccines and diagnostic kits.

The invention discloses a pharmaceutical composition with effect on treating irritable bowel syndrome and a preparation method and an application thereof, and the pharmaceutical composition is prepared by the following raw material herbs by weight: 1-2 parts of red ginseng, 1-2 parts of athlets root skin, 1-2 parts of sargentodoxa vine, 1-2 parts of jujube, and 1-2 parts of coix seeds. The pharmaceutical composition provided by the invention is formulated based on traditional Chinese medicine theory and syndrome differentiation and treatment theory, and clinical experiment results show that the pharmaceutical composition provided by the invention has good effect on treating irritable bowel syndrome; extracts of the pharmaceutical composition provided by the invention can be prepared into various dosage forms with pharmaceutical carriers conveniently; the pharmaceutical composition is convenient for administration clinically, and has no toxic or side effect after long-term use.

The invention provides a method for detecting a white vein preparation. The white vein preparation comprises raw material medicines of pepper, liquorice and turmeric, and the method comprises the step of detecting the pepper, the liquorice and / or the turmeric through a thin-layer chromatography method. According to the detection method, the pepper, the liquorice and the turmeric in the prescription are detected and researched by the thin-layer chromatography method, the established thin-layer chromatography method has the advantages of high reproducibility, high stability, easy and convenient operation method, high precision, high specificity, clear spot color development, high degree of separation and the like; as a reliable quality detection method with high specificity is established, the quality of the white vein preparation can be effectively controlled; and the quality of the white vein preparation can be stable, safe and controllable.

The invention relates to the technical field of drug detection, and particularly discloses a method for detecting a residual solvent in antiangitide by using a gas chromatographic method and application. According to the method for detecting the residual solvent in antiangitide by utilizing the gas chromatographic method, the residual solvent is dimethyl sulfoxide, a direct sample injection mode is adopted, and a programmed heating mode is as follows: the initial temperature is 50-60 DEG C and is kept for 1-2 minutes; and heating is performed to 210-220 DEG C at the heating rate of 20 DEG C / min, the temperature is kept for 4-6 minutes, and the process is finished after 13-16 minutes. The gas chromatographic detection method is high in sensitivity and good in specificity, stability and accuracy, the quality of antiangitide can be effectively controlled, and the quality of antiangitide is stable, controllable and safe.

The invention relates to a purification method of anidulafungin. The purification method of anidulafungin comprises the steps of 1, dissolving and distaining, wherein, an anidulafungin crude product into a crystal solvent is added to make the solid completely dissolve, activated carbon is added to distain by stirring, and the dissolved solution is obtained after discoloring by filtering; 2, sampling the anidulafungin dissolved solution, loading the sample in macroporous adsorption resin, and increasing the pressure to wash the resin column with an acid or neutral water solution under the condition of 3-9bar; 3, concentrating, wherein, the eluent is concentrated until the eluent is dry, so that an anidulafungin pure product with content of more than 99.5% is obtained. The purification method of the anidulafungin is simple in technology, convenient to operate, and less in adopted amount of solution, and the isomer impurities with similar structural properties can be effectively removed. The product is high in purity and safe and controllable in quality, can be applicable to a refining method of the anidulafungin for industrial production, and the purity can be increased to 99.5% or above.

The invention discloses a clinical-grade serum-free culture medium for stem cells. According to the culture medium, an L-DMEM culture medium, an IMDM culture medium, a DMEM-F12 or alpha-MEM culture medium, an mTeSRTM1 culture medium, an E8 culture medium, a KSR conditioned culture medium and the like are used as basic culture media, and lipid substances such as inositol and linoleic acid and synthetic lipid substance components are removed; and meanwhile the culture medium contains the following added components: polyvinyl alcohol, bone morphogenetic protein BMP-4, vitamin C, retinoic acid, nicotinamide and azithromycin. The culture medium is clear in composition, controllable in quality and free of animal serum components, can be used for culturing various stem cells including pluripotent stem cells and multipotent stem cells, and can maintain the capability of stemness of the stem cells without differentiation after multiple passages.

The invention relates to a pharmaceutical composition of aminopyrimidine compounds and a preparation method thereof. Specifically, the pharmaceutical composition comprises 4-[(4-methyl-1-piperazinyl)methyl]-N-[6-methyl-5-[(4-(3-pyridyl)-2-pyrimidinyl)amino]pyridine-3-yl]-3-(trifluoromethyl)-benzamide, a polymorph, a solvate, a hydrate,pharmaceutically acceptable salt or a combination thereof whichare used as the active components, and at least a pharmaceutically acceptable accessory. The composition has good stability and drug dissolution; product quality is controllable; and the preparationmethod has simple process and strong operationality, and is suitable for industrial mass production.