The invention discloses a portable handheld ultrasonic welding machine with a protective structure, which relates to the technical field of welding machines and includes a main body and a base. cavity, the middle part inside the front end of the main body is provided with a control panel, and one end inside the control panel is installed with a connecting wire, the outer end of the connecting wire is provided with a welding head, and the base is located outside the bottom of the main body. The setting of the positioning groove and the built-in cavity can move the protective layer out of the built-in cavity during the long-term practical process, which is convenient for the user to clean the dust and other foreign objects blocked inside the protective layer, and can recycle the protective layer for practical use , it is more economical to use, and when installing the protective layer, the connecting protrusions on both sides of the protective layer can be used to snap into the inside of the positioning groove for fixing, so as to avoid that the protective layer is not stable enough during use.