The invention discloses a shaft end O-shaped permanent compression set resisting rubber sealing ring. Raw materials of the shaft end O-shaped permanent compression set resisting rubber sealing ring comprise, by weight, 30-60 parts of tetrapropyl fluoro rubber, 10-20 parts of nitrile butadiene rubber, 10-20 parts of polyether polyurethane rubber, 15-25 parts of styrene butadiene rubber, 1.2-2.5 parts of dicumyl peroxide, 2.5-4 parts of trimethylolpropane triacrylate, 0.8-1.7 parts of N,N'-p-phenylbimaleimide, 50-75 parts of modified nanometer montmorillonite, 20-45 parts of white carbon black, 20-40 parts of polytetrafluoroethylene, 5-12 parts of nanometer silica, 5-12 parts of nanometer kaolin, 5-12 parts of graphite powder, 5-12 parts of glass fibers, 0.8-1.6 parts of di(dioctylpyrophosphato)ethylene titanate, 0.9-1.8 parts of triphenyl phosphate, 0.9-1.8 parts of dibutyl phthalate, 0.9-1.8 parts of microcrystalline paraffin and 0.5-1.5 parts of an antioxidant.