31results about How to "Meet different clinical needs" patented technology

The present invention relates to biomedicine metal implant material, and is especially biomedicine implant material with controllable degrading rate and its application. The biomedicine implant material with controllable degrading rate has a magnesium or magnesium alloy matrix and a coated degradable polymer layer with thickness controlled within 0.01-5 mm. The biodegradation is completed step by step so as to ensure the mechanical performance of the material during degradation and match the degradation rate with the service period of the implanted device. The biomedicine metal implant material of magnesium or magnesium alloy may be used in preparing temporary or short term implanted device, such as degradable blood rack and peripheral rack, bone fracture plate and bone nail for inner fixing, tissue engineering rack, etc.

The invention provides a gelatin embolism microsphere and a preparation method and an application thereof. The preparation method of the gelatin embolism microsphere comprises the following steps of: (1) preparing a gelatin aqueous solution of which the concentration is 10-50 percent g / ml; (2) adding the gelatin aqueous solution prepared in the step (1) into an emulsifier-containing oil phase of which the temperature is 50-60 DEG C, stirring for 10 minutes, lowering the temperature to 2-5 DEG C, stirring for 30 minutes at the stirring speed of 100-900 revolutions per minute, and standing to precipitate the microsphere; (3) pouring the oil phase out, repeatedly washing the oil phase left on the surface of the microsphere with acetone, and filtering the microsphere out; and (4) adding the microsphere obtained in the step (3) into a crosslinking agent aqueous solution of which the pH is 8-9 and the concentration is 1-15 percent g / ml, reacting at the temperature of 4 DEG C for 0.5-25 hours, and washing the microsphere with distilled water. The gelatin embolism microsphere provided by the invention is crosslinked uniformly, is regularly spherical, and is convenient for screening grading and accurate marking of the particle diameter; and the degradation time and elasticity of the gelatin embolism microsphere are more suitable for clinical application.

The invention relates to lamivudine solid dispersion and a preparation method and a use of the lamivudine solid dispersion. The lamivudine solid dispersion provided by the invention is prepared by using a methoxy-terminated polyethylene glycol-polylactic acid block copolymer and derivatives of the block copolymer, polylactic acid, polylactic acid-glycolic acid copolymer or polycaprolactone as carrier materials by a hot melting method. The preparation method of the lamivudine solid dispersion provided by the invention avoids use of an organic solvent. The lamivudine solid dispersion provided by the invention can be applied in subcutaneous injection or intramuscular injection for treating chronic hepatitis B.

The invention provides a fibroin bone nail and a preparation method thereof. The preparation method of the fibroin bone nail comprises the following steps: firstly, preparing a fibroin solution; then concentrating the fibroin solution, drying in a mold, demolding, and implementing a cutting process so as to obtain a fibroin rod; finally, cutting the fibroin rod into a bone nail. By adjusting the molecular weight, curing parameters and molding means, the mechanical properties and the degradation speed of fibroin can be regulated and controlled, so that different clinical requirements are met. The fibroin bone nail provided by the invention is free of toxic and / or side effects, can be absorbed by human bodies and is excellent in mechanical property and free of chemical reagent with toxic and / or side effects in the preparation process, and conventional metal and polymer material bone nails can be replaced.

The invention discloses a bedside active exercise device for neurosurgery, comprising a base, the base is provided with a first protective tube, a second protective tube and a connecting shaft, and the first protective tube is provided with a first fixing hole , the second casing is provided with a second fixing hole, the second casing is provided with an extension block and a third fixing hole, the extension block is vertically fixed with a connecting rod and a connection hole, and the extension block An arc-shaped slide rail and an arc-shaped slide block are provided below the slide rail, an angle ruler is provided on the slide rail, fixing cards are provided in the chute on both sides of the slide block, and all The base is provided with an upper connecting block and a lower connecting block, the other end of the lower connecting block is connected with a supporting plate and a collar, and an elastic damping device is arranged between the collar and the connecting hole on the connecting rod. The device solves the problems of improving the safety of the upper limbs of the patient's voluntary activities, the workload of the nurses or family members assisting the contraction and stretching of the upper limbs of the patients, and the general effect of passive exercises.

The invention provides a traditional Chinese medicine pellet and a preparation method thereof, and particularly relates to a traditional Chinese medicine pellet preparation and a preparation method of the traditional Chinese medicine pellet preparation. The traditional Chinese medicine pellet preparation is prepared by six traditional Chinese medicines including radix astragali, fructus ligustri lucidi, hirudo, radix et rhizoma rhei, radix pseudostellariae and fructus lycii and other medical auxiliary materials. The traditional Chinese medicine pellet preparation contains a traditional Chinese medicine composition, a diluent and a disintegrant according to a specific ratio. The prepared pellet is obvious in moistureproof effect, high in pellet roundness and bioavailability, uniform in particle size distribution, relatively high in yield and excellent in drug release performance, and provides better selection for clinical medication.

The invention relates to an injectable composite bone cement with photothermal effect and its preparation method and application. The bone cement contains the following components in weight percent: 30-65% of biological glass powder, 5-30% of titanium nitride nano powder , sodium alginate mixed solution 30‑40%. Compared with the prior art, the bone cement of the present invention not only has the characteristics of being plastic and easy to operate, but also has a significant photothermal effect, which can be regulated by changing the amount of titanium nitride nanoparticles added; the bone cement prepared The process equipment of cement is simple, easy to operate, low in cost, good injectability can be obtained without adding cross-linking agent, and minimally invasive treatment can be realized; it can be used to prepare bone filler after surgical resection of bone tumor and applied to bone tissue Engineering bone repair, regeneration and other fields.

The present invention provides an implantable nerve stimulation device with multiple frequency modes, including a control circuit for determining the frequency modes, the frequency modes include independent frequency modes and the same frequency mode, and multiple frequency modes are provided in the independent frequency mode Different pulse frequencies, providing a unique pulse frequency in the same frequency mode; a signal output circuit, used to output multiple groups of pulse signals according to the multiple different pulse frequencies in the independent frequency mode, wherein different groups of The pulse frequencies of the pulse signals are different. In the same frequency mode, multiple groups of pulse signals are output according to the unique pulse frequency, wherein the pulse frequencies of each group of pulse signals are the same.

The invention relates to the technical field of biomedicine. The invention provides a method for preparing a spider silk protein bone nail. The preparation method of the spider silk protein bone nail comprises the following steps: (1) preparing a spider silk protein solution; (2) injecting the spider silk protein solution into a mold, methanol Or ethanol treatment and drying to obtain spidroin protein bone nails. The preparation method of the spider silk protein bone nail provided by the present invention is simple to operate and can be produced industrially. The spider silk protein bone nail prepared by it has the advantages of high strength, high toughness, lightness, ultraviolet resistance, and biodegradability. It is an amino acid and a polypeptide, which is non-toxic to the human body.