Preparation method of silk medical inner fixation device

Abstract

The invention provides a preparation method of a silk medical inner fixation device. The method comprises the following steps of performing physical degumming on opening cocoons to obtain fibroin; cutting the fibroin into fibroin particles; mixing the fibroin particles with a calcium chloride ternary system to obtain a fibroin solution; removing impurities from the fibroin solution; performing dialysis and flushing; lowering the temperature of the fibroin solution; performing high-speed low-temperature centrifugation treatment to obtain an impurity-free fibroin solution; using a polyethylene glycol solution for eliminating moisture in the impurity-free fibroin solution; then, performing concentration treatment; fixing the fibroin solution subjected to the concentration treatment into a medical inner fixation device substrate by a medical inner fixation deice mold and methyl alcohol; performing elution on the medical inner fixing device substrate by super-pure water; adding the materials into a vacuum pumping drying furnace to be dried so as to obtain the medical inner fixation device primary blank. The preparation method solves the problems that the existing medical inner fixationdevice cannot degrade; the harm is caused on the body after the degradation; the intensity is insufficient, and the like. The prepared medical inner fixing device has good compatibility in the human body tissues; no toxic and harmful effects are generated on the human body; the device belongs to the medical inner fixation device with good human body affinity and no immunological rejection reaction; different clinic requirements are met.

Description

technical field [0001] The invention relates to a medical internal fixation device, in particular to a method for preparing a silk medical internal fixation device. Background technique [0002] In today's medical background, bone repair has become a very common routine operation. The internal fixation materials commonly used in traditional bone repair operations are stainless steel, titanium alloy and some other alloy materials such as magnesium, zinc, tin, etc. These metal internal fixation materials The common advantages of fixation materials are high strength, rigidity, and good toughness. The disadvantage is that they need to be taken out by secondary operations, which will cause secondary injuries to patients in terms of economy, physiology, psychology, and daily life; Stress shielding, the specific impact mechanism is that due to the existence of high-rigidity fixtures, most of the stress originally acting on the local bone is borne by the fixtures, so that fracture h...

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the above-mentioned shortcomings of the prior art, the purpose of the present invention is to solve the problems of existing medical internal fixation devices such as non-degradable, degraded, harmful to the body, and lack of strength, and provide a product that can produce a product that has good compatibility with human tissue and is non-toxic to the human body. A preparation method of silk medical internal fixation device for toxic effect medical internal fixation device