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A kind of silk protein bone nail and preparation method thereof

A technology of silk protein and bone nails, which is applied in the field of silk protein bone nails and its preparation, can solve the problems of low compatibility with human tissue and insufficient strength of bone nails, and achieve good environment and human adaptability, good human affinity, The effect of good compatibility

Active Publication Date: 2020-06-23
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above, the purpose of the present invention is to provide a silk protein bone nail and its preparation method, which is used to solve the problems of insufficient bone nail strength and low compatibility with human tissue in the prior art

Method used

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  • A kind of silk protein bone nail and preparation method thereof
  • A kind of silk protein bone nail and preparation method thereof
  • A kind of silk protein bone nail and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Such as figure 1 As shown, the present invention provides a kind of preparation method of silk protein bone nail, and concrete preparation steps are:

[0042] First, step S1 is performed to prepare a silk protein solution.

[0043] The specific method for preparing the silk protein microneedle is:

[0044] 1) Heat the cocoons in sodium carbonate solution to degumming and form silk.

[0045] As an example, the concentration of the sodium carbonate solution is 0-100 g / L, and the mass ratio of the added cocoon to the sodium carbonate solution is 10:(1-100) g / L. The heating method is electric furnace heating or pressure cooker heating, the heating temperature is 50-120°C, and the heating time is 1s-1000h. By adjusting the process parameters of the degumming process, the molecular weight of silk protein can be controlled.

[0046] 2) Washing the silk in ultrapure water, repeating several times, and drying.

[0047] As an example, the washing in this step may be stirring w...

Embodiment 2

[0065] What this embodiment prepares is silk protein bone nail.

[0066] Such as Figure 2 ~ Figure 4 As shown, 1 is the silk protein solution, 2 is the silk protein rod, and 3 is the silk protein bone nail. The specific implementation steps include:

[0067] First execute step S1: figure 2 As indicated, silk protein solution 1 was prepared.

[0068] Specifically, in this embodiment, first, each portion of 10g silkworm cocoon is cut into pieces and placed in 4L of sodium carbonate solution with a concentration of 2g / L, heated to boil in an electric furnace and magnetically stirred at a speed of 200r / min, and the heating time is 0.5h .

[0069] Then, each portion of boiled silk is placed in 2L of ultrapure water, stirred, washed and kneaded dry, repeated 6 times, and then dried, the stirring speed is 200r / min, and the stirring time is 20min. The volume of ultrapure water changed each time is 2L, the drying method is 25°C and normal pressure (0.1MPa).

[0070] Next, immer...

Embodiment 3

[0079] What this embodiment prepares is silk protein bone nail.

[0080] Such as Figure 5 ~ Figure 8 As shown, 4 is vitamin D, 5 is the silk protein solution, 6 is the mixed solution of vitamin D and silk protein, 7 is the silk protein rod containing vitamin D, and 8 is the silk protein bone nail containing vitamin D. The specific implementation steps include:

[0081] First execute step S1: Figure 5 As shown, prepare silk protein solution 5.

[0082] Specifically, in this embodiment, first, each portion of 10g silkworm cocoon is cut into pieces and placed in 4L of sodium carbonate solution with a concentration of 2g / L, heated to boil in an electric furnace and magnetically stirred at a speed of 200r / min, and the heating time is 0.5h .

[0083] Then, each portion of boiled silk is placed in 2L of ultrapure water, stirred, washed and kneaded dry, repeated 6 times, and then dried, the stirring speed is 200r / min, and the stirring time is 20min. The volume of ultrapure water...

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Abstract

The invention provides a fibroin bone nail and a preparation method thereof. The preparation method of the fibroin bone nail comprises the following steps: firstly, preparing a fibroin solution; then concentrating the fibroin solution, drying in a mold, demolding, and implementing a cutting process so as to obtain a fibroin rod; finally, cutting the fibroin rod into a bone nail. By adjusting the molecular weight, curing parameters and molding means, the mechanical properties and the degradation speed of fibroin can be regulated and controlled, so that different clinical requirements are met. The fibroin bone nail provided by the invention is free of toxic and / or side effects, can be absorbed by human bodies and is excellent in mechanical property and free of chemical reagent with toxic and / or side effects in the preparation process, and conventional metal and polymer material bone nails can be replaced.

Description

technical field [0001] The invention belongs to the technical field of degradable bone nails and their preparation, and relates to a silk protein bone nail and a preparation method thereof. Background technique [0002] In medicine, bone nails are commonly used bone fixation devices in the bone repair process. Traditional bone nails are made of stainless steel, titanium and their alloy materials. These materials have the advantages of high strength and good toughness. The disadvantage is that after the patient recovers, a second operation is required to take out the metal bone nails, which brings pain to the patient. It is painful for the second time, and the cavity left after the second operation will also leave the patient with a potential risk of fracture. Traditional metal materials for fixing broken bones usually do not degrade, and compared with bones, metal screws have higher mechanical strength, which will cause differences in the force of the bones after a long tim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 陶虎柳克银史之峰毛颖陈亮
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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