Clogging of membrane by slime adhesion is efficiently prevented and stable treatment can be carried out for a long period of time at a low cost by a small amount of chemicals without the membrane deterioration and
trihalomethane formation even if applied to the water having a large number of
viable cell counts and having
water quality of harsh. The method comprises supplying water to be treated to a membrane separation apparatus 4, adding intermittently to the water to be treated a combined
chlorine agent comprising sulfamic compound, and repeating a non-addition feeding period in which water to be treated is supplied for 6-120 hours without addition of combined
chlorine agent, and an intermittent addition feeding period in which water to be treated is supplied for 0.5-40 hours under addition of a combined
chlorine agent at
biofilm exfoliating concentration in an early stage of
biofilm formation during the non-addition feeding period, wherein
viable cell count (log CFU / mL) of water to be treated is 3 or more, and the concentration of the combined chlorine agent in the water in the intermittent addition feeding period is 0.5-20 mg / L as total chlorine, and additive amount of the combined chlorine agent added in the intermittent addition feeding period is the amount in which R represented by the following Formula [4] is 3 or more.R=(Intermittent addition feeding period (h)×[1000×Intermittent addition concentration (mg-Cl / L)]2.5 / (Non-addition feeding period (h)3.0×10log CFU / mL) [4]