39results about How to "Large detection dynamic range" patented technology

The present invention provides a cell strain and a detection method for detecting the activity of an antibody-immune agonist conjugated drug. ‑Immune agonist receptors and immune signaling pathway reporter genes in immune agonist drug conjugates. The cell line of the present invention can be used for the activity detection of different target antigens and immune agonist conjugated drugs with different activity levels. The detection method of the present invention can overcome the shortcomings of the co-culture method of PBMC and antigen-positive cells, and has the advantages of simple operation, low cost, higher sensitivity, larger detection dynamic range, and the like, and the antibody obtained by the detection method of the present invention has the advantages of ‑The activity results of the immune agonist-conjugated drug are closer to the results of in vivo efficacy experiments.

An optical free-form surface full-band aberration detection system and detection method relate to the field of optical free-form surface detection and solve the contradiction between dynamic range and detection accuracy in existing optical free-form surface detection and the detection difficulties of optical free-form surface. It includes a mid-to-high frequency aberration detection system and a low-frequency aberration detection system; the mid-to-high frequency aberration detection system includes a mirror to be tested, a luminescent screen, and a CCD camera; the CCD camera includes a focal plane, a camera lens, and a pinhole; the low-frequency aberration The detection system includes an imaging lens, a beam splitting prism, an adjustable aperture, a fiber laser, a converging lens, an imaging camera, and a motorized translation stage; the invention adopts a computer-aided reverse Hartmann measurement method and a phase recovery method, and has high measurement accuracy , the dynamic range of the measurement slope is large, and the spatial resolution is high, and it can measure the large numerical slope problem that cannot be measured by the interferometer and the Hartmann detection.

The invention discloses a receiving signal strength indicating circuit with layout area reduced. The circuit comprises a subtractor, a limiting amplifier chain, a full-wave rectifier set, an output buffer and a direct-current offset extraction circuit. By adopting the novel direct-current offset extraction circuit, the layout area of the whole circuit is substantially reduced, integration level is improved, and cost is lowered. The receiving signal strength indicating circuit with the layout area reduced is simple in structure, stable and reliable in working, capable of being applied to low-intermediate-frequency and zero-intermediate-frequency receivers, and especially suitable for zero-intermediate-frequency application.

The invention discloses a cloth chip gravity / capillary flow chemiluminescence method, in particular discloses a cloth chip with gravity / capillary force coupling driving fluid and its application in detecting heavy metal ions. The cloth chip of the present invention is divided into a hydrophobic area and a hydrophilic area, and the hydrophilic area is further divided into three parts: a sampling area, a detection area and a fluid channel area; when in use, the cloth chip should be placed on a support closely, The inclined surface of the bracket forms an included angle with the horizontal plane. After placement, the sample loading area and fluid channel area should be on the inclined surface of the bracket, and the detection area should be on the horizontal part of the bracket. At the same time, a hydrophobic sheet should be placed under the detection area of ​​the cloth chip. Compared with traditional flow chemiluminescence, the cloth chip and detection method of the present invention do not need any expensive pump device (precision syringe pump, peristaltic pump, etc.) to drive liquid flow. The invention only drives the liquid flow through the natural gravity of the liquid and the capillary force of the cloth fiber gap.

The invention provides a phase-type SPR detection device and method based on interference spectrum. The device includes: a light source, a polarizer, a wave plate, an SPR sensing module, a spectrometer and a control terminal. The invention utilizes a wave plate with a certain thickness to delay the phase of the P-polarized light and the S-polarized light in the incident light, so that the phenomenon of spectral interference occurs; the SPR resonance wavelength and phase are analyzed in real time by performing a frequency domain-time domain joint algorithm on the interference spectrum. , the SPR phase extraction accuracy is improved; by obtaining the resonance wavelengths of samples with different refractive indices, the effective interference spectrum is obtained through the resonance wavelength, and then the SPR phase change is extracted from the effective interference spectrum, and the sample to be tested is obtained according to the SPR phase change. Compared with the traditional phase modulation SPR technology, SPR phase detection with a large dynamic range is realized without any modulator, which has the advantages of strong anti-noise capability and low R&D cost.

The invention provides a phase type SPR detection device and method based on white light interference spectrum. The device includes: a light source, a filter polarization module, a wave plate, an SPR sensing module, an area array detector and a control terminal. In the present invention, the wave plate is used to generate phase delay for the P-polarized light and S-polarized light in the incident light, and a spectral interference phenomenon occurs; in order to realize high-throughput sensing, an optical-frequency time-division multiplexing technology is adopted, and an area array detector is used to sense Surface imaging, obtain the white light interference spectrum of all sites, and analyze the white light interference spectrum in the frequency domain to obtain the resonance wavelength corresponding to samples with different refractive indices, and then select the effective sinusoidal interference spectrum through the resonance wavelength, and use the algorithm to obtain samples with different refractive indices in real time The corresponding phase change can obtain the molecular interaction information of the sample to be tested. By simultaneously monitoring the SPR phase change in different wave bands, the detection dynamic range can be expanded, and no external modulator is required to modulate the light wave, and the device structure is simple.

The invention discloses a partial discharge localization method based on electro-acoustic joint detection signal propagation delay compensation. The method firstly samples and extracts partial discharge ultra-high frequency electromagnetic waves and ultrasonic acoustic signals, and obtains electromagnetic wave pulses and ultrasonic waves generated by partial discharge sources. Acoustic pulse signal; then extract the propagation delay characteristics of the two signals respectively; take the propagation delay characteristic value of the electromagnetic wave signal as a reference to obtain the relative propagation delay of the ultrasonic signal, and carry out the relative propagation delay under the metal boundary condition. Correction and compensation; then calculate the distance between the partial discharge source and the ultrasonic sensor; repeat the sampling to calculate the distance between the partial discharge source and a single ultrasonic sensor, and use the arithmetic mean value of the distance as the final determined distance between the partial discharge source and the ultrasonic sensor; finally combine The electrical arrangement in the cabinet determines the specific location of the partial discharge source. The positioning method of the present invention can more accurately reflect the exact position of the partial discharge source of the equipment.