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A phase type SPR detection device and method based on white light interference spectrum

A technology of white light interference and interference spectroscopy, which is applied in the field of phase-type SPR detection devices, can solve the problems of complex structure of the device, high cost of high-throughput detection, and small dynamic range of SPR detection, and achieve the effect of simple structure of the device and expansion of the dynamic range

Active Publication Date: 2022-07-05
山东深大光学科技有限公司
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Problems solved by technology

[0005] In view of the deficiencies in the above-mentioned prior art, the object of the present invention is to provide a phase-type SPR detection device and method based on white light interference spectrum, which overcomes the need for an external modulator to modulate the light wave in the existing phase-modulated SPR detection device. The structure is complex, the cost of high-throughput detection is high, and SPR detects defects with a small dynamic range

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  • A phase type SPR detection device and method based on white light interference spectrum
  • A phase type SPR detection device and method based on white light interference spectrum
  • A phase type SPR detection device and method based on white light interference spectrum

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[0051] In order to make the objectives, technical solutions and advantages of the present invention clearer and clearer, the present invention will be further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

[0052] The structure diagram of the existing phase modulation SPR device is as follows figure 1 As shown, it includes: a laser 11, a modulator 12 for modulating the light beam generated by the laser 11, and a beam splitter 13 for splitting the modulated light beam. The beam splitter 13 divides the modulated beam into two beams, one beam directly passes through the polarizer 17 and is detected by the detector 18 as a reference beam, and the other beam passes through the prism 14 and is irradiated to the sensing film 15 in contact with the sample 16 to be tested. Above, the plasmon...

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Abstract

The invention provides a phase type SPR detection device and method based on white light interference spectrum. The device includes: a light source, a filter polarization module, a wave plate, an SPR sensing module, an area array detector and a control terminal. In the present invention, the wave plate is used to generate phase delay for the P-polarized light and S-polarized light in the incident light, and a spectral interference phenomenon occurs; in order to realize high-throughput sensing, an optical-frequency time-division multiplexing technology is adopted, and an area array detector is used to sense Surface imaging, obtain the white light interference spectrum of all sites, and analyze the white light interference spectrum in the frequency domain to obtain the resonance wavelength corresponding to samples with different refractive indices, and then select the effective sinusoidal interference spectrum through the resonance wavelength, and use the algorithm to obtain samples with different refractive indices in real time The corresponding phase change can obtain the molecular interaction information of the sample to be tested. By simultaneously monitoring the SPR phase change in different wave bands, the detection dynamic range can be expanded, and no external modulator is required to modulate the light wave, and the device structure is simple.

Description

technical field [0001] The invention belongs to the technical field of optical sensing and imaging, and in particular relates to a phase type SPR detection device and method based on white light interference spectrum. Background technique [0002] Surface plasmon resonance (Surface plasmon resonance, SPR) sensing technology has the advantages of label-free, real-time monitoring, low sample consumption, high sensitivity and high-throughput detection, and is widely used in environmental monitoring, food safety, genomics and proteomics research. and other fields have a wide range of applications. SPR is an optical phenomenon. Under certain conditions, light is incident on some metal surfaces and undergoes total reflection. The evanescent wave of the incident light incident on the metal resonates with the surface plasmon wave on the metal surface. The resonance conditions and the metal film surface Different types of SPR sensors are generated by identifying different resonant o...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/552G01N21/45G01N21/27G01N21/25G01N21/01
CPCG01N21/553G01N21/45G01N21/27G01N21/255G01N21/01G01N2021/0112G01N2021/458
Inventor 邵永红糜晏瑞彪曾佑君王雪亮屈军乐
Owner 山东深大光学科技有限公司
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