The invention relates to a constant-current complementary current drive and control circuit of a high-power semiconductor laser device for drive and control of the high-power semiconductor laser device, and belongs to the field of electronic and optoelectronic industries. The constant-current complementary current drive and control circuit comprises functional circuits such as a laser current control circuit, a laser current feedback circuit, a laser current sampling resistor, a laser current MOSFET (metal oxide semiconductor field effect transistor), the semiconductor laser device, an external modulating signal circuit, a compensating current control circuit, a compensating current feedback circuit, a compensating current sampling resistor, a compensating current MOSFET and a compensating loop load. The constant-current complementary current drive and control circuit has the advantages that the stability of output current of a high-power and high-current semiconductor laser driver is improved greatly, total output current of the semiconductor laser driver is in a constant-current state through an external high-frequency modulation signal, and fluctuation of total current of a power supply is reduced, so that the stability and the reliability of the whole laser device driver are improved.