The invention discloses a substation secondary system operation and maintenance cloud platform, comprising in-place layers and a centralized control layer, which are configured to read data from a production management system directly to realize equipment management, operation management, fault handling, duty management and maintenance management. The in-place layers and the centralized control layer exchange power grid operation data by means of a dispatching data network, and exchange operation and maintenance management data by means of an integrated data network; each in-place layer comprises a substation control layer, a spacing layer and a process layer; each process layer comprises all primary equipment of a substation, and transmits information of the primary equipment of the present layer to the substation control layer by means of corresponding detection equipment; and each spacing layer comprises all secondary equipment of the substation, and transmits information of the primary equipment of the present layer to the substation control layer by means of corresponding detection equipment. The substation secondary system operation and maintenance cloud platform integrates the cloud computing technology, the big data technology, the Internet of things technology and the mobile internet technology, unifies data interfaces and dispatching among different secondary operation and maintenance systems in safety regions, and realizes good management of operation and maintenance information.