The invention provides a train full-automatic running method and system. The train full-automatic running method comprises the following steps that according to a running schedule or a command of a control center, trains are automatically awakened, and static detection and dynamic detection are completed; a parking lot control system performs route arrangement on the trains which are automatically awakened; the control center monitors the condition of the trains, the condition of the parking lot control system and the condition of an equipment centralization station, and controls and adjusts the running plan of each train combining the running schedule; when the trains need cleaning, a train washing machine sub system of the parking lot control system arranges a route for the trains to enter the train washing machine and a reentrant route for the trains to leave from the train washing machine; and when the trains stop running, automatic train protection ATP equipment and automatic train operation ATO equipment are closed, and AOM is kept working continuously. Compared with a conventional CBTC system, the train full-automatic running method disclosed by the invention realizes full-automatic running, the reliability, the safety, the availability and the maintainability of the train full-automatic running system are further improved, the operating emergency handling level is improved, the automation level is improved, and the labor strength is reduced.