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39results about How to "Improve cell affinity" patented technology
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Multiplex composite bone tissue engineering bracket material capable of degrading gradiently and preparation method thereof
The invention discloses a multiplex composite engineering scaffold material capable of gradually decomposing bone tissue and a preparation method thereof. The composite scaffold material consists of calcium phosphate bone cement, biological compatible degradable synthetic high polymer and biological compatible degradable natural high polymer, has better mechanical property and gradient degradation characteristic, and can achieve the aim of regenerating and repairing bone tissue defect by implanting a bone growth factor to induce in-vivo stem cells to be differentiated into bone cells, thereby obviously improving initial strength and toughness of the scaffold material, and ensuring enough strength and toughness of the scaffold material during operating and implanting. After compounded with the high polymer material, the scaffold has excellent flexibility, so that the scaffold can be subjected to certain machining, such as cutting and the like.
Owner:SOUTH CHINA UNIV OF TECH
Chitosan modified alginate hydrogel three-dimensional porous bracket and preparation method thereof
InactiveCN101773683ARich sourcesControllable physical and chemical propertiesProsthesisPhosphateFreeze-drying
The invention relates to a chitosan modified alginate hydrogel three-dimensional porous bracket with specific in-vitro degradability and a preparation method thereof. The method comprises the following steps: dissolving sodium alga acid serving as a raw material in phosphate buffer solution; performing amidation reaction of a carboxyl group in the sodium alga acid and an amino group in a cross-linking agent cystamine or dimethyl cystinate under the activation of water-soluble carbodiimide to form a chemically crosslinked hydrogel; performing freeze drying on the hydrogel to obtain a porous bracket material of the hydrogel; and performing surface modification on the porous bracket by using chitosan. In solution of a reducing agent such as cysteine with an appropriate concentration, a disulfide bond in a hydrogel cross-bridge is degraded through a disulfide bond-sulfydryl conversion reaction, so the porous bracket is decomposed and dissolved and disappears. Therefore, the porous bracket can be used as an in-vitro cell culture template material. The hydrogel porous bracket researched by the invention has the characteristics of simple preparation, rich raw material source, low cost and availability. Various physiochemical performances, mechanical strength, degradation rate and surface properties of the bracket material are controllable within a large range.
Owner:TIANJIN UNIV
Novel double-layered composite transmitting tissue regeneration membrane and preparation method thereof
The invention relates to a novel double-layered composite transmitting tissue regeneration membrane and a preparation method thereof. The double-layered composite transmitting tissue regeneration membrane consists of a PLGA / hydroxyapatite nonporous dense membrane on the outer layer and a PLGA / woolen keratin electrostatic spinning porous membrane on the inner layer. By means of a solvent casting method and a high-voltage electrostatic spinning method, the synthetic material PLGA is combined with the natural component woolen keratin and the inorganic component hydroxyapatite to form the composite material which supplement each other with respective advantages, thereby forming the PLGA / hydroxyapatite / woolen keratin double-layered composite transmitting tissue regeneration membrane. The double-layered composite transmitting tissue regeneration membrane disclosed by the invention is simple in preparation method and moderate in membrane forming conditions, has a good cell biocompatibility, conforms to the requirement of application in the living organism, and has a good application prospect as a novel transmitting tissue regeneration membrane.
Owner:NINGXIA MEDICAL UNIV
Method for preparing flamazine/bacterial cellulose composite wound dressing
ActiveCN101905031ABroad spectrum antibacterialStrong antibacterial activityAbsorbent padsBandagesWound dressingMoisture absorption
The invention provides a method for preparing flamazine / bacterial cellulose composite wound dressing, which comprises the following steps of: performing pretreatment and purification treatment on a bacterial cellulose membrane to obtain purified bacterial cellulose; preparing flamazine suspension with the granularity of 50 to 5,000 nm under dark condition; reacting the bacterial cellulose membrane with the flamazine suspension to form a flamazine / bacterial cellulose composite membrane; and performing drying treatment to obtain a dry flamazine / bacterial cellulose composite membrane, or performing extruding dehydration to obtain a wet flamazine / bacterial cellulose composite membrane with different water content values to prepare the flamazine / bacterial cellulose composite wound dressing. The prepared flamazine / bacterial cellulose composite wound dressing has high mechanical performance, high antibacterial property, and high water and air permeability or good drainage and moisture absorption effects, can promote the drying, scabbing and healing of wound, and is used for preventing and treating the secondary wound infection of second-degree and third-degree burn or scald.
Owner:UNIV OF SCI & TECH BEIJING +1
Diamine modified poly-latic acid, method for preparing same and use thereof
A diamine modified polylactic acid, its preparing process and its application in preparing the biodegradable medical materials, especially the tissue engineering material, are disclosed. Its advantages are excellent hydrophilicity and neutral degradation.
Owner:CHONGQING UNIV
Poly alpha-alcohol acid ester/chitosan ultrafine fiber hybridization film material and its preparation
A poly alpha alcohol acid ester / chitosan superfine fiber hybridization material and the preparation process thereof are disclosed. It belongs to tissue repairing material technology. The film having thickness of 10ª–m-50ª–m is formed by poly alpha alcohol acid ester fiber, the diameter of which being 50nmí½500nm, chitosan, the mass percent of which is 10-90%, polyvinyl alcohol or polyoxyethylene, the diameter thereof being 50nmí½500nm. The preparation process is as follows: dissolving PLA or PLGA into N,N- dimethytoluamide to prepare poly alpha alcohol acid ester spinning solution with concentration being 20%-25%, dissolving chitosan to acetic acid aqueous solution, adding polyvinyl alcohol or polyoxyethylene to solution to prepare for chitosan spinning solution with concentration 4%-8%, injecting said spinning solutions separately to the multi-channel electrostatic spinning device, conduct simultaneously electrostatic spinning and film converging in separate channels to prepare for film, with the voltage being 5kVí½30kV, liquid inventory being 0.1mL / hí½0.5mL / h, receiving range being 5cmí½25cm. The film has advantages of large water absorption, regulatable degrading rate and favorable cellular affinity.
Owner:TIANJIN UNIV
Copolymer of fibroin and poly D,L-lactic acid, preparation method and application thereof
The invention discloses a copolymer of fibroin and a poly D,L-lactic acid. The molecular weight of the copolymer having the structure is 5,000 to 180,000, and the mass ratio of the fibroin chain segment and the poly L-lactic acid chain segment is 0.5 / 99.5-99 / 0.5. The invention also discloses a solid phase polymerization preparation method thereof, the application thereof in biomedical materials, nano material thereof and a preparation method of nano materials. Copolymer of fibroin and poly D,L-lactic acid is prepared by adopting melt ring opening polymerization, and solvent is not used in the synthesis technique; therefore, the invention has the advantages that the process is simple, and the product cost is low. Through the invention, copolymer of fibroin and poly D,L-lactic acid with different number average molecular weight can be prepared. Copolymer of fibroin and poly D,L-lactic acid prepared by the invention can improve the hydrophilicity, the biocompatibility and the cellualar affinity of lactic acid material and control the degradation speed of the material.
Owner:NANJING FORESTRY UNIV
Absorbable medical suture line with good mechanical performance
ActiveCN105079869AImprove mechanical propertiesHigh strengthSuture equipmentsLactidePolyethylene glycol
The invention discloses an absorbable medical suture line with good mechanical performance. The absorbable medical suture line comprises, by weight, 100-120 parts of modified polylactic acid, 20-40 parts of polyglycollide, 4-6 parts of sorbitol, 3-5 parts of methyl methacrylate and 5-6 parts of cassia oil. The preparation method of the modified polylactic acid includes: in ice-bath, adding chitosan into perchloric acid, well mixing, dripping sorbic acid chloride, stirring, cooling, preserving heat and purifying to obtain modified chitosan; taking polyethylene glycol, feeding inert gas, heating, preserving heat until the polyethylene glycol melt, adding stannous chloride and lactide, well mixing, heating, preserving heat and stirring, and purifying to obtain intermediate material; dissolving the modified chitosan in mixed solvent, adding triethylamine, well mixing, heating, refluxing, adding the intermediate material, well mixing, continuing refluxing, purifying and drying to obtain the modified polylactic acid.
Owner:安徽省康宁医疗用品有限公司
Nano bone biomimetic material containing tussah silk fibroin, and preparation method thereof
InactiveCN102188753AGood biocompatibilityImprove biological activityProsthesisPorosityBone structure
The invention discloses a nano bone biomimetic material containing tussah silk fibroin, which is prepared from hydroxyapatite, tussah silk fibroin and chitosan, wherein the mass ratio of the hydroxyapatite to the tussah silk fibroin to the chitosan is 1:(0.1-0.5):(0.1-0.5). The porous nano bone biomimetic material containing tussah silk fibroin obtained by the invention has a big amount of intercommunicated micropores of the nano level, and has a higher porosity; the components containing the bone biomimetic material have good biological compatibility and structurally simulate the bone structure; and the hydroxyapatite / tussah silk fibroin nano compound particles are of the nano level and form strong binding force with the chitosan. The bone biomimetic material disclosed by the invention has good mechanical property, good formability and reasonable porosity, and can be used as an implanted degradable bone repair material.
Owner:ZHONGYUAN ENGINEERING COLLEGE
Chitose nanometer ultrafine fibre film material and its preparation method
InactiveCN1238061CLarge liquid absorptionImprove cell affinityProsthesisTissue repairPolyethylene oxide
A nanometer superfine chitosan fibrous membrane material and its preparation process are disclosed. It belongs to tissue repair material technology. The film material with the diameter being 10 mu m-50 mu m, is made by chitosan with mass percent of 10-90% and polyvinyl alcohol or polyethylene oxide superfine fiber with diameter of 50nm -500nm The preparation process is: dissolving chitosan to acetic acid solution, adding PVA pr PEO into the solution, the mass ratio of chitosan with PVA / PEO being 10 / 90-90 / 10, injecting the prepared 4%-8% spinning solution to the electrostatic spinning device for spinning to film material, therein, voltage being 5kV-30kV, liquid inventory being 0.1mL / h-0.5mL / h, receiving range being 5cm-25cm. The advantages of the invention: large volume absorbing ability, favorable cell affinity, capable of degrading in vivo and promoting defect tissue repairing when the film material is utilized as artificial skin or artificial cartilage. In addition, the preparation process is simple.
Owner:TIANJIN UNIV
Copolymer of fibroin and poly L-lactic acid, solid phase polymerization preparation method and application thereof
The invention discloses a copolymer of fibroin and a poly L-lactic acid. The molecular weight of the copolymer having the structure is 5,000-200,000, and the mass ratio of the fibroin chain segment and the poly L-lactic acid chain segment is 1 / 99-99 / 1. The invention also discloses a solid phase polymerization preparation method thereof and the application thereof in biomedical materials. The invention adopts the method of direct polymerization, the copolymer of fibroin and the poly L-lactic acid is prepared through main body melt / solid phase polymerization, and solvent is not used in the synthesis technique; therefore, the invention has the advantages that the process is simple, the product cost is low, the production cycle is short, and no pollution is generated. Through the invention, copolymer of fibroin and poly L-lactic acid with different number average molecular weight can be prepared, with the molecular weight of 5,000-200,000. Copolymer of fibroin and poly L-lactic acid prepared through the invention can improve the hydrophilicity, the biocompatibility and the cellualar affinity of lactic acid material and control the degradation speed of the material.
Owner:NANJING FORESTRY UNIV
Copolymer of fibroin and poly L-lactic acid, preparation method thereof through ring-opening polymerization and application thereof
The invention discloses a copolymer of fibroin and poly L-lactic acid, which comprises the following structure. The invention also discloses a preparation method for the copolymer through ring-opening polymerization and application of the copolymer in biomedical materials. The preparation method comprises the following steps of: preparing the copolymer of the fibroin and the poly L-lactic acid by performing the ring-opening polymerization on L-lactide in a molten state and performing copolymerization with the fibroin; and adopting solid phase polymerization to perform post condensation polymerization so as to further improve the molecular weight of the copolymer, reduce the contents of a monomer and a low molecular weight polymer in the system, and prepare a copolymer with narrow molecular weight distribution. A solvent is not used in the polymerization process, so the process is simple and the product cost is low. The preparation method can prepare the copolymers of the fibroin and poly the L-lactic acid with different number-average molecular weights. The copolymer of the fibroin and poly the L-lactic acid prepared by the method can improve the hydrophilic property, the biocompatibility and the cellular affinity of a polylactic acid material, and control the degrading speed of the material.
Owner:NANJING FORESTRY UNIV
Preparation method and application of bionic composite nanofiber stent material
InactiveCN110882416AHigh mechanical strengthGood toughness strengthPharmaceutical delivery mechanismProsthesisCell-Extracellular MatrixBiocompatibility
The invention relates to a preparation method and application of a bionic composite nanofiber stent material. The material comprises an artificial nanofiber scaffold material and an extracellular matrix material derived from cells. According to the composite nanofiber material disclosed by the invention, advantages of no toxicity, degradability and the like of the traditional L-polylactic acid biomedical material are reserved and mechanical properties such as the flexibility and the tensile strength of the stent material are also improved; since the extracellular matrix has high conservative property among different species, decellularized extracellular matrix stent has advantages of low immunogenicity, excellent biocompatibility and the like; and the mesenchymal stem cells that are goingto be implanted into the body of a patient and are amplified can be inoculated and thus a tissue engineering prosthesis stent for being implanted into the human body to replace defective tissues is formed after proper culturing.
Owner:DONGHUA UNIV
Preparation method of bioactive polylactic acid its product and application
InactiveCN1255451CBiological activity hasBiodegradableSurgeryPharmaceutical non-active ingredientsPolyethylene oxideHydroxylamine
A process for preparing a bioactive polylactic acid from the maleic acid anhydride modified polylactic acid includes directly adding organic diamine, diol, hydroxyamine, or water, reacting, separating and purifying the resultant, adding polyethanediol and bioactive substance, and reacting under action of organic cross-linking agent to obtain target product. The target product can be used as the scaffold of tissue engineery and the slow-releasing target carrier of medicine.
Owner:潘君
Preparation method of absorbable medical suture with good tensile strength
ActiveCN105063799AImprove hydrophilicityGood compatibilitySuture equipmentsConjugated synthetic polymer artificial filamentsLactideDissolution
The invention discloses a preparation method of an absorbable medical suture with good tensile strength. Inert gas is fed into ethylene glycol monomethyl ether, the ethylene glycol monomethyl ether is heated, the temperature is kept until the ethylene glycol monomethyl ether is molten, zinc lactate and lactide are added, the mixture is evenly mixed, heated, kept at the temperature, stirred and purified, and an intermediate material is obtained; carboxymethyl chitosan is added to water for dissolution, the intermediate material and stannous chloride are added and evenly mixed, inert gas is fed, the mixture is heated, kept at the temperature and purified, and modified chitosan is obtained; the modified chitosan, diisopropyl carbodiimide, glucose and cassia oil are evenly mixed, and the absorbable medical suture with the good tensile strength is prepared with a melt spinning method. The prepared suture is good in tensile strength, easy to knot, high in mechanical performance and well compatible with biological tissue, and cells adhere and reproduce on the prepared suture easily.
Owner:安徽省康宁医疗用品有限公司
Copolymer of fibroin and poly L-lactic acid and preparation method and application thereof
InactiveCN101717515AImprove hydrophilicityGood biocompatibilityPharmaceutical containersMedical packagingMolten statePolymer science
The invention discloses a copolymer of fibroin and poly L-lactic acid, which comprises the following structure. The invention also discloses a preparation method for the copolymer through melt polymerization and application of the copolymer in biomedical materials. The preparation method comprises the following steps of: preparing a prepolymer of the poly L-lactic acid by performing ring-opening polymerization on L-lactide in a molten state; and performing melt / solid phase copolymerization with the fibroin to prepare the copolymer of the fibroin and the poly L-lactic acid. The molecular weight of the prepolymer of the poly L-lactic acid can be controlled precisely to obtain a block polymer with different L-lactide chain segment lengths from short chains to long chains. A solvent is not used in the polymerization process, so the process is simple and the product cost is low. The preparation method can prepare the copolymers of the fibroin and poly the L-lactic acid with different number-average molecular weights. The copolymer of the fibroin and poly the L-lactic acid prepared by the method can improve the hydrophilic property, the biocompatibility and the cellular affinity of a polylactic acid material, and control the degrading speed of the material.
Owner:NANJING FORESTRY UNIV
Preparation method of ethylenediamine and RGD polypeptide modified MPLGA with high anhydride content
InactiveCN106366304AAlleviate the accumulation phenomenonWide range of regulationEthylenediamineRoom temperature
The invention provides a preparation method of ethylenediamine and RGD polypeptide modified MPLGA with high anhydride content. With D,L-lactide, glycolide and maleic anhydride being raw materials, stannous octoate being a catalyst and benzoyl peroxide being an initiator, the maleic polylactide glycolide anhydride (MPLGA) with the high anhydride content is prepared through polymerization under vacuum conditions; a trichloromethane solution of ethylenediamine is added into a trichloromethane solution of MPLGA under stirring conditions, the mixture is kept warm for 5-10 minutes at the temperature lower than 10DEG C and reacts for 30-60 minutes at room temperature, the product is dropwise added into an excessive solvent to precipitate and be separated out, and polymer (EMPLGA) solids of ethylenediamine modified MPLGA are obtained; the EMPLGA is dissolved in tetrahydrofuran, a coupling agent, namely N,N-dicyclohexylcarbodiimide, is added, the pH value of the solution is adjusted to range from 8 to 9, stirring is carried out, a tetrahydrofuran solution of RGD is dropwise added, the mixture reacts for 24 hours at the temperature of 0 DEG C and then is filtered, and the polypeptide modified RGD-EMPLGA solids are obtained after the product is frozen and dried. The prepared product has better hydrophilia, cell affinity and a controllable degradation property.
Owner:HUNAN UNIV OF SCI & TECH
A kind of preparation method of absorbable medical suture thread with good tensile strength
ActiveCN105063799BImprove hydrophilicityGood compatibilitySuture equipmentsConjugated synthetic polymer artificial filamentsPolymer scienceLactide
The invention discloses a preparation method of absorbable medical suture with good tensile strength. Polyethylene glycol monomethyl ether is taken, inert gas is introduced, the temperature is raised, and the temperature is kept until the polyethylene glycol monomethyl ether melts, and zinc lactate is added. , lactide, mix evenly, heat up, keep warm and stir, and purify to obtain the intermediate material; add carboxymethyl chitosan to dissolve in water, add the intermediate material, stannous chloride, mix evenly, feed inert gas, heat up, keep warm, and purify to obtain modified chitosan; the modified chitosan, diisopropylcarbodiimide, glucose and cinnamon oil are mixed evenly, and the absorbable medical suture thread with good tensile strength is prepared according to the method of melt spinning. The suture prepared by the invention has good tensile strength, is easy to knot, has high mechanical properties, and has good compatibility with biological tissues, and cells are easy to adhere and multiply on the suture prepared by the invention.
Owner:安徽省康宁医疗用品有限公司
Nano bone biomimetic material containing tussah silk fibroin, and preparation method thereof
InactiveCN102188753BGood biocompatibilityImprove biological activityProsthesisPorosityBone structure
The invention discloses a nano bone biomimetic material containing tussah silk fibroin, which is prepared from hydroxyapatite, tussah silk fibroin and chitosan, wherein the mass ratio of the hydroxyapatite to the tussah silk fibroin to the chitosan is 1:(0.1-0.5):(0.1-0.5). The porous nano bone biomimetic material containing tussah silk fibroin obtained by the invention has a big amount of intercommunicated micropores of the nano level, and has a higher porosity; the components containing the bone biomimetic material have good biological compatibility and structurally simulate the bone structure; and the hydroxyapatite / tussah silk fibroin nano compound particles are of the nano level and form strong binding force with the chitosan. The bone biomimetic material disclosed by the invention has good mechanical property, good formability and reasonable porosity, and can be used as an implanted degradable bone repair material.
Owner:ZHONGYUAN ENGINEERING COLLEGE
A kind of preparation method of absorbable medical suture thread
ActiveCN105088408BImprove mechanical propertiesHigh mechanical strengthSuture equipmentsMelt spinning methodsLactideGenipin
Owner:安徽省康宁医疗用品有限公司
Method for preparing flamazine/bacterial cellulose composite wound dressing
ActiveCN101905031BBroad spectrum antibacterialHigh antibacterial activityAbsorbent padsBandagesWound dressingMoisture absorption
The invention provides a method for preparing flamazine / bacterial cellulose composite wound dressing, which comprises the following steps of: performing pretreatment and purification treatment on a bacterial cellulose membrane to obtain purified bacterial cellulose; preparing flamazine suspension with the granularity of 50 to 5,000 nm under dark condition; reacting the bacterial cellulose membrane with the flamazine suspension to form a flamazine / bacterial cellulose composite membrane; and performing drying treatment to obtain a dry flamazine / bacterial cellulose composite membrane, or performing extruding dehydration to obtain a wet flamazine / bacterial cellulose composite membrane with different water content values to prepare the flamazine / bacterial cellulose composite wound dressing. The prepared flamazine / bacterial cellulose composite wound dressing has high mechanical performance, high antibacterial property, and high water and air permeability or good drainage and moisture absorption effects, can promote the drying, scabbing and healing of wound, and is used for preventing and treating the secondary wound infection of second-degree and third-degree burn or scald.
Owner:UNIV OF SCI & TECH BEIJING +1
A kind of nano cartilage repair material with oriented nanofiber mat as skeleton and preparation method thereof
InactiveCN104998302BHigh strengthImprove mechanical propertiesProsthesisPolymer scienceFreeze-drying
The invention relates to a nano cartilage repair material taking an aligned nanofiber mat as a skeleton and a preparation method of the nano cartilage repair material. The nano cartilage repair material is prepared by preparing the aligned nanofiber mat containing graphene for being used as the skeleton through an electrospinning technique, casting a mixed solution containing fibroin, hyaluronic acid, chondroitin sulfuric acid and hydroxyapatite particles, and preparing the material through a crosslinking technique and a freeze drying device. The preparation method specifically comprises the steps of preparing a mixed solution containing fibroin and hyaluronic acid of the grapheme for being used as a spinning solution, electrostatically spinning to obtain the aligned nanofiber mat for being used as the skeleton, casting the mixed solution containing the fibroin, the hyaluronic acid, the chondroitin sulfuric acid and the hydroxyapatite particles after being stabilized through glutaraldehyde steam crosslinking, then carrying out a cross-linking reaction at the temperature of minus 20 DEG C to minus 40 DEG C by using a cross-linking agent, and preparing through freeze drying at the temperature of minus 54 DEG C. The nano cartilage repair material taking the aligned nanofiber mat as the skeleton, prepared by the invention, simulates a natural bone in the aspect of ingredient and structure, has excellent mechanical property, reasonable poriness and good biocompatibility and biological activity, can be used as the repair or substitute material for cartilage tissues, and has wide application prospect.
Owner:ZHONGYUAN ENGINEERING COLLEGE
Copolymer of fibroin and poly D,L-lactic acid, preparation method and application thereof
Owner:NANJING FORESTRY UNIV
Method for preparing RGD-polypeptide grafted poly(maleidohexanediamine acid-D,L-lactic acid)/beta-TCP composite material
The invention relates to a method for preparing a RGD-polypeptide grafted poly(maleidohexanediamine acid-D,L-lactic acid) / beta-TCP composite material. According to the method, maleidohexanediamine acid and RGD-polypeptide are adopted to modify polylactic acid, then cell affinity of the polylactic acid can be improved, and the polylactic acid is beneficial to adhesive growth of cells; hexamethylendiamine has the main function of controlling accumulation of acidity in the degradation process, and sterile necrosis of implanted tissue can be prevented; maleidohexanediamine acid is firstly synthesized, a polylactic acid side chain is further introduced, then the reaction times of polylactic acid can be reduced, molecular weight reduction of the polylactic acid can be avoided, and the mechanicalproperties of the composite material can be ensured; calcium and phosphorous ions generated from degradation of beta-TCP as a biodegradable material with good biocompatibility are also essential substances for growth of bone tissue, nerve cells and the like.
Owner:WUHAN UNIV OF TECH
Copolymer of fibroin and poly L-lactic acid, solid phase polymerization preparation method and application thereof
The invention discloses a copolymer of fibroin and a poly L-lactic acid. The molecular weight of the copolymer having the structure is 5,000-200,000, and the mass ratio of the fibroin chain segment and the poly L-lactic acid chain segment is 1 / 99-99 / 1. The invention also discloses a solid phase polymerization preparation method thereof and the application thereof in biomedical materials. The invention adopts the method of direct polymerization, the copolymer of fibroin and the poly L-lactic acid is prepared through main body melt / solid phase polymerization, and solvent is not used in the synthesis technique; therefore, the invention has the advantages that the process is simple, the product cost is low, the production cycle is short, and no pollution is generated. Through the invention, copolymer of fibroin and poly L-lactic acid with different number average molecular weight can be prepared, with the molecular weight of 5,000-200,000. Copolymer of fibroin and poly L-lactic acid prepared through the invention can improve the hydrophilicity, the biocompatibility and the cellualar affinity of lactic acid material and control the degradation speed of the material.
Owner:NANJING FORESTRY UNIV
Poly alpha-alcohol acid ester/chitosan ultrafine fiber hybridization film material and its preparation
A poly alpha alcohol acid ester / chitosan superfine fiber hybridization material and the preparation process thereof are disclosed. It belongs to tissue repairing material technology. The film having thickness of 10 mu m-50 mu m is formed by poly alpha alcohol acid ester fiber, the diameter of which being 50nm-500nm, chitosan, the mass percent of which is 10-90%, polyvinyl alcohol or polyoxyethylene, the diameter thereof being 50nm-500nm. The preparation process is as follows: dissolving PLA or PLGA into N,N- dimethytoluamide to prepare poly alpha alcohol acid ester spinning solution with concentration being 20%-25%, dissolving chitosan to acetic acid aqueous solution, adding polyvinyl alcohol or polyoxyethylene to solution to prepare for chitosan spinning solution with concentration 4%-8%, injecting said spinning solutions separately to the multi-channel electrostatic spinning device, conduct simultaneously electrostatic spinning and film converging in separate channels to prepare for film, with the voltage being 5kV-30kV, liquid inventory being 0.1mL / h-0.5mL / h, receiving range being 5cm-25cm. The film has advantages of large water absorption, regulatable degrading rate and favorable cellular affinity.
Owner:TIANJIN UNIV
Multiplex composite bone tissue engineering bracket material capable of degrading gradiently and preparation method thereof
The invention discloses a multiplex composite engineering scaffold material capable of gradually decomposing bone tissue and a preparation method thereof. The composite scaffold material consists of calcium phosphate bone cement, biological compatible degradable synthetic high polymer and biological compatible degradable natural high polymer, has better mechanical property and gradient degradation characteristic, and can achieve the aim of regenerating and repairing bone tissue defect by implanting a bone growth factor to induce in-vivo stem cells to be differentiated into bone cells, therebyobviously improving initial strength and toughness of the scaffold material, and ensuring enough strength and toughness of the scaffold material during operating and implanting. After compounded withthe high polymer material, the scaffold has excellent flexibility, so that the scaffold can be subjected to certain machining, such as cutting and the like.
Owner:SOUTH CHINA UNIV OF TECH
Copolymer of fibroin and poly L-lactic acid, preparation method thereof through ring-opening polymerization and application thereof
The invention discloses a copolymer of fibroin and poly L-lactic acid, which comprises the following structure. The invention also discloses a preparation method for the copolymer through ring-opening polymerization and application of the copolymer in biomedical materials. The preparation method comprises the following steps of: preparing the copolymer of the fibroin and the poly L-lactic acid byperforming the ring-opening polymerization on L-lactide in a molten state and performing copolymerization with the fibroin; and adopting solid phase polymerization to perform post condensation polymerization so as to further improve the molecular weight of the copolymer, reduce the contents of a monomer and a low molecular weight polymer in the system, and prepare a copolymer with narrow molecular weight distribution. A solvent is not used in the polymerization process, so the process is simple and the product cost is low. The preparation method can prepare the copolymers of the fibroin and poly the L-lactic acid with different number-average molecular weights. The copolymer of the fibroin and poly the L-lactic acid prepared by the method can improve the hydrophilic property, the biocompatibility and the cellular affinity of a polylactic acid material, and control the degrading speed of the material.
Owner:NANJING FORESTRY UNIV
An absorbable medical suture with good mechanical properties
ActiveCN105079869BImprove mechanical propertiesLong degradation cycleSuture equipmentsLactidePolyethylene glycol
Owner:安徽省康宁医疗用品有限公司
Chitosan modified alginate hydrogel three-dimensional porous bracket and preparation method thereof
InactiveCN101773683BRich sourcesControllable physical and chemical propertiesProsthesisCross-linkPhosphate
Owner:TIANJIN UNIV
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