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Copolymer of fibroin and poly D,L-lactic acid, preparation method and application thereof

A silk protein and copolymer technology, applied in the field of silk protein and poly-D, can solve the problem of no research report

Inactive Publication Date: 2011-06-15
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no research report on this aspect at home and abroad

Method used

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  • Copolymer of fibroin and poly D,L-lactic acid, preparation method and application thereof
  • Copolymer of fibroin and poly D,L-lactic acid, preparation method and application thereof
  • Copolymer of fibroin and poly D,L-lactic acid, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] D, L-lactide, dehydrated silk protein powder (number average relative molecular mass 3000), SnCl 2 / p-toluenesulfonic acid catalyst system (SnCl 2 The molar content accounts for 50% of the whole catalyst system) into the polymerization tank. SnCl 2 The dosage is 0.5wt% of D, L-lactide, and the mass ratio of D, L-lactide to silk protein is 4:1. The pressure of the system was gradually reduced to 0 mmHg (manometer reading) and then sealed, the reaction temperature was 170° C., and the reaction time was 10 hours. After the polymerization, the obtained copolymer was dissolved in ethyl acetate, filtered and precipitated with ether, and the filtered precipitate was vacuum-dried at 65° C. for 16 hours to obtain a purified copolymer of silk protein and poly D, L-lactic acid. After purification, the copolymer is a yellow powder with a molecular weight of 12,000, a yield of 75%, and no melting point.

Embodiment 2

[0055] D, L-lactide, silk fibroin protein powder (the number average relative molecular mass is 3000), SnCl 2 / naphthalenesulfonic acid catalyst system (SnCl 2 The molar content accounts for 50% of the whole catalyst system) into the polymerization tank. SnCl 2 The dosage is 0.5wt% of D, L-lactide, and the mass ratio of D, L-lactide to silk protein is 10:1. The pressure of the system was gradually reduced to 10 mm Hg and then sealed, the reaction temperature was 170° C., and the reaction time was 10 hours. After the polymerization was complete, the resulting copolymer was dissolved in ethyl acetate, filtered and precipitated with diethyl ether. The filtered precipitate was vacuum-dried at 65° C. for 16 hours to obtain a purified polylactic acid and silk fibroin peptide chain copolymer. The purified copolymer is a yellow powder with a molecular weight of 16,300, a yield of 73%, and a melting point of 120°C.

Embodiment 3

[0057] Add D, L-lactide, silk fibroin protein powder (number-average relative molecular mass is 1000), stannous octoate / naphthalenesulfonic acid catalyst system (the molar content of stannous octoate accounts for 50% of the entire catalyst system) into the polymerization kettle middle. The dosage of stannous octoate is 0.5wt% of D, L-lactide, and the mass ratio of D, L-lactide to silk protein is 10:1. The pressure of the system was gradually reduced to 2 mm Hg and then sealed, the reaction temperature was 170° C., and the reaction time was 15 hours. After the polymerization was complete, the resulting copolymer was dissolved in ethyl acetate, filtered and precipitated with diethyl ether. The filtered precipitate was vacuum-dried at 65° C. for 10 hours to obtain a copolymer of purified silk protein and poly-D, L-lactic acid. The purified copolymer is a yellow powder with a molecular weight of 18,000, a yield of 76%, and a melting point of 130°C.

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Abstract

The invention discloses a copolymer of fibroin and a poly D,L-lactic acid. The molecular weight of the copolymer having the structure is 5,000 to 180,000, and the mass ratio of the fibroin chain segment and the poly L-lactic acid chain segment is 0.5 / 99.5-99 / 0.5. The invention also discloses a solid phase polymerization preparation method thereof, the application thereof in biomedical materials, nano material thereof and a preparation method of nano materials. Copolymer of fibroin and poly D,L-lactic acid is prepared by adopting melt ring opening polymerization, and solvent is not used in thesynthesis technique; therefore, the invention has the advantages that the process is simple, and the product cost is low. Through the invention, copolymer of fibroin and poly D,L-lactic acid with different number average molecular weight can be prepared. Copolymer of fibroin and poly D,L-lactic acid prepared by the invention can improve the hydrophilicity, the biocompatibility and the cellualar affinity of lactic acid material and control the degradation speed of the material.

Description

Technical field: [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a copolymer of silk protein and poly D, L-lactic acid, a preparation method and application thereof. Background technique: [0002] Polylactic acid (PLA) is a biodegradable and absorbable polymer material with good biocompatibility. It has the advantages of good biocompatibility, degradation products can participate in the metabolism of the human body, and low toxicity. It has been widely used in tissue engineering and other biomedical fields. However, polylactic acid also has performance defects, such as greater brittleness, lower mechanical strength, and difficulty in controlling the degradation cycle. In addition, PLA is a hydrophobic polymer with poor adhesion to cells. Pure polylactic acid as a tissue engineering material will cause some mild inflammatory reactions after being implanted into the organism. Therefore, in order to improve the mechanica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08H1/00C08G63/685C08J3/00C08L89/00
Inventor 高勤卫李明子寇琴周壮丽吴国成
Owner NANJING FORESTRY UNIV
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