Poly alpha-alcohol acid ester/chitosan ultrafine fiber hybridization film material and its preparation
A hydroxyester and microfiber technology, applied in medical science, prosthesis, etc., can solve problems such as no research reports or invention patents on hybrid microfiber membranes, and achieve adjustable degradation rate and tensile strength. Good, the effect of the preparation method is simple
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Embodiment 1
[0011] Take M η 50,000 d, l-PLA 2.2g, dissolved in 10mL DMF at room temperature, and added 1% triethylbenzene ammonium chloride to make spinning solution. Take M η 0.6g of chitosan with a concentration of 200,000, and 0.6g of PVA with a degree of polymerization of 1750±50 and a degree of alcoholysis of 98%, were dissolved in 10mL of 2% dilute acetic acid at room temperature under magnetic stirring, and then the two were mixed Another 20 mL spinning solution was formed. Inject the above two spinning solutions into two 50mL syringes with inner diameter 0.8mm flat needles respectively, fix the syringes on the double-channel micro-syringe pump, and place a grounded metal receiving screen vertically at a distance of 10cm from the needles. Connect the needle to a 10kV high-voltage DC power supply, set the solution flow rate to 0.1mL / h for electrospinning, and collect ultrafine fiber hybrid films with a diameter of 100nm to 300nm on the receiving screen after 72 hours, in which chi...
Embodiment 2
[0013] Take M η 50,000 d,l-PLA 2.2g was dissolved in 10mL DMF at room temperature to prepare a spinning solution. Take M η 0.6g of chitosan for 650,000, and take M η 0.6 g of 2.3 million PEO was dissolved in 20 mL of 2% dilute acetic acid at room temperature under magnetic stirring to obtain another spinning solution. Using the same dual-channel electrospinning device, inject the above two spinning solutions into two 50mL syringes with a flat needle with an inner diameter of 0.8mm, respectively, when the receiving distance is 15cm, the voltage is 15kV, and the solution flow rate is 0.1mL / h Electrospinning is carried out under the conditions, and after 72 hours, a superfine fiber hybrid film with a diameter of 100nm-500nm is collected on the receiving screen, wherein the content of chitosan is 1%-20%.
Embodiment 3
[0015] Take M η 50,000 PLGA75 / 252.2g, dissolved in 10mL DMF at room temperature, and added 1% triethylbenzene ammonium chloride to make spinning solution. Take M η 0.6g of chitosan with a concentration of 200,000, and 0.6g of PVA with a degree of polymerization of 1750±50 and a degree of alcoholysis of 98%, were dissolved in 10mL of 2% dilute acetic acid at room temperature under magnetic stirring, and then the two were mixed Another 20 mL spinning solution was formed. Inject the above two spinning solutions into two 50mL syringes with inner diameter 0.8mm flat needles respectively, fix the syringes on the double-channel micro-syringe pump, and place a grounded metal receiving screen vertically at a distance of 10cm from the needles. Connect the needle to a 10kV high-voltage DC power supply, set the solution flow rate to 0.1mL / h for electrospinning, and collect ultrafine fiber hybrid films with a diameter of 100nm to 300nm on the receiving screen after 72 hours, in which chi...
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