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An absorbable medical suture with good mechanical properties

A technology of mechanical properties and sutures, which is applied in the field of medical sutures, can solve the problems of inability to adhere and reproduce cells, poor mechanical properties of chitosan, and accelerate wound healing, etc., to increase hydrophilicity and cytocompatibility, Increased anti-inflammatory, antibacterial and anti-inflammatory properties

Active Publication Date: 2017-08-15
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Inflammation, and has the advantages of anti-inflammatory, promoting wound healing, and smooth wound after healing, but chitosan has poor mechanical properties, poor solubility, and is easy to degrade
[0004] Polylactic acid (PLA) sutures are synthetic polymer sutures. The degradation rate of PLA fibers is slow and the mechanical properties are strong. However, PLA is hydrophobic, and cells cannot adhere and reproduce well on the fibers. The degradation cycle Longer, and the degradation product lactic acid can easily cause inflammation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] An absorbable medical suture with good mechanical properties, its raw materials include by weight: 100 parts of modified polylactic acid, 40 parts of polyglycolide, 4 parts of sorbitol, 5 parts of methacrylic acid, and 5 parts of cassia oil;

[0028] Among them, the preparation method of modified polylactic acid is: in an ice bath, add chitosan to perchloric acid and mix well, add sorbyl chloride dropwise, stir at a speed of 400r / min for 2h, cool down to -12°C, and keep warm for 10h , added dropwise to acetone, filtered to obtain a filter cake, dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to perchloric acid was 1:50, and the weight ratio of chitosan to sorbyl chloride 1.7:5; use ammonia water to adjust the pH of solution A to 8, filter, add ethanol, Soxhlet extraction for 20 hours, and vacuum dry to obtain modified chitosan; take polyethylene glycol, feed nitrogen, and heat up to 70°C. Keep warm until the polyethylene gl...

Embodiment 2

[0030] An absorbable medical suture with good mechanical properties, its raw materials include by weight: 120 parts of modified polylactic acid, 20 parts of polyglycolide, 6 parts of sorbitol, 3 parts of methacrylic acid, and 6 parts of cassia oil;

[0031] Among them, the preparation method of modified polylactic acid is: in an ice bath, add chitosan to perchloric acid and mix well, add sorbyl chloride dropwise, stir at a speed of 200r / min for 3h, cool down to -16°C, and keep warm for 20h , added dropwise to acetone, filtered to obtain a filter cake, dissolved in water to obtain solution A, wherein the weight-to-volume ratio (g / ml) of chitosan to perchloric acid was 1:30, and the weight ratio of chitosan to sorbyl chloride 1.7:7; use ammonia water to adjust the pH of solution A to 6, filter, add ethanol, Soxhlet extraction for 30 hours, and vacuum dry to obtain modified chitosan; take polyethylene glycol, feed nitrogen, and heat up to 60°C. Keep warm until the polyethylene gl...

Embodiment 3

[0033] An absorbable medical suture with good mechanical properties, its raw materials include by weight: 115 parts of modified polylactic acid, 25 parts of polyglycolide, 5.5 parts of sorbitol, 3.5 parts of methacrylic acid, and 5.8 parts of cassia oil;

[0034] Among them, the preparation method of modified polylactic acid is: in an ice bath, add chitosan to perchloric acid and mix well, add sorbyl chloride dropwise, stir at a speed of 250r / min for 2.8h, cool to -15°C, and keep warm. 17h, add dropwise to acetone, filter to obtain filter cake, add water to dissolve to obtain solution A, wherein, the weight volume ratio (g / ml) of chitosan and perchloric acid is 1:35, the weight of chitosan and sorbic acid chloride The ratio is 1.7:6.5; use ammonia water to adjust the pH of solution A to 6.5, filter, add ethanol, extract for 27 hours by Soxhlet, and dry in vacuum to obtain modified chitosan; take polyethylene glycol, inject nitrogen, and heat up to 62°C , keep warm until the po...

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PUM

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Abstract

The invention discloses an absorbable medical suture line with good mechanical performance. The absorbable medical suture line comprises, by weight, 100-120 parts of modified polylactic acid, 20-40 parts of polyglycollide, 4-6 parts of sorbitol, 3-5 parts of methyl methacrylate and 5-6 parts of cassia oil. The preparation method of the modified polylactic acid includes: in ice-bath, adding chitosan into perchloric acid, well mixing, dripping sorbic acid chloride, stirring, cooling, preserving heat and purifying to obtain modified chitosan; taking polyethylene glycol, feeding inert gas, heating, preserving heat until the polyethylene glycol melt, adding stannous chloride and lactide, well mixing, heating, preserving heat and stirring, and purifying to obtain intermediate material; dissolving the modified chitosan in mixed solvent, adding triethylamine, well mixing, heating, refluxing, adding the intermediate material, well mixing, continuing refluxing, purifying and drying to obtain the modified polylactic acid.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to an absorbable medical suture with good mechanical properties. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Inflammation, and has the advantages of anti-inflammatory, promoting wound healing, smooth wound after healing, etc., but chitosan has poor mechanical properties, poor solubility, and is easy to degrade. [0004] Polylactic acid (PLA) sutures are synthetic polymer sutures. The degradation rate of PLA fibers is s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/12A61L17/06
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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