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Multiplex composite bone tissue engineering bracket material capable of degrading gradiently and preparation method thereof

A technology for bone tissue engineering and scaffolding materials, applied in the field of biomedical engineering, can solve problems such as low strength, material collapse, and decreased cell affinity, and achieve the effect of good matching and improving strength and toughness.

Inactive Publication Date: 2012-09-26
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the course of many years of research and application, the problems of brittleness and low strength of calcium phosphate materials have not been well resolved, which limits its wide application.
However, since the added polymer material degrades faster than calcium phosphate bone cement, once the reinforcement randomly mixed with bone cement degrades, the strength of the scaffold will decrease significantly, which may make the material unable to bear the original load and collapse.
On the other hand, these enhancers have no effect on improving the biocompatibility and cell affinity of the scaffold, and some (such as PLGA) can even reduce the biocompatibility and cell affinity of the scaffold.
[0006] Studies on self-curing calcium phosphate tissue engineering scaffolds generally do not consider the regulation of the degradation rate of scaffolds

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1, polylactic acid / polyglycolic acid copolymer (PLGA) is dissolved in methylene chloride, is made into the solution of 10% mass percent concentration, stirs with magnetic stirrer 6 hours, obtains polylactic acid / polyglycolic acid copolymer solution, Put in a container for later use.

[0031] 2. Select a calcium phosphate bone cement porous scaffold with a total porosity of about 80% and a pore size of 200-400 μm, and put the calcium phosphate bone cement porous scaffold into the In a vacuum drying oven, vacuum dry at 50°C for 6 hours, take it out, soak it in the polylactic acid / polyglycolic acid copolymer (PLGA) solution prepared in step 1, put it into a vacuum desiccator, and vacuum it for 2 hours, and the polylactic acid / polyglycolic acid copolymer (PLGA) solution The polyglycolic acid copolymer (PLGA) solution was perfused into the pores of the calcium phosphate bone cement porous scaffold under the action of pressure and capillary force.

[0032] 3. Take out the ca...

Embodiment 2

[0037] 1. Dissolve polylactic acid (PLA) in 1,4-dioxane, prepare a polylactic acid solution with a concentration of 5% by mass, heat to 40°C, and stir for 12 hours until the polylactic acid is fully dissolved to obtain polylactic acid solution, ready to use.

[0038] 2. Select a calcium phosphate bone cement porous scaffold with a total porosity of about 95% and a pore size of 100-300 μm, and put the porous scaffold into In an ordinary electric drying oven, dry at 100°C for 1 hour, take it out, soak it in the polylactic acid solution prepared in step 1, put it in a vacuum desiccator, and vacuum it for 4 hours. The polylactic acid solution is perfused under pressure and capillary force. Calcium phosphate cement in the pores of porous scaffolds.

[0039] 3. Take out the scaffold material filled with PLA in the above-mentioned pores, dry the surface with filter paper, put it in a -40°C refrigerator for 6 hours, and then freeze-dry it at -40°C for 36 hours to obtain a composite c...

Embodiment 3

[0044] 1, polycaprolactone (PCL) / starch blend is dissolved in dimethyl sulfoxide, is mixed with the solution of 20% mass percentage concentration, is heated to 80 ℃, stands for 48 hours, waits for polycaprolactone ( PCL) / starch blend is fully dissolved to obtain polycaprolactone (PCL) / starch blend solution, which is ready for use.

[0045] 2. Select β-tricalcium phosphate (β-TCP) + sodium pyrophosphate (Na 4 P 2 o 7 ) system calcium phosphate bone cement porous scaffold, put the above porous scaffold into a vacuum drying oven, vacuum dry at 60°C for 4 hours, take it out, soak it into the polycaprolactone (PCL) / starch blend solution prepared in step 1 Put it in a vacuum desiccator and vacuumize for 3 hours, and the polycaprolactone (PCL) / starch solution is poured into the pores of the calcium phosphate bone cement porous scaffold under the action of pressure and capillary force.

[0046] 3. Take out the scaffold material filled with the polycaprolactone (PCL) / starch blend in...

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Abstract

The invention discloses a multiplex composite engineering scaffold material capable of gradually decomposing bone tissue and a preparation method thereof. The composite scaffold material consists of calcium phosphate bone cement, biological compatible degradable synthetic high polymer and biological compatible degradable natural high polymer, has better mechanical property and gradient degradation characteristic, and can achieve the aim of regenerating and repairing bone tissue defect by implanting a bone growth factor to induce in-vivo stem cells to be differentiated into bone cells, therebyobviously improving initial strength and toughness of the scaffold material, and ensuring enough strength and toughness of the scaffold material during operating and implanting. After compounded withthe high polymer material, the scaffold has excellent flexibility, so that the scaffold can be subjected to certain machining, such as cutting and the like.

Description

technical field [0001] The invention belongs to the tissue engineering material technology in the field of biomedical engineering, and in particular relates to a multiple composite gradient degradable bone tissue engineering scaffold material and a preparation method thereof. Background technique [0002] There are many cases of bone defects caused by industrial accidents, traffic accidents, orthopedic inflammation, bone tumors, and age-related orthopedic diseases, which have seriously affected people's health and quality of life. The current clinical treatment methods for bone defects mainly include: autologous bone graft, allogeneic bone graft and artificial material repair. Although autologous bone is an ideal material for bone grafting, the sources of bone donors are limited. The second operation will bring pain to the patient and cause new damage to the donor. It is rich, can be stored in advance, and is convenient to use, but it has immune rejection, and the omissions...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/24A61L27/22A61L27/20A61L27/14A61L27/12A61L27/56A61L27/50
Inventor 叶建东何福坡王迎军漆小鹏陈晓峰吴刚
Owner SOUTH CHINA UNIV OF TECH
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