The invention discloses a novel environmentally-friendly high-efficiency methanol gasoline composite additive formula. Components of the formula contain no substances, such as sulphur, phosphor, benzene, heavy metal and the like, that are harmful to the environment and human body, and multiple problems such as low calorific value, layering, cold-start, thermal resistance, corrosion and the like, that appear during the using process of methanol gasoline are solved. The formula contains, by volume, 10-30% of alkane, 5-15% of an ether compound, 5-30% of an alcohol component, 5-15% of an ester compound, 5% of a high energy agent, 5-15% of a plasticizer, 5-15% of a cleaning agent, 0.001% of a nano-catalyst and 1-15% of an anti-oxidant and anti-corrosive additive. The methanol gasoline blended according to the formula has high calorific value, is safe to use and is economic and environmentally friendly.