The invention discloses a leakage detection device of large soft transfusion package bags or soft bottles, and relates to the technical field of pharmaceutical packaging machinery. The leakage detection device is composed of a rack (4), a programming logic controller (3), a vertical beam (19), a horizontal beam (22), an extrusion fixed plate (17), a fixture (23), a recycling bin (2), a motor (32) with a brake and a deceleration component, and a leakage detection component. The device has the characteristics of high detection precision, low working intensity, safety and reliability and the like, is suitable for the leakage detection of non-PVC (poly vinyl chloride) film large soft transfusion package bags in various specifications or PP large soft transfusion bottles in various specifications, and can be suitable for the leakage detection of large soft transfusion package bags or soft bottles in various specifications, which are made of other materials.