The invention belongs to the technical field of chemical preparations, and particularly relates to a high-efficiency defoaming agent and a preparation method thereof, which solves the problems in the prior art that the defoaming efficiency is low, the requirement on preparation equipment is strict, and the preparation process has safety potential hazard. The high-efficiency defoaming agent is prepared from the following raw materials: organosiloxane, dimethicone, hexenyl distearic amide, glycerol monostearate, molybdenum disulfide, montmorillonite powder, metal oxide, charcoal powder, inorganic salt, surfactant and polyvinylether. The preparation method comprises the following steps: S1, mixing dimethicone and polyvinylether, and adding organosiloxane; S2, slowing down, adding the hexenyl distearic amide, glycerol monostearate and surfactant, speeding up, adding the montmorillonite powder, molybdenum disulfide, charcoal powder and inorganic salt, then adding a 4A molecular sieve and metal oxide, thus obtaining the high-efficiency defoaming agent. The defoaming agent disclosed by the invention is stable in performance, good in defoaming effect, small in consumption amount, simple in preparation method, low in equipment requirement and safe in production process.