42results about How to "Effective killing effect" patented technology

The invention discloses an EGFRvIII antibody, a conjugate thereof, a preparation method and application. The antibody comprises complementarity determining regions (CDRs) of the EGFRvIII antibody: oneor more of a heavy chain CDR1, a heavy chain CDR2, and a heavy chain CDR3, and / or one or more of a light chain CDR1, a light chain CDR2 and a light chain CDR3, the amino acid sequences of antibody are described herein. The EGFRvIII antibody has high affinity with an EGFRvIII protein, can enter a cell after being coupled with a small molecule toxin such as MMAE, and performs cytotoxic killing effect on EGFRvIII positive cells. Therefore, the EGFRvIII antibody can be applied to preparation of medicines for treating tumors and the like.

The invention aims to provide a high antibacterial ferritic stainless steel material and a preparation method thereof. The high antibacterial ferritic stainless steel material has the function of effectively resisting high concentration bacteria (more than (1-2)*10<6>CFU / mL) under conditions of solid solution and aging heat treatment, and significantly reduces the risk of corrosion of bacterial microorganisms caused by the use of ferritic stainless steel. The stainless steel comprises the chemical compositions of 17.5-19.5% of Cr, 1.9-2.5% of Mo, 2.0-4.5% of Cu, 1.0-2.5% of Ga, less than or equal to 0.035% of N, less than or equal to 0.025% of C, less than or equal to 1.0% of Si, less than or equal to 1.0% of Mn, less than or equal to 0.04% of P, less than or equal to 0.03% of S and the balance Fe. The high antibacterial ferritic stainless steel can be widely used in food and chemical industries and civil liquid transportation pipes or storage containers which contain the bacteria.

The invention discloses a TPBG antibody, its preparation method, its conjugate and application. The TPBG antibody includes one or more of the heavy chain variable region heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of the TPBG antibody, and / or, the light chain variable region light chain CDR1, light chain CDR1 of the TPBG antibody One or more of CDR2 and light chain CDR3, the amino acid sequences of which are respectively described in the present invention. The TPBG antibody is a humanized antibody with high affinity, and the conjugate prepared after coupling with the small-molecule drug toxin MMAF can have a cytotoxic killing effect on TPBG-positive cells, so it is used in the preparation of drugs for treating tumors and the like middle.

The invention aims to provide an ultrahigh-antibacterial-performance austenitic stainless steel material applied to a medical implantable stent and a preparation method thereof. The ultrahigh-antibacterial-performance austenitic stainless steel material has an effective function of resisting to high-concentration bacteria (>(8-9)*10<6> CFU / mL) in the heat treatment state of solution treatment andaging, and the risk of corrosion of bacteria microorganisms caused by the use of austenitic stainless steel can be remarkably reduced. The stainless steel comprises the following chemical components of, by weight, 16.0%-17.5% of Cr, 10.0%-14.0% of Ni, 2.0%-3.0% of Mo, 2.5%-4.5% of Cu, 1.0%-2.5% of Ga, 0.1%-0.15% of N, less than or equal to 0.03% of C, less than or equal to 0.75% of Si, less than or equal to 2.0% of Mn, less than or equal to 0.045% of P, less than or equal to 0.03% of S and the balance Fe. The ultrahigh-antibacterial-performance austenitic stainless steel is widely applied to material of the medical implantable stent, and specifically applied to medical implantable stent products such as a cardiovascular stent, a urethra stent, an intestinal stent and a bile duct stent.

The invention relates to the microbial fertilizer field, and particularly relates to a core bio-control bacteria and an organic fertilizer containing the core bio-control bacteria. Effective components of the core bio-control bacteria are harzianum and hygrospinocus var. beigingenis. The organic fertilizer comprises following components by weight: 3-7 parts of the core bio-control bacteria, 3-7 parts of tea saponin, 75-89 parts of organic materials and 5-11 parts of plant nutrients. The invention also provides a method of preparing the organic fertilizer containing the core bio-control bacteria. According to the organic fertilizer containing the core bio-control bacteria, the core bio-control bacteria can effectively prevent or relieve disease harm and pest harm which are caused by continuous cropping, and has a function of microbial remediation of soil pollution; the tea saponin has functions of repelling injurious insects and biotin; and the organic materials in the fertilizer can promote formation of a soil granular structure.

The invention aims to provide an ultrahigh-antibacterial-performance titanium alloy applied to a medical implant and a manufacturing method of the ultrahigh-antibacterial-performance titanium alloy. The ultrahigh-antibacterial-performance titanium alloy and the manufacturing method of the ultrahigh-antibacterial-performance titanium alloy aim to achieve the effects that under the solid solution and aging heat treatment states of the titanium alloy, a function of effectively resisting high-concentration bacteria (larger than (8-9)*10<6> CFU / mL) is achieved, and the corrosion risk of bacteria microorganisms caused by the use of the titanium alloy is remarkably reduced. The titanium alloy comprises the following chemical components of, by weight, 5.5-6.5% of Al, 6.5-7.5% of Nb, 1.0-3.0% of Gaand the balance Ti. According to the heat treatment mode after material optimization, the temperature of the solid solution treatment is 950-1000 DEG C, heat preservation is carried out for 1.0-2.0 hours, and the temperature is reduced to the room temperature through water cooling. The ultrahigh-antibacterial-performance titanium alloy is widely applied to the multiple kinds of titanium alloy medical implants which are used in the medical clinic fields of a department of stomatology and a department of orthopedics, and the implants particularly refer to the dental implants, bone screws, bonefracture plates, (knee, ankle, shoulder and hip) joints and other common medical surgical implants.