The invention relates to a mounting and fixing device for a single layer of glass of a DF4 locomotive side wall, and belongs to the technical field of machine manufacturing and mounting. The mounting and fixing device comprises an outer side pressing frame and an inner side pressing frame, and the outer side pressing frame and the inner side pressing frame are two symmetrical arc-shaped structures. The outer side pressing frame is provided with a convex pillar, the inner side pressing frame is provided with a concave groove, and the concave groove and the convex pillar are connected in a buckled mode. According to the mounting and fixing device, the inner side pressing frame and the outer side pressing frame which are made of aluminum alloy are used for fixing the locomotive side wall glass, corrosion damage to the pressing frames by the external environment can be effectively prevented, the service life of the pressing frames is prolonged, and maintenance cost and environmental pollution are lowered. The inner side pressing frame and the outer side pressing frame are provided with the buckled structures, so that the firmness is enhanced, dismounting is easy, maintenance is convenient, recycling can be achieved, the glass can be mounted more firmly, and shock resistance is good. The mounting and fixing device for the single layer of glass of the DF4 locomotive side wall is economical and practical, easy to operate, capable of saving energy, environmentally friendly, and high in firmness and shock resistance.