39 results about "Tangeretin" patented technology

The invention discloses a preparation method of pericarpium citri reticulatae absolute oil. The pericarpium citri reticulatae absolute oil is obtained through the steps of pericarpium citri reticulatae crushing, pericarpium citri reticulatae fermenting, pericarpium citri reticulatae extracting, extracting and filtering, concentrating, alcohol precipitating and concentrating. According to the obtain pericarpium citri reticulatae absolute oil, the content of flavonoids such as hesperidin, nobiletin and tangeretin and the content of volatile oil such as limonene are high, therefore, the unique aroma of pericarpium citri reticulatae is effectively kept, and the natural flavor is clearer when the pericarpium citri reticulatae absolute oil is applied to the cigarettes; in addition, the application range of the absolute oil can be wider, the state and solubility problems of a pericarpium citri reticulatae extract are solved, and the absolute oil can be better applied to the cigarettes; the preparation process is simple, the operability is high, the whole production process is efficient, and the method is suitable for industrialized implementation; on the other hand, when the pericarpium citri reticulatae absolute oil prepared through the method is applied to the cigarettes, the mouthfeel and the aftertaste of cigarette smoking can be improved, the special natural flavor can be given to the cigarettes, and the smoke quality can be promoted.

The invention provides a method of separating and purifying polymethoxyflavone compounds from tangerine fruits. By taking pericarp of the tangerine fruits as a raw material, the method finally obtains three high purity polymethoxyflavone compounds: nobiletin, tangeretin and 5-nor-nobiletin by adopting ultrasonic-assisted extraction and desaccharification and segmentation by a solid-phase extraction column (formula as shown in the description) by means of a high-speed countercurrent chromatography (HSCCC) purification and separation technology. The method without high temperature and high pressure and inert gas protection is simple to operate, short in production period, small in dosage of samples, stable and easy for condition control, short in production period and wide in adaptability; the purified product is high in recovery rate and high in purity, and the purities of the three compounds are 98% above; the used solvent can be recycled and repeatedly used, the cost is relatively low, and the purification process is precisely determined and quantified and high in accuracy; and the substance resolution ratio and reappearance degree of HSCCC can be improved. The method is suitable for industrial production and scientific research.

The invention provides a method for extracting nobiletin and tangeretin from citrus. The method for extracting the nobiletin and the tangeretin from the citrus includes following steps: step A, using a mixed solution of first organic solvent and water as an extracting agent, controlling pH (potential of hydrogen) value of the solution at 8-9 to perform reflux extraction on extracted material once or more than once, mixing and concentrating extraction solutions to obtain a tangeritin concentrated solution; step B, using second organic solvent for extracting the tangeritin concentrated solution, and separating an organic phase and a water phase out; step C, removing the extracting agent out of the organic phase, and then sequentially using first eluent and second eluent for elution in macroporous adsorption resin, and respectively collecting the nobiletin and the tangeretin. The method for extracting the nobiletin and the tangeretin from the citrus solves the problem that extraction efficiency is low caused by single extracted components and repeated elution in the prior art.

The invention provides application of tangeretin in preparation of a medicine for treating functional pituitary adenoma. According to the technical scheme, the tangeretin in the invention is capable of effectively inhibiting cell proliferation of prolactinomas MMQ on a cellular level and presents obvious time dependence and dose dependence. Meanwhile, the tangeretin can achieve effects of obviously inducing apoptosis of MMQ cells, effectively inhibiting tumor growth of tumor-bearing mice on an animal model level and prolonging the life cycle of the tumor-bearing mice. Therefore, due to use ofthe tangeretin, a novel solution is provided for treatment of the prolactinomas.

The invention discloses a method for separating tangeretin and nobiletin from citrus flavonoid extract, comprising the main steps: crushing immature bitter orange or orange peel, adding a first organic solvent, and refluxing for extracting to obtain first extract liquid; adding the first organic solvent again, refluxing for extracting to obtain second extract liquid, and combining the second extract liquid with the first extract liquid; recycling the extract liquid to obtain crude extract; adding clear water, mixing to obtain a mixed solution, and adding a second organic solvent for extracting to obtain a water layer and an organic layer; recycling the organic layer to obtain extract; adding a third organic solvent and activated carbon; extracting a mixture, subjecting extraction liquid to cooling and filtering to obtain filtrate and activated carbon residue, vacuum concentrating the filtrate to obtain secondary extract; adding ethyl alcohol to dissolve the secondary extract, and separating and refining to obtain tangeretin; dissolving the activated carbon residue with ethyl alcohol, and acquiring secondary extract by cooling, filtering and ethyl alcohol recycling; adding ethyl alcohol for reflux dissolving, and separating and refining to obtain nobiletin. The problem that it is difficult for the prior art to acquire high content of polymethoxyflavonoids and the component is single is solved.

The invention relates to compositions and methods for treating hypercholesterolemia, including methods for increasing HDL cholesterol levels, using a composition comprising an extract from the Ortanique peel. The invention also relates to compositions and methods for treating hypercholesterolemia, including methods for increasing HDL cholesterol levels, using a composition comprising substantially similar amounts of tetramethylscutellarein and nobiletin by weight and / or a composition comprising substantially similar amounts of tetramethylscutellarein, nobiletin, and tangeretin by weight.

The invention discloses a method for separating tangeretin and nobiletin from citrus flavonoid extract, comprising the main steps: crushing immature bitter orange or orange peel, adding a first organic solvent, and refluxing for extracting to obtain first extract liquid; adding the first organic solvent again, refluxing for extracting to obtain second extract liquid, and combining the second extract liquid with the first extract liquid; recycling the extract liquid to obtain crude extract; adding clear water, mixing to obtain a mixed solution, and adding a second organic solvent for extracting to obtain a water layer and an organic layer; recycling the organic layer to obtain extract; adding a third organic solvent and activated carbon; extracting a mixture, subjecting extraction liquid to cooling and filtering to obtain filtrate and activated carbon residue, vacuum concentrating the filtrate to obtain secondary extract; adding ethyl alcohol to dissolve the secondary extract, and separating and refining to obtain tangeretin; dissolving the activated carbon residue with ethyl alcohol, and acquiring secondary extract by cooling, filtering and ethyl alcohol recycling; adding ethyl alcohol for reflux dissolving, and separating and refining to obtain nobiletin. The problem that it is difficult for the prior art to acquire high content of polymethoxyflavonoids and the component is single is solved.

Disclosed in certain embodiments is a pharmaceutical formulation, such as a tablet, gel capsule, solution, liquid, suspension or emulsion, comprising a pharmaceutical ingredient comprising an active agent combination comprising flavonoids and tocotrienols in a ratio of about 75:25 to about 95:5 and at least one pharmaceutical acceptable excipient. The flavonoids may comprise naringenin, hesperetin, nobiletin or tangeretin. The tocotrienols may comprise alpha-tocotrienol, gamma-tocotrienol or delta-tocotrienol. The formulations may be used to lower total cholesterol, triacylglycerols, LDL cholesterol and Apo B.

The present disclosure provides compositions containing: 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one ("sinensetin"); 3,5,6,7,8,3',4'-heptamethoxyflavone ("heptamethoxyflavone" or "HMF"); 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy- chromen-4-one ("nobiletin"); 5,6,7,4'-tetramethoxyflavone ("tetra-O-methylscutellarein" or "TMS"); 3,5,6,7,3',4'-hexamethoxyflavone ("hexamethoxyquercetogetin" or "HMQ"); 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one ("tangeretin"); or any combinations thereof. The disclosure also provides uses of such compositions as mouthfeel enhancers or bitterness maskers of flavored articles, such as beverages.

The present invention provides a composition containing tangeretin as an active ingredient for external application to the skin. The present invention also provides a composition containing tangeretin and EGCG for external application to the skin. The present invention also provides a composition for external application to the skin, comprising, as an active ingredient, mandarin peel extracts containing tangeretin. The present invention also provides a composition for external application to the skin comprising mandarin peel extracts containing tangeretin and further comprising green tea extracts containing Epigallocatechin gallate (EGCG). The composition of the present invention has excellent antioxidative effects and therefore can be applied as a cosmetic composition, a pharmaceutical composition or a health food composition. Further, the composition of the present invention may have superior effects of preventing skin erythema, improving skin tone and preventing skin aging.

The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is tangeretin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.