The invention discloses antibacterial, disease-resisting and anti-hypoxia growth-promoting feed of mandarin fish. The antibacterial, disease-resisting and anti-hypoxia growth-promoting feed is prepared from the following raw materials including fishmeal, alpha-starch, tenebrio molitor powder, mung bean flour, rice bran powder, fermented soybean meal, carotene, vitamin E, lecithin, brown sugar, soybean phospholipid, mixed oil, citric acid, streptococcus lactis, a traditional Chinese medicine complex agent, phytase, dihydropyridine, glucocyamine, phenylglycin, cysteamine hydrochloride, L-carnitine, soybean isoflavone, chitosan, malto oligosaccharides, probiotics, astaxanthin, lysozyme, nano-collagen, an emulsifying agent, novasil and flavomycin. With the adoption of the feed of the mandarin fish, disclosed by the invention, the antibacterial, disease-resisting and anti-hypoxia capability of the mandarin fish can be effectively improved and the growth of the mandarin fish is promoted.