The invention relates to a
losartan potassium gastric floating
capsule, which comprises
losartan potassium, PEG6000 (polyethyleneglycol),
stearic acid, octodecyl
alcohol, pre-gelatinized
starch and mannite, wherein the
losartan potassium is a powdery substance which is sieved with a 100-mesh
sieve. A preparation method of the
capsule comprises the following steps of: S1, mixing the PEG6000, the
stearic acid and the octodecyl
alcohol according to a certain proportion, heating to 64-66 DEG C, and
smelting into a liquid; S2, heating the liquid mixture to 69-72 DEG C, and preserving heat for 9-11 minutes; S3, adding a proportional amount of
losartan potassium into the mixture obtained in the step S2, keeping the temperature at 69-72 DEG C, and stirring uniformly; S4, adding a proportional amount of the pre-gelatinized
starch and the mannite, and stirring uniformly; and S5, after the uniformity is qualified,
filling in a hot state, covering a
capsule cap, and cooling to the
room temperature. The
losartan potassium gastric floating capsule has the advantages that the medicament releasing time is long, the
medicine taking times of a patient are reduced, the
treatment compliance of the patient is enhanced, and the quality in a storage life is stable.