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Preparation method for compound losartan potassium-hydrochlorothiazide pharmaceutical composition

A losartan potassium hydrochlorothiazide tablet and a technology for hydrochlorothiazide are applied in the field of preparation of losartan potassium hydrochlorothiazide tablets, and can solve the problems of affecting the dissolution and release rate of amlodipine, the effect is not very obvious, the volume ratio of auxiliary materials is increased, and the like, achieving The difference in loading is not obvious, the fluidity is good, and the effect of improving stability

Active Publication Date: 2015-03-11
TIANJIN HANKANG PHARMA BIOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the existing technology shows that the interaction between losartan potassium and amlodipine affects the dissolution release rate of amlodipine. The commonly used method is to increase the volume of excipients Ratio, increasing tablet weight, but the effect is still not very obvious

Method used

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  • Preparation method for compound losartan potassium-hydrochlorothiazide pharmaceutical composition
  • Preparation method for compound losartan potassium-hydrochlorothiazide pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] particle 1

[0034] Losartan Potassium 50g

[0035] Starch 150g

[0036] 10% starch slurry appropriate amount

[0037] particle 2

[0038] Hydrochlorothiazide 12.5g

[0039] Croscarmellose Sodium 10g

[0040] Lactose 150g

[0041] 5% povidone K30 solution appropriate amount

[0042] Magnesium Stearate 2g

[0043] Makes 1000 pieces

[0044] The preparation steps are as follows:

[0045] 1) Sieve the prescription amount of losartan potassium, mix it evenly with starch, use 10% starch slurry to make a soft material with suitable hardness, use a 20-mesh sieve to granulate, and dry at 60°C to make the water content less than 5 %,spare;

[0046] 2) Pulverize the prescription amount of hydrochlorothiazide to a qualified particle size, and set aside;

[0047] 3) Mix the prescribed amount of hydrochlorothiazide, croscarmellose sodium, and lactose evenly, use 5% povidone K30 solution to prepare a soft material with suitable hardness, use a 20-mesh sieve to granulate, a...

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Abstract

The invention relates to a preparation method for a losartan potassium-hydrochlorothiazide tablet. The losartan potassium-hydrochlorothiazide tablet is characterized in that: after losartan potassium and starch are mixed, 10% of starch slurry is used to prepare particles with a suitable hardness; hydrochlorothiazide, cross linked sodium carboxymethyl cellulose and lactose are mixed, and particles with a proper hardness are prepared from an obtained mixture by using 5% of a polyvinylpyrrolidone K30 solution; the two kinds of particles and magnesium stearate are uniformly mixed and then are subjected to tabletting. According to the invention, a low dissolution rate caused by interaction among drugs in primary granulation is avoided, and an in vitro dissolution rate can be improved greatly, thereby enhancing bioavailability.

Description

technical field [0001] The invention relates to a preparation method of losartan potassium hydrochlorothiazide tablets. Background technique [0002] Hypertension is the most common cardiovascular disease in the world, and its prevalence rate is as high as 10%-20%. It can lead to heart, cerebrovascular and kidney lesions, and is one of the main diseases that endanger human health. During the more than 10 years from 1979 to 1991, the prevalence of hypertension in my country increased by 25%. According to the forecast of the World Health Organization, in 2020, non-infectious diseases will account for 79% of the causes of death in my country, and cardiovascular diseases will rank first. It has been reported that antihypertensive treatment will definitely reduce cardiovascular death and disability, and has a significant effect on preventing stroke, coronary heart disease, heart failure, kidney disease progression, developing into more severe hypertension, and reducing overall m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/549A61K31/4178A61K9/20A61P9/12
Inventor 黄欣
Owner TIANJIN HANKANG PHARMA BIOTECH
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