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Losartan potassium-containing medicine composition and preparation method thereof

A kind of technology of losartan potassium and adhesive, which is applied to the stable losartan potassium preparation and the field of preparation thereof, and achieves the effects of simple and practical process, improved stability, and suitability for large-scale industrial production

Inactive Publication Date: 2012-02-01
北京万全阳光医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no research on the ratio of losartan potassium to magnesium stearate and the dosage of starch

Method used

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  • Losartan potassium-containing medicine composition and preparation method thereof
  • Losartan potassium-containing medicine composition and preparation method thereof
  • Losartan potassium-containing medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031]

[0032] Tablet preparation process: (a) pass the main ingredient and magnesium stearate through an 80-mesh sieve, weigh according to the proportion, and mix uniformly in equal amounts; (b) starch, microcrystalline cellulose, low-substituted hydroxypropyl Base cellulose and lactose pass through a 80-mesh sieve, weigh according to the proportion, mix evenly, prepare 10% starch slurry as a binder, wet granulate, granulate with a 16-mesh sieve, dry, and granulate with a 24-mesh. (a) and (b) Two parts are added in equal amounts, mixed evenly, compressed into tablets, and coated.

Embodiment 2

[0034]

[0035] Tablet preparation process: (a) pass the main ingredient and magnesium stearate through an 80-mesh sieve, weigh according to the proportion, and mix uniformly in equal amounts; (b) starch, microcrystalline cellulose, low-substituted hydroxypropyl Base cellulose and mannitol pass through a 80-mesh sieve, weigh according to the proportion, mix evenly, prepare 5% polyvinylpyrrolidone as a binder, wet granulate, granulate with a 16-mesh sieve, dry, and granulate with a 24-mesh. (a) and (b) Two parts are added in equal amounts, mixed evenly, compressed into tablets, and coated.

Embodiment 3

[0037]

[0038]

[0039] Tablet preparation process: (a) pass the main ingredient and magnesium stearate through an 80-mesh sieve, weigh according to the proportion, and mix uniformly in equal amounts; (b) starch, cross-linked polyvinylpyrrolidone, low-substituted hydroxyl Propyl cellulose and dextrin pass through 80-mesh sieve, weigh according to the proportion, mix evenly, prepare 5% hydroxypropyl cellulose as a binder, wet granulate, granulate with 16-mesh sieve, dry, and granulate with 24-mesh . (a) and (b) Two parts are added in equal amounts, mixed evenly, compressed into tablets, and coated.

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Abstract

The invention belongs to the technical field of medicaments and relates to a losartan potassium troche and a preparation method thereof. In components of the troche, 10-30% of losartan potassium is used as a primary medicine in percentage by weight; magnesium stearate is used as a lubricant, wherein the ratio of the magnesium stearate to the losartan potassium is 1:10-1:25 in percentage by weight. A wet granulation technology and a tabletting technology with the primary medicine externally used are adopted in the preparation process. The invention aims at providing the troche with stable quality and simple and feasible process.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a stable losartan potassium preparation and a preparation method thereof. technical background [0002] Angiotensin II is the main active substance of the renin-angiotensin system, a potent vasoconstrictor, and plays a major role in the pathophysiological process of hypertension. Angiotensin II binds to AT1 receptors in various tissues (eg, vascular smooth muscle, adrenal gland, kidney, and heart), producing a variety of important biological effects including vasoconstriction and aldosterone release. At the same time, it can also stimulate the proliferation of smooth muscle cells. [0003] Losartan Potassium is a synthetic derivative of biphenyltetrazolium compounds, which belongs to the first orally effective and highly selective angiotensin II receptor (AT1 type) antagonist of non-peptide type. Its structural formula is: [0004] [0005] Its pharmaco...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4178A61K47/12A61P9/12
Inventor 马文武郭夏宋雪梅
Owner 北京万全阳光医药科技有限公司
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