Losartan potassium gastric floating capsule and preparation method thereof
A technology of losartan potassium and gastric floating, which is applied in the direction of medical formulas, medical preparations containing active ingredients, etc., and can solve the problems of increased frequency of taking medicine, lower patient treatment compliance, and hygroscopicity. Strong and other problems, to achieve the effect of small peak and valley fluctuations in blood concentration, reduce the number of medications taken, and increase the release time
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Embodiment 1
[0021] A losartan potassium gastric floating capsule, which comprises the following components, and the parts by weight of each component according to the amount used in 1000 capsules are:
[0022]
[0023] The losartan potassium is the losartan potassium granules obtained by passing through a 100-mesh sieve.
[0024] The preparation of losartan potassium gastric floating capsule is prepared by the following method:
[0025] S1. Mix PEG6000, stearic acid, and stearyl alcohol in proportion, and heat to 64°C until it melts into liquid;
[0026] S2. Raise the temperature of the liquid mixture to 72° C. and keep it for 9 minutes;
[0027] S3. Add a proportional amount of losartan potassium to the liquid mixture obtained in step S2, keep the temperature at 72°C, and stir evenly;
[0028] S4, add precrossified starch and mannitol in a proportional amount, and stir evenly;
[0029] S5. After the uniformity is qualified, fill it while it is hot, cover the capsule cap, and cool t...
Embodiment 2
[0031] A losartan potassium gastric floating capsule, which comprises the following components, and the parts by weight of each component according to the amount used in 1000 capsules are:
[0032]
[0033] The losartan potassium is the losartan potassium granules obtained by passing through a 100-mesh sieve.
[0034] Losartan Potassium Gastric Floating Capsules are prepared by:
[0035] S1. Mix PEG6000, stearic acid, and stearyl alcohol in proportion, and heat to 65°C until it melts into a liquid;
[0036] S2. Raise the temperature of the above liquid mixture to 70° C. and keep it for 10 minutes;
[0037] S3. Add a proportional amount of losartan potassium to the liquid mixture obtained in step S2, keep the temperature at 70° C., and stir evenly;
[0038] S4, add precrossified starch and mannitol in a proportional amount, and stir evenly;
[0039] S5. After the uniformity is qualified, fill it while it is hot, cover the capsule cap, and cool to room temperature.
[004...
Embodiment 3
[0042] A losartan potassium gastric floating capsule, which comprises the following components, and the parts by weight of each component according to the amount used in 1000 capsules are:
[0043]
[0044]
[0045] The losartan potassium is the losartan potassium granules obtained by passing through a 100-mesh sieve.
[0046] Losartan Potassium Gastric Floating Capsules are prepared by:
[0047] S1. Mix PEG6000, stearic acid, and stearyl alcohol in proportion, and heat to 66°C until it melts into a liquid state;
[0048] S2. Raise the temperature of the above-mentioned liquid mixture to 69° C. and keep it for 11 minutes;
[0049] S3. Add a proportional amount of losartan potassium to the liquid mixture obtained in step S2, keep the temperature at 69° C., and stir evenly;
[0050] S4, add precrossified starch and mannitol in a proportional amount, and stir evenly;
[0051] S5. After the uniformity is qualified, fill it while it is hot, cover the capsule cap, and cool ...
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