Compound preparation containing losartan potassium and hydrochlorothiazide and preparation method for compound preparation
A technology of hydrochlorothiazide and losartan potassium, which is applied in the field of medicine, can solve problems such as the increase of related substances, and achieve the effects of high bioavailability, fast dissolution and good stability
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Embodiment 1
[0031] (1) Prescription
[0032] (Based on 1000 pieces)
[0033]
[0034] Coating Composition
[0035] Opadry (stomach dissolving type) 7g
[0036] water 100ml
[0037] (2) Preparation method
[0038] 1) Pulverize losartan potassium and hydrochlorothiazide respectively, sieve, and set aside; sieve microcrystalline cellulose, lactose, low-substituted hydroxypropyl cellulose, and magnesium stearate, respectively, and set aside;
[0039] 2) Weigh the raw and auxiliary materials according to the prescription quantity;
[0040] 3) Mix the raw and auxiliary materials in 2) evenly, and press into tablets;
[0041] 4) Put the sample obtained in 3) into a coating pan, and coat it to obtain.
Embodiment 2
[0042] Embodiment 2 (comparative example)
[0043] (1) Prescription
[0044] (Based on 1000 pieces)
[0045]
[0046] Coating Composition
[0047] Opadry (stomach dissolving type) 7g
[0048] water 100ml
[0049] (2) Preparation method
[0050] 1) Pulverize losartan potassium and hydrochlorothiazide respectively, sieve, and set aside; sieve microcrystalline cellulose, lactose, low-substituted hydroxypropyl cellulose, and magnesium stearate, respectively, and set aside;
[0051] 2) Weigh the raw and auxiliary materials according to the prescription quantity and mix them evenly;
[0052] 3) dissolving hypromellose in 80% aqueous ethanol;
[0053] 4) Mix the product obtained in step 2) and step 3) uniformly, granulate with a 20-mesh screen, dry at 60°C, granulate with a 18-mesh screen, add magnesium stearate, and tablet;
[0054] 5) Put the sample obtained in 4) into a coating pan, and coat it to obtain.
[0055] Example 1 was prepared by the direct powder compression ...
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