39 results about "Isobutyramide" patented technology

The invention relates to the field of medicine and chemical industry, in particular to a preparation method of thioisobutyramide. In the present invention, isobutyramide is reacted with phosphorus pentasulfide under normal temperature and normal pressure under alkaline conditions, and the thioisobutyramide is synthesized in high yield, the yield is ≥90%, and the content is ≥99%.

A sulphonyl tetrazole compound 7 with the following structure, its preparation method and its use for preparing laetispicine. The said sulphonyl tetrazole compound 7, (1-phenyl-5-(3,4-methylenedioxyphenyl ethyl) sulphonyl tetrazole), is obtained from piperonal as raw material and by steps of Darzens condensation, hydrolysis, decarboxylation, reduction, condensation and oxidation. Laetispicine is prepared from the said compound as raw material, by condensation with 9-carbonyl-2E-4E-nonadienoic acid isobutyramide (compound 14), or by reaction with 5-(tetrahydropyran-2-oxo) n-pentanal (compound 10), deprotection, Swern oxidation, Wittig-Horner reaction, hydrolysis and amidation. As shown in H NMR, C NMR, MS and IR, the laetispicine prepared from the above-said compound is consistent with the laetispicine extracted from natural products.

The present invention discloses a vulcanizing agent preparing and deodorizing method for hydrogenation catalyst ex-situ pre-vulcanizing. The vulcanizing agent preparing and deodorizing method comprises vulcanizing agent synthesis and vulcanizing agent deodorizing, wherein excessive ammonia water is adopted as a catalyst, isobutene and sulphur are subjected to addition to produce the main product vulcanizing agent and concurrently produce the byproduct isobutyramide, and the physical method treatment technology of gas stripping and the chemical method treatment technology of hydrogen peroxide oxidation and ethylene carbonate treatment are used to carry out combined deodorizing on the vulcanizing agent. According to the present invention, the physical method treatment technology of the gas stripping and the chemical method treatment technology of the hydrogen peroxide oxidation and the ethylene carbonate treatment are used to carry out combined deodorizing, such that mercaptan, thioketone, thio thioketone and other odor components in the coarse vulcanizing agent product can be effectively removed so as to effectively reduce the odor; and after the reaction, the catalyst and the product are easily separated, the ammonia water can be recovered and recycled, the wastewater and the waste gas are not produced, only a small amount of the waste residue is produced during the filtering, and the isobutyramide product with the purity of more than 95% can be obtained by carrying out the crystallization purification treatment on the waste residue.

The invention discloses a method for preparing isobutyrylamide thiazolyl resorcinol, comprising the following steps: (1) reacting resorcinol and bromoacetic acid under the action of a catalyst to generate an intermediate shown in formula I; ( 2) thiourea reacts with isobutyryl chloride to generate the intermediate shown in formula II; (3) the intermediate shown in formula I and the intermediate shown in formula II are reacted under the action of a base to generate isoform shown in formula III. Butanamidothiazolyl resorcinol. The synthesis steps provided by the invention are simplified to three-step reactions, the process route is simple, the raw materials are readily available, the reaction time is short, the post-processing is convenient, the purity is over 99%, the total yield is over 29.1%, the operation is simple, and it is suitable for continuous industrial production. .