35 results about "Piperonal" patented technology

The invention relates to a preparing method of a phosphodiesterase 5 inhibitor tadalafil. D-methyl tryptophanate hydrochloride is adopted as an initial raw material, and is subjected to cyclization with heliotropin, N-acylation, aminolysis-cyclization, and other reactions to obtain a tadalafil crude product. The tadalafil crude product is recrystallized to obtain a tadalafil finished product. The method has characteristics of mild reaction conditions, short reaction time, high yield, good product stability and convenience for industrial production.

Pest control compositions, blends, and formulations are disclosed. The blends contain, in a synergistic combinations, at least two ingredients such as Lilac Flower Oil, D-Limonene, Thyme Oil, Lime Oil, Black Seed Oil, Wintergreen Oil, Linalool, Tetrahydrolinalool, Vanillin, Isopropyl myristate, Piperonal (aldehyde), Geraniol, Geraniol 60, Triethyl Citrate, and Methyl Salicylate.

The invention relates to a method of preparing piperonal in a one kettle way, which is a technical improvement of using 1,2-(methylenedioxy) benzene as a raw material to synthesize the piperonal. By the measures of selecting a proper solvent, adding an additive, diluting a reaction solution, and the like, the intermediate 3,4-(methylenedioxy) mandelic acid can be directly oxidized without being separated and purified to synthesize the piperonal in the 'one kettle' way. The invention has the characteristics of simple operation, high yield and the like, and both the purity and the quality of theproduct meet the requirements.

The invention relates to a method of preparing piperonal in a one kettle way, which is a technical improvement of using 1,2-(methylenedioxy) benzene as a raw material to synthesize the piperonal. By the measures of selecting a proper solvent, adding an additive, diluting a reaction solution, and the like, the intermediate 3,4-(methylenedioxy) mandelic acid can be directly oxidized without being separated and purified to synthesize the piperonal in the 'one kettle' way. The invention has the characteristics of simple operation, high yield and the like, and both the purity and the quality of the product meet the requirements.

The invention relates to the technical field of industrial wastewater treatment, and specifically discloses a treatment method for piperonal production wastewater. The method for treating the piperonal production wastewater includes: adding 1,2-methylenedioxybenzene to the piperonal production wastewater, mixing uniformly, performing distillation, collecting fractions, and separating liquids to obtain recovered materials; cooling the remaining mother liquor from the distillation , After adjusting the pH to weak acidity, adding transition metal oxides, performing high-pressure pulse treatment, filtering, and treating the treated water through the sewage treatment system and discharging. The method for treating wastewater from piperonal production provided by the invention has the advantages of simple process operation and low energy consumption, and solves the problem that the reaction raw materials and reaction products in the wastewater cannot be recovered by the traditional treatment process, and the treated wastewater can reach the level of "Chemical Synthesis Pharmaceutical Industry" "Water Pollutant Discharge Standard" discharge standard, will not cause secondary pollution, realize the comprehensive treatment and resource utilization of wastewater, has high economic and environmental benefits, and has high promotion value.

The invention provides a preparation method of piperonal, comprising: reacting piperonyl cycline, a catalyst and urotropine in an alcohol solvent at 50-120° C. for 1-10 hours to obtain piperonal. The overall process only needs one-step reaction, the process is simplified, the yield is high, the discharge of three wastes is relatively low, the waste water is easy to treat, and it is easy to realize industrial production.

The invention relates to a heliotropin biosynthesis method utilizing recombinant escherichia coli, and belongs to the technical filed of biological engineering. The method is characterized in that anoxidase gene derived from pseudomonas is introduced into escherichia coli. The recombinant bacterium can catalyze heliotropin synthesis from propenylbenzene, and the concentrated of the produced heliotropin is 9.15 g / L. The method in which the heliotropin is synthesized by utilizing recombinant oxidase has characteristics of a short production period, and simple extraction, and has a good industrial production prospect.

The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxy-benzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.

The preparation method for cyan-free silver plating lustre-coating agent comprises: adding 0.1-1mol / L heliotropin into saturated 0.1-2mol / L NaHSO3 solution for ultrasonic oscillating; dissolving 0.1-2mol / L triethanolamine and 0.1-1mol / L butynediol into the solution, adding solvent to dilute to 1L. This invention overcomes the defects in prior art withnot sulfur-containing compound, and has well dispersion.

The invention relates to an asymmetric synthesis method of (+)-tanshinol, which comprises the following steps: carrying out Knoevenagel condensation on the raw material heliotropin, hydrolyzing for ring opening to obtain beta-(3,4-3,4-methylenedioxyphenyl)pyruvic acid, carrying out key asymmetric reduction reaction to obtain R-beta-(3,4-dibenzyloxyphenyl)-alpha-hydracrylic acid, and finally, deprotecting to obtain the (+)-tanshinol. The method has the advantages of accessible raw material and high optical purity of the product, is simple to operate, and can implement large-scale preparation.

The invention discloses a method for preparing difluoro piperonal by utilizing a continuous flow microchannel reactor. The method for preparing the difluoro piperonal by utilizing the continuous flow microchannel reactor comprises the following steps: respectively introducing difluoro piperidine organic solvent solution and n-hexane solution of n-butyllithium into a precooling module of a microchannel reactor by virtue of a metering pump to be precooled, then enabling the difluoro piperidine organic solvent solution and n-hexane solution of n-butyllithium to enter a first mixing module for reacting, after reaction is finished, enabling reaction products to enter a second mixing module for reacting with N,N-dimethyl formamide, acidifying, extracting, and distilling, so that the difluoro piperonal is obtained. The method for preparing the difluoro piperonal by utilizing the continuous flow microchannel reactor has the advantages of short reaction time, easiness and safety in operation and low production energy consumption.

The invention relates to a process for obtaining compounds derived from tetrahydro-β-carboline, specifically tadalafil and intermediate products from the synthesis, comprising the reaction between piperonal and an alkyl ester of D-tryptophan as a salt, and in the absence of any other component, followed by haloacetylation and a final cyclization with methylamine.

The invention belongs to the field of food additives and provides a preparation method of a sesamol intermediate heliotropin. The preparation method is convenient to use by taking nitric acid as a decarboxylating agent; the product, namely the sesamol intermediate heliotropin is good in purity; especially the decarboxylation efficiency is high, so that the decarboxylation reaction can be efficiently carried out to directly influence the synthesis yield of the overall preparation route; compared with other synthesis routes, the heliotropin synthesis route disclosed by the invention has considerable advantage on the cost, and the product competitiveness is relatively strong. The synthesis method disclosed by the invention has the advantages of cheap raw materials, simple reaction process and high yield and can be applied to large-scale synthesis of sesamol.

The invention discloses a method for preparing tadalafil by a one-pot method. Using D-tryptophan methyl ester hydrochloride and piperonal as starting materials, a high-purity compound I with a single configuration is obtained through Pictet-Spengler reaction Hydrochloride, and then acylated with chloroacetyl chloride in an organic base system of an aprotic solvent to obtain a mixed reaction solution. The mixed reaction solution is not treated and directly added to methylamine solution to undergo an aminolysis and cyclization reaction. After the reaction, cooling crystallization Later got tadalafil. The method of the invention reduces the amount of solvent used, thereby effectively controlling the discharge of waste liquid, which is beneficial to environmental protection; the production cycle is shortened, the process efficiency is improved; the yield is increased and the cost is reduced. Compared with the existing process route, the present invention is more environmentally friendly, has higher efficiency and lower cost, and is more suitable for industrial production.