53 results about "Febrile convulsions" patented technology

The invention discloses an externally-used plaster for treating infantile febrile convulsion. The externally-used plaster is characterized in that bulk pharmaceutical chemicals of the formula weight are grinded into powder, then wine with the alcoholic strength lower than 40 degrees is slowly dropped into the medicine powder to stir the medicine into paste while the wine is dropped. The bulk raw materials comprises by weight proportion: 0.5-2 parts of amber, 2 parts of pearl, 1 part of bezoar, 1 part of rhinoceros horn, 1 part of stiff silkworm, 1 part of periostracum cicada, 1 part of bulbus fritilariae, 1 part of pericarpium citri reticulatae, 0.5-1 part of bryozoatum, 2 parts of fructus piperis alba, 0.5-2 parts of fructus evodiae or 0.5-2 parts of concretio silicea bambusae and / or 0.5-2 parts of arisaema cum bile, 2 parts of sticky rice, 0.5-2 parts of jasmine or 0.5-2 parts of rheum officinale and 0.5-2 parts of uncaria rhynchophylla or 0.5-2 parts of gastrodia elata. The externally-used plaster for treating infantile febrile convulsion is good in effect of preventing and treating infantile convulsion, free of side and toxic effects, wide in medicine source and moderate in cost, has the effect of wind dispelling, resuscitation inducing, dizziness relieving, convulsion relieving, tranquilizing and excitement allaying, phlegm cleansing and spasmolysis, and is suitable for children patients, and the cure rate is as high as 95%.

The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for inducing and maintaining anesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.

The invention relates to a traditional Chinese medicinal preparation for treating febrile convulsion and a preparation method of the Chinese medicinal preparation. The effective components of the traditional Chinese medicinal preparation comprise the following raw materials: serissa serissoides, ox-gall, rhizoma calami, manyleaf paris rhizome, cryptotympana atrata fabricius, drymotaenium miyoshianum, buta graveolens, white gourd, phymatopteris crenatopinnata, lotus, pinkflush rhododendron root, radix prismatomeris connatae, red-spotted stonecrop, elaeagnus conferta roxb, birch bark and loquat. The traditional Chinese medicinal preparation is appropriate in medicinal material compatibility, accords with traditional Chinese medical and modern medical theories, has the effects of tonifying the spleen and kidney, expelling wind and clearing heat, relieving convulsion and spasm, clearing heart and inducing resuscitation, has remarkable effect on treating febrile convulsion caused by intracranial infection, encephalopathia toxica, epilepsy, cerebral parasitic disease, hypertensive encephalopathy, poisoning, brain tumor and the like, has the advantages of short course of treatment, high safety and no toxic or side effect, is in favor of reducing the syndrome of an infected child in time, and has the effect of preventing relapse after febrile convulsion is healed.

The invention provides a traditional Chinese medicine composition for treating pediatric febrile convulsion and a preparation method and application of the traditional Chinese medicine composition for treating pediatric febrile convulsion. The traditional Chinese medicine composition comprises medicinal materials including Cornu Saigae Tataricae, Bombyx Batryticatus, Bile Arisaema, pearl powder, borneol, Calculus Bovis, succinum, Rhizoma Acori Tatarinowii and the like. By a great quantity of experimental optimization formulations, according to pharmacodynamic experiments, the traditional Chinese medicine composition has excellent antipyretic, sedative and anti-convulsion effects; according to experimental results, the traditional Chinese medicine composition is stable and outstanding in clinical efficacy in treatment of pediatric febrile convulsion, safe, free of toxic and side effects and capable of treating both symptoms and root causes and effectively preventing relapse, thereby having a broad clinical application prospect.

The invention belongs to technical field of medicines and relates to application of sitagliptin phosphate in preparation of a medicament for preventing and treating febrile convulsion. Currently, the sitagliptin phosphate has obvious medicament effect of clinically treating the febrile convulsion, but various serious side effects can be produced to damage children, and the tolerance and the addiction can be produced after long-time use. The product disclosed by the invention is definite in active ingredients, lower in cost and easy to implement.

The invention discloses application of zephyranthes candida in purifying livestock breeding biogas slurry, which belongs to the field of wastewater processing. The zephyranthes candida is planted in a livestock breeding biogas slurry pollution environment; and the function of the zephyranthes candida for absorbing pollution matters such as NH4+-N, TN, TP, CODcr in the livestock breeding biogas slurry, and the characteristics that the zephyranthes candida has tenacious vitality, can be planted directly, has no need to be managed specially, and is perennial are fully utilized, so that the problem of livestock breeding biogas slurry pollution is solved permanently. The investment is small, the operation cost is low, the effect is good, the operation is simple and easy to realize, the purifying effect in winter is ensured, and meanwhile, the secondary pollution can be avoided. The harvested zephyranthes candida has certain medicinal value, and can be used for treating febrile convulsion and epilepsy. The zephyranthes candida is utilized for processing wastewater, and the environment protection is combined with landscape construction and economic construction, so that a sustainable development idea taking consideration of sewage processing, ecological restoration, landscape construction and economic benefit is embodied, which is profound.

A device and method for detecting febrile convulsions, the device including a detector for detecting motion of the device and providing an output corresponding thereto, a capacitor coupled to the detector and charged by the output of the detector, a resistor coupled to the capacitor to provide discharge of the capacitor, a comparator for comparing a voltage level of the capacitor to a reference voltage and providing a signal when the voltage level of the capacitor is greater than the reference voltage, and an indicator driven by the signal from the comparator to provide an indication of febrile convulsions.

The invention discloses a compound external anti-ulcer tablet which is characterized by comprising the following components by percent: 15 percent of oxytetracycline, 15 percent of berberine, 10 percent of compound sulfamethoxazole, 10 percent of metronidazole, 15 percent of complex vitamin B, 15 percent of vitamin C, 10 percent of cimetidine, 7 percent of calcium and 3 percent of chlortrimeton. The compound external anti-ulcer tablet solves the problems that an existing external anti-ulcer tablet cannot be used for treating skin membrane ulcer such as bedsore, scald, and non-cicatrization of wounds, and is applicable to treatments of various infantile febrile convulsion patients.

The invention provides a drug for treating febrile convulsion in children. The drug comprises the following components in parts by weight: 10-20 parts of gambir plant, 6-12 parts of white stiff silkworm, 8-15 parts of pinellia tuber, 8-12 parts of Chinese honeylocust fruit, 2-5 parts of musk, 6-12 parts of arisaema cum bile, 8-16 parts of radix adenophorae, 6-12 parts of dwarf lilyturf tuber, 1-3 parts of bezoar and 9-12 parts of liquorice. The drug has the advantages and positive effects of obvious treatment effects, high effect taking speed and small side effects.

The invention relates to the field of tradtional Chinese medical science and traditional Chinese medicines, and discloses a traditional prescription for preventing the recurrence of infantile febrile convulsion. The traditional prescription is prepared by taking radix codonopsis pilosulae, fried bighead atractylodes rhizome, poria cocos, clean licorice, astragalus mongholicus, Chinese yams, fructus alpiniae oxyphyllae, polygala tenuifolia, bile arisaema, rhizoma typhonii, scorpion and stiff silkworms as raw materials. The traditional prescription concurrently takes both symptoms and root causes into consideration, and has the effects of invigorating spleen and supplementing qi, relieving dizziness and calming the mind, eliminating phlegm and dredging collaterals. The traditional prescription has a good clinical application effect, can effectively reduce the recurrence of infantile febrile convulsion, and has no adverse reaction, and the compliance of infant patients is good, therefore, for numerous infant patients with febrile convulsion, the traditional prescription has considerable market potentials and social benefits.

The invention relates to a traditional Chinese medicine for treating infantile febrile convulsion. The traditional Chinese medicine is characterized by containing the following ingredients in percentage by weight: 1 fresh ox gall bladder, 25-40% of stiff silkworm, 25-40% of coptis root and 25-40% of cicada slough. The traditional Chinese medicine is used for solving the problem that infantile febrile convulsion, of which the pathogenesis is not clear yet, can not be prevented and can not be controlled, and is applicable to the treatment of various patients suffering from the infantile febrile convulsion.

The invention provides a child drug pillow for preventing recurrence of a febrile convulsion. The child drug pillow for preventing the recurrence of the febrile convulsion is formed by firstly smashing, then evenly mixing and finally bagging traditional Chinese medicine of uncaria, cicada slough, nacre mother of pearls, divaricate saposhnikovia roots, white paeony roots, fried jujube kernels, dried radix rehmanniae, adenophora verticillata, radix ophiopogonis, radix asparagi, radix trichosanthis, nourishing yin medicine, mint, round cardamom, liquorice, Chinese angelica, peach kernels and lalang grass rhizomes. The child drug pillow for preventing the recurrence of the febrile convulsion has good cure rate for the febrile convulsion of a child, especially can prevent the recurrence of the febrile convulsion, causes no toxic and side effect, is convenient to use and low in cost, and reduces expense burdens of patients.

The invention discloses a traditional Chinese medicine composition for treating febrile convulsion. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 11-12 parts of radix ophiopogonis, 8-10 parts of dogwood, 5-7 parts of semen raphani, 4-6 parts of honeysuckle, 3-4 parts of radix curcumae, 2-4 parts of liquorice, 4-6 parts of polygala tenuifolia, 4-6 parts of gastrodia elata, 2-4 parts of uncaria, 10-12 parts of luffa stem, 10-12 parts of cucumber stem, 4-5 parts of chickweed, 2-4 parts of clerodendrum lindleyi, 4-6 parts of Centella aslatlca Urban, 1-3 parts of murdannia triquetra, 6-8 parts of artemisia argyi and 2-3 parts of dichondra repens. The traditional Chinese medicine composition is simple in preparation, good in absorption effect, obvious in curative effect and high in safety, does not have side effects, has the effects of nourishing yin, moisturizing lung, tonifying stomach, promoting fluid, clearing away the heart-fire, relieving restlessness, tonifying the liver and kidneys and converging solid doff, and has an obvious treatment effect on the febrile convulsion.

The invention authenticates a new pathogenic gene-PRRT2 related with febrile convulsion. Specifically, a four-generation Chinese family of febrile convulsion dominant inheritance is used as a research object, sick individuals and non-sick individuals in the family are subjected to exome sequencing and comparison, a frame-shift insertion mutant c.641insC(p.R217Pfs*8) is discovered in the PRRT2 gene, and the mutant causes the change of a PRRT2 protein. Based on condition, the invention provides a mutant PRRT2 gene as well as a coding protein and application thereof, including a vector of the mutant PRRT2 gene, a host cell and a kit. The febrile convulsion can be subjected to molecular diagnosis and sickening risk evaluation by using the mutant PRRT2 gene. The mutant gene and the coding protein thereof can also be used as medicament targets for treating febrile convulsion.

The invention provides application of a benzamide derivative and pharmaceutical salt thereof in preparing a Caspase-1 selective inhibitor and anti-convulsion medicine. The novel Caspase-1 selective inhibitor 3-(3-(thiophene-2-formamide)benzamido)methyl benzoate is obtained through screening, it is provided through molecule, cell and whole animal level experiments that 3-(3-(thiophene-2-formamide)benzamido)methyl benzoate can effectively inhibit Caspase-1 enzyme activity, inhibit the attack of febrile convulsions of whole animals, prolong the latent time of the attack of febrile convulsions, increase the threshold value of the attack of febrile convulsions and decrease the proportion of the attack of febrile convulsions, and has no obvious acute or chronic toxic or side effect, and an experimental basis is provided for application of 3-(3-(thiophene-2-formamide)benzamido)methyl benzoate in treating febrile convulsions.

The invention provides a pharmaceutical composition for treating epileptiform convulsion, febrile convulsion. The pharmaceutical composition comprises medical extract and auxiliary materials, whereinthe auxiliary materials are selected from one or two of calcium carbonate and calcium hydrophosphate; based on the weight of the medical extract, the weight fraction of the auxiliary materials is 10%;the medical extract is prepared by extracting the following traditional Chinese medicinal materials: astragalus, codonopsis pilosula, salviae miltiorrhizae, radix bupleuri, spina date seed, polygalatenuifolia, rhizoma gastrodiae, uncaria rhynchophylla, rhizoma acori graminei, arisaema cum bile, angelica sinensis, stiff silkworm, medicated leaven, radix curcumae, liquorice and giant typhonium rhizome. The pharmaceutical composition provided by the invention is uniform and smooth in flow, and when the composition is prepared into capsules, the adhesive powder punch pole condition is obviouslyimproved, so that the filling process is stabilized, the content uniformity range of the filled capsules is narrow, and the long-term stability of the capsules is excellent.

The invention discloses a convulsion and spasm relieving preparation for treating infantile febrile convulsion and a preparation method thereof. The preparation is mainly prepared from the following medicinal raw materials in parts by weight: 10-20 parts of fructus forsythiae, 6-9 parts of carpesium abrotanoides, 12-25 parts of periostracum cicadae, 4-6 parts of amber, 9-15 parts of trichosanthes peel, 3-6 parts of tylophora florlbunda, 5-9 parts of annual fleabane herb, 2-4 parts of carapax eretmochelyos, 8-12 parts of radix crepidis ligneae, 4-9 parts of zornia diphylla pers and 10-20 parts of irkutsk anemone rhizome. All preparations are simple in preparation method, are prepared from easily available materials and do not have toxic or side effect, the formula is prepared according to the principle of traditional Chinese medicine, and has the effects of clearing heat, removing toxicity, inducing resuscitation, concentrating, relieving convulsion, tranquilizing and the like. The preparation has exact curative effect, is safe, does not have side effect, and can be used for preventing relapse.

The invention relates the field of foods and especially relates to globe amaranth flower moon cake stuffing and a manufacturing method thereof. The globe amaranth flower moon cake stuffing comprises one or more main materials, an auxiliary material and food additives. The one or more main materials are selected from kernels, lotus seeds and beans. The auxiliary material is globe amaranth flower. The manufacturing method of the globe amaranth flower moon cake stuffing comprises the following steps of processing globe amaranth flower, processing the one or more main materials and carrying blending. Globe amaranth flower adopted by the manufacturing method has effects of removing liver fire and improving eyesight, relieving cough and asthma, reducing blood pressure and expelling toxins, and maintaining beauty and keeping young. The manufacturing method has simple processes and can retain active ingredients of fresh globe amaranth flower to the maximum degree. The globe amaranth flower moon cake stuffing obtained by the manufacturing method has a unique fragrance of globe amaranth flower, and also has obvious effects of treating intermittent headache, eye pain, asthma and cough, dysentery, pertussis, children febrile convulsion, scrofula, and sore and ulcer.

A wearable child febrile convulsion monitoring device, including a belt, a body temperature measurement unit, a state measurement unit and an information processing unit, the belt is configured to be fixed with the subject to be monitored, and is used to connect the body temperature measurement unit and the state measurement unit in series and an information processing unit; the body temperature measurement unit includes a body temperature measurement sensor for measuring the body temperature of the object to be monitored; the state measurement unit includes at least one measurement module for measuring the ambient temperature of the object to be monitored, the surrounding humidity of the object to be monitored and the motion state of the object to be monitored ; The information processing unit is electrically connected with the body temperature measurement unit and the state measurement unit, and is used to process the state parameters measured by the body temperature and state measurement units. The device of the present invention can monitor the body temperature in real time to check whether the child has convulsions under high temperature, etc., so that parents can manage the growth of the child more conveniently and intelligently.

The present invention relates to novel benzimidazole derivatives of the formula (I) as defined in the description and in the claims, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for inducing and maintaining anaesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.

The invention discloses an antipyretic and antitoxic drug for febrile convulsion and a preparation method of the drug. The antipyretic and antitoxic drug is prepared from the following main raw material medicines in parts by weight: 12-25 parts of forsythia, 6-10 parts of polygala japonica, 4-8 parts of coptis, 6-9 parts of tylophora florlbunda, 10-20 parts of jasmine, 5-10 parts of peristrophe, 7-12 parts of uncaria, 8-15 parts of lactuca indica, 3-5 parts of amber, 9-12 parts of rhizoma anemarrhenae, 2-6 parts of calculus bovis and 5-10 parts of coralhead plant stem with leaf. The antipyretic and antitoxic drug quick becomes effective, and is short in treatment period, safe, free of toxic side effect, capable of treating both symptoms and root causes and is unlikely to recur.

The invention provides a traditional Chinese medicine composition for treating febrile convulsions in children and its preparation method and application. The traditional Chinese medicine composition contains medicinal materials such as antelope horn, zombie silkworm, binanxin, pearl powder, borneol, bezoar, amber, and calamus. The present invention optimizes the formula through a large number of experiments, and pharmacodynamic experiments prove that the traditional Chinese medicine composition provided by the present invention has good antipyretic, sedative and anticonvulsant effects. Experimental results show that the traditional Chinese medicine composition provided by the present invention has stable and outstanding clinical efficacy in treating febrile convulsions in children, can treat both the symptoms and root causes, can effectively prevent repeated attacks, is safe and has no toxic and side effects, and has broad clinical application prospects.

The invention discloses locust medicinal wine. The locust medicinal wine is prepared from rice wine with alcoholic strength above 50, locusts, rock candy, wolfberry, longan, ginseng slices and the like. The locust medicinal wine has a reasonable formula and is easy to produce. The locust medicinal wine has a clear wine body and slightly sweet fragrance, is brown yellow, has the efficacies of relieving cough and asthma, dispelling wind, eliminating dampness, relaxing tendons, activating collaterals, promoting blood circulation and removing blood stasis, is suitable for treating diseases of tetanus febrile convulsion, fever, asthma, acute filthy disease, chilblain, trachitis and the like, and can be used for preventing cardiovascular and cerebrovascular diseases and the like. The locust medicinal wine has very remarkable efficacies for treating cough, insomnia, frequent micturition and neurasthenia caused by cold.

The invention discloses an application of anoectochilus formosanus in treating rural combined domestic sewage, belonging to the field of wastewater treatment. The problem of rural combined domestic sewage pollution can be permanently solved by planting anoectochilus formosanus in the rural combined domestic sewage, absorbing pollutants such as NH4<+>-N, TN, TP and CODcr in the rural combined domestic sewage by making full use of anoectochilus formosanus, and using the perennation characteristic of anoectochilus formosanus. The application disclosed by the invention has the advantages of low investment, low running cost, good effect and simple and feasible operation. Harvested anoectochilus formosanus also can be applied to drug use, can be mainly used for treating difficult and complicated diseases such as lung heat cough, hemoptysis of pulmonary tuberculosis, hematuria, febrile convulsion of children, tetanus, nephritis edema, arthralgia due to wind-dampness, traumatic injury, poisonous snake bite, bronchitis, urocystitis, diabetes, hematuresis, acute or chronic hepatitis, rheumatoid arthritis and tumor, and also can be used for removing acnes. An operation mode that conventional ecological engineering depends on government to invest money all the year around can be expected to change by treating wastewater by using anoectochilus formosanus and combining environmental protection with economic construction, and thus the application has profound significance.

The invention discloses a preparation and administration of gall bladder-processed bombyx batryticatus. The preparation and administration are characterized by comprising the following steps: taking one fresh bovine gall bladder, filling the bovine gall bladder with the bombyx batryticatus, keeping in shade and hanging for one month, taking out bombyx batryticatus and finely grinding together with coptis chinensis and periostracum cicada, and blending into mushy state and administrating with warm water when children is attack. According to the preparation and administration of gall bladder-processed bombyx batryticatus, the problems that the pathogenesis of the infantile febrile convulsion is not clear, and infantile hyperpyrexia cannot be prevented and cannot be controlled can be solved, and the gall bladder-processed bombyx batryticatus is suitable for treating patients with barious infantile hyperpyrexia and convulsion.

The invention belongs to technical field of medicines and relates to application of sitagliptin phosphate in preparation of a medicament for preventing and treating febrile convulsion. Currently, the sitagliptin phosphate has obvious medicament effect of clinically treating the febrile convulsion, but various serious side effects can be produced to damage children, and the tolerance and the addiction can be produced after long-time use. The product disclosed by the invention is definite in active ingredients, lower in cost and easy to implement.

The invention relates to the technical field of establishment of an animal model used for screening drug and researching disease mechanism, in particular to a screening method of a febrile convulsion model rat, which can be used for obtaining the model rat by screening in a way of combining a typical water bath heating induction model with artificial directional selection and mating breeding. Themethod is unique and can be used for successfully obtaining the good febrile convulsion sensitive model rat and a tolerance model rat.