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67 results about "Disease stages" patented technology
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Stages of Alzheimer's Disease. Alzheimer’s disease is categorized in three main stages: mild, moderate, and severe. MILD -- People suffering from mild Alzheimer’s disease may appear to be healthy, but they actually have trouble making sense of their surroundings.
Methods and systems of using exosomes for determining phenotypes
InactiveUS7897356B2High sensitivityStrong specificityMicroorganismsMicrobiological testing/measurementTherapy relatedBiomarker (petroleum)
Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
Owner:CARIS LIFE SCI LUXEMBOURG HLDG
Adam12 as a biomarker for bladder cancer
InactiveUS20090029372A1Improve the level ofLower Level RequirementsMicrobiological testing/measurementMaterial analysisTissue ArraysAffymetrix genechip
The present inventors have shown that the gene and protein expression profiles of ADAM8, ADAM10 and ADAM12 in different grades and stages of bladder cancer.ADAM12 gene expression was evaluated in tumors from 96 patients with bladder cancer using a customized Affymetrix GeneChip. Gene expression in bladder cancer was validated using reverse transcription-polymerase chain reaction (RT-PCR), quantitative PCR, and in situ hybridization. Protein expression was evaluated by immunohistochemical staining on tissue arrays of bladder cancers.The presence and relative amount of ADAM12 in the urine of cancer patients were determined by Western blotting and densitometric measurements, respectively.Particularly ADAM12 mRNA expression was significantly upregulated in bladder cancer, as determined by microarray analysis, and the level of ADAM12 mRNA correlated with disease stage. ADAM12 protein expression correlated with tumor stage and grade. ADAM12 was present in higher levels in the urine from bladder cancer patients than in urine from healthy individuals. Significantly, following removal of tumor by surgery, in most bladder cancer cases examined the level of ADAM12 in the urine decreased and, upon recurrence of tumor, increased.
Owner:PHYSICIANS CHOICE LAB SERVICES +1
Methods and systems for determining phenotypes using exosomes
InactiveCN102301002AMicrobiological testing/measurementDisease diagnosisTherapy relatedBiomarker (petroleum)
Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
Owner:CARIS LIFE SCI LUXEMBOURG HLDG
Anti-inflammatory and keeping adverse energy downwards capsule for treating asthma, pulmonary emphysema and SARS
The capsule for treating asthma, pulmonary emphysema and SARS is developed based on the principle that the Chinese medicine and the Western medicine are complementary and synergistic, and compounded with several kinds of Chinese medicines and Western medicines. It can kill bacteria, resist virus, eliminate circulating disturbance and regulate immunity, and suitable for various people in different disease stages. It has high and stable curative effect. In addition, it has also certain treating effect on hypertension, angiosclerosis, wind-wetness Bi syndrome, etc.
Owner:梁海东
Device, Array, And Methods For Disease Detection And Analysis
InactiveUS20080200342A1Sequential/parallel process reactionsLibrary screeningBiomarker (petroleum)Phases of clinical research
A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
Owner:LAWRENCE LIVERMORE NAT SECURITY LLC
Medical record data processing method, apparatus and system
ActiveCN105389465AReduce delaysMedical data miningSpecial data processing applicationsHand-foot-and-mouth diseaseMedical record
Owner:徐翼 +1
Neoepitope detection of disease using protein arrays
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of determining efficacy of a pharmaceutical for treating a disease or staging disease by administering a pharmaceutical to a sample containing markers for a disease, detecting the amount of at least one marker of the disease in the sample, and analyzing the amount of the marker in the sample, whereby the amount of marker correlates to pharmaceutical efficacy or disease stage. Markers for gynecological disease. An immuno-imaging agent comprising labeled antibodies, whereby the labeled antibodies are isolated and reactive to proteins overexpressed in vivo. Informatics software for analyzing the arrays, the software including analyzing means for analyzing the arrays.
Owner:TAINSKY MICHAEL +2
Health monitoring system and method
InactiveCN105286911AAvoid delayRealize health monitoringStethoscopeDiagnostic recording/measuringElectricityHealth index
The invention provides a health monitoring system and method, and relates to the technical field of medical treatment and health care. The health monitoring system comprises a data collecting module and an intelligent processing module electrically connected with the data collecting module. The health monitoring method includes the steps that the data collecting module collects health data of a human body and transmits the health data to the intelligent processing module, and the intelligent processing module performs analysis and processing according to the health data to obtain the health condition index and focus characteristics of the human body. By means of the health monitoring system and method, the health index of the cardiopulmonary system and body temperature of an infant can be intelligently analyzed, health monitoring in the initial disease stage, the treatment stage and the recovery stage is achieved, and treatment reference is provided for a parent and a doctor.
Owner:SHANGHAI TUOXIAO INTELLIGENT TECH
Model-based segmentation of an anatomical structure
ActiveUS20160063726A1Cope wellImprove fitImage enhancementImage analysisAnatomical structuresPattern recognition
A system (100) and method is provided for performing a model-based segmentation of an anatomical structure in a medical image of a patient. The medical image (022) is accessed. Moreover, model data (162) is provided which defines a deformable model for segmenting the type of anatomical structure. The model-based segmentation of the anatomical structure is performed by adapting the deformable model to the anatomical structure in the medical image using an adaptation technique. In accordance with the present invention, performing the model based segmentation further comprises determining from patient data (042) medical information which is predictive of an appearance of the anatomical structure in the medical image, and adjusting or setting a segmentation parameter based on the medical information so as to adjust the model-based segmentation to said predicted appearance of the anatomical structure in the medical image, the segmentation parameter being a parameter of i) the deformable model or ii) the adaptation technique. Advantageously, the system and method are enabled to better cope with the inter-patient and inter-disease-stage variability in the appearance of anatomical structures.
Owner:KONINKLJIJKE PHILIPS NV
Method for Identifying Protein Patterns in Mass Spectrometry
InactiveUS20100017356A1Reduce baseReduce signal noiseParticle separator tubesComponent separationDisease phasesHer Disease
The present invention refers to a medical diagnostic method based on proteomic and / or genomic patterns, using data obtained by mass spectrometry. The method also allows classifying the patients as to their disease stage Additionally, present invention also refers to two new biomarkers for the Hodgkin Disease medical diagnosis. Based on the SVM analysis, one localizes the windows of interest and later on uses the mass spectrum so to allow the biomarkers localization, so that the identification of said biomarkers occur by means of a 2D gel ou by mass spectrometry.
Owner:FUNDACAO OSWALDO CRUZ FIOCRUZ
Composition for enhancing immunity and preparation process of composition
InactiveCN103127304AImprove immunityImprove disease resistanceAnthropod material medical ingredientsBacteria material medical ingredientsPropolisSide effect
The invention aims at providing a composition which is prepared from mannatide, propolis, a medlar extract and an astragalus extract and is capable of enhancing immunity, as well as a preparation process of the composition. The mannatide, propolis, medlar extract and astragalus extract, which are scientifically compounded, are natural extracted materials, free from toxic and side effects to the body, free from incompatibility and complementary in effect to achieve a synergistic effect and a concrete treating effect. The composition is prepared to well improve immunity and disease resistance of the body, reduce disease outbreak, shorten treating course in disease stage and promote curing of the body, so as to further enhance immunity and disease resistance of audience bodies of human or warm-blooded animals.
Owner:丁国成
Novel transparent zebrafish and preparation method thereof
This invention provides a biological selective breeding technique in preparation of a transparent zebrafish, Citrine. The appearance of Citrine is transparent and yellowish, with uniformly pigmented black eyes and its inner organs are observable by eyes. The invention also provides a method for in vivo observation of progression and expansion of various disease stages or physiological processes.
Owner:NATIONAL TSING HUA UNIVERSITY
Disease risk automatic early warning method and system
PendingCN108766568AFacilitate health self-checkEasy to predictMedical communicationHealth-index calculationRisk levelDisease risk
The invention provides a disease risk automatic early warning method and system. The method includes acquiring and storing the user detection index data, the health evaluation conclusion and inquiry information, and searching the early warning rule matched with the data, inquiring the user information associated with the preset early warning rule, the historical data of the user detection indexes,acquiring the inquiry information when the early warning rule needed to be supported by the inquiry, finally integrating the user information, the user detection index data, the historical data of the user detection indexes, the health evaluation conclusion and inquiry information to obtain the risk levels of the early warning rule, sending the early warning information according to the risk levels of the early warning rule for the user to carry out health self-inspection and prediction, and improving the initiative of the user to monitor the health condition. According to the method, the corresponding early warning information is sent to the user at different disease stages, so that the user can take corresponding medical measures according to the health condition of the user, and the condition that the medical resources are tight is relieved.
Owner:来康科技(北京)有限公司
Neoepitope detection of disease using protein arrays
ActiveUS20050239146A1Reduce morbidityLow costBioreactor/fermenter combinationsPeptide librariesImaging agentDisease specific
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of determining efficacy of a pharmaceutical for treating a disease or staging disease by administering a pharmaceutical to a sample containing markers for a disease, detecting the amount of at least one marker of the disease in the sample, and analyzing the amount of the marker in the sample, whereby the amount of marker correlates to pharmaceutical efficacy or disease stage. Markers for gynecological disease selected from the list in Table 8. An immuno-imaging agent comprising labeled antibodies, whereby the labeled antibodies are isolated and reactive to proteins overexpressed in vivo. Informatics software for analyzing the arrays of claim 17, the software including analyzing means for analyzing the arrays.
Owner:WAYNE STATE UNIV
An Alzheimer's disease region detection method based on a convolutional neural network
InactiveCN109934804AGuaranteed correctnessImprove work efficiencyImage analysisNeural architecturesFeature extractionNMR - Nuclear magnetic resonance
The invention discloses an Alzheimer's disease region detection method based on a convolutional neural network. A focus detection task is divided into three steps of feature extraction, focus positioning and focus classification. The method comprises the following steps: training an improved AlexNet neural network model to extract the characteristics of an original brain nuclear magnetic resonanceimage and generate a characteristic pattern; Then training an area generation network model to generate propose used for positioning a lesion area of the brain nuclear magnetic resonance image; And then sending the feature map and propodal into a subsequent classification network for classification training, so as to classify which disease stage the lesion area is in. The result shows that the method has a good detection effect on the Alzheimer's disease region of the brain nuclear magnetic resonance image.
Owner:UNIV OF SCI & TECH BEIJING
Online intelligent diagnosis platform based on big data and operation method and storage medium thereof
ActiveCN110101361ASmall amount of calculationImprove accuracyMedical imagesInstrumentsComputer visionPathology diagnosis
The invention discloses an online intelligent diagnosis platform based on big data and an operation method and a storage medium thereof. The operation method comprises the steps that an eye ground image of a to-be-detected object is received; the eye ground image of the to-be-detected object is matched with standard eye ground images corresponding to all the stages of the disease; according to a matching result, the disease stage of the to-be-detected object is judged; a convolution kernel is selected in the disease stage of the to-be-detected object, and the selected convolution kernel is adopted for conducting convolutional neural network algorithm processing on the eye ground image of the to-be-detected object so as to extract pathology characteristic information; the pathology characteristic information is matched with data corresponding to the disease stage of the to-be-detected object in a database of a cloud platform so as to obtain intelligent diagnosis information. According to the technical scheme, the pressure of an ophthalmologist can be relieved, the diagnosis efficiency and accuracy can be improved, the calculation amount of the cloud platform is reduced, and the operation efficiency is improved.
Owner:SHENZHEN NEW IND MATERIAL OF OPHTHALMOLOGYCO
Digital disease management system
InactiveUS20080059234A1TherapiesComputer-assisted treatment prescription/deliveryPersonalizationData signal
The present invention relates to a method for improving the delivery of health care for patients. A first data signal being multimedia data which is indicative of a patient condition of a selected patient is input into a local computer. Clinical data, cost data and administrative data relating to the health of the selected patient is also input into the local computer. The first data signal is combined with the clinical data, cost data and administrative data to form a first patient information signal which is transmitted to a central computer. A predetermined disease stage is then assigned to the selected patient based on the first data signal. The disease stage is combined with the first patient information signal to form a second patient information signal. Then, a first array of risk factors is computed from a database containing a plurality of previously obtained individualized patient information records. A first predictive probability is then assigned to the selected patient based on the second patient information signal and the first array of risk factors. A first patient recommendation signal indicating one of the selected patient would benefit from immediate patient care and the selected patient would not benefit from immediate patient care is generated and then transmitted to the local computer. Both the second patient information signal and the first patient recommendation signal are transmitted to a regional computer in response to the first patient recommendation signal indicating that the selected patient requires immediate patient care.
Owner:THE BOARD OF RGT UNIV OF OKLAHOMA
Method of diagnosis, staging and monitoring of melanoma using microrna gene expression
InactiveCN111183235AMicrobiological testing/measurementDisease diagnosisPerformed DiagnosisMicroRNA Gene
The present invention relates to methods of diagnosing melanoma in a subject, the method comprising detecting microRNA expression levels. The present invention also relates to methods of assessing thedisease stage of melanoma and / or monitoring said melanoma stage. Also, the present invention relates to selecting a treatment or modifying a treatment based on the diagnosis or stage of melanoma. Further the present invention relates to a system for detecting and diagnosing melanoma in a patient and for determining the disease stage of melanoma.
Owner:GENESEQ PTY LTD
Compositions and methods relating to osteoarthritis
The invention provides for nucleic acid sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild osteoarthritic, moderate osteoarthritic, marked and osteoarthritic. The invention also relates to arrays and compositions comprising any combination of these nucleic acid sequences. The invention also provides for methods of using the arrays of the invention to diagnose osteoarthritis. The invention also provides for methods of identifying therapeutic agents that alter the level of expression of the nucleic acids of the invention or alter the anabolic level of a chondrocyte.
Owner:CHONDROGENE
Molecular markers for the diagnosis of Alzheimer's disease
The present invention provides methods for profiling mRNA production in single cells, in particular, during disease stages. The invention also provides a method for monitoring gene expression in a single cell which has been isolated from tissue. The methods of the present invention may be used to diagnose or monitor the progression of disease.
Owner:UNIVERSITY OF ROCHESTER
Method for preventing and curing round spots of panax notoginseng
InactiveCN105123345AIncrease productionImprove fertilityPlant protectionSoil treatmentCelastrus angulatus
The invention provides a method for preventing and curing round spots of panax notoginseng. The method includes ecological soil treatment by applying Difulai and Woyiduo, agricultural preventing and curing; physical preventing and curing; biological control by applying a biological source pesticide containing effective components, amounts by weight, of 20-30 parts of matrine, 10-15 parts of celastrus angulatus, 5-10 parts of derris trifoliate, 10-20 parts of avilamycin, 5-10 parts of pyrethrin and 1-3 parts of chitosan; biological preventing and curing by spraying polyoxin water solution after seedling emergence and leaf expansion, and chemical preventing and curing by alternatively spraying wettable mancozeb powder and metalaxyl-mancozeb wettable powder during initial disease stage. Pathogens in soil can be suppressed and reduced through agricultural preventing and curing and physical preventing and curing measures, and the growth environment is turned to be unsuitable for growing pathogens. Pathogens are killed through biological preventing and curing and chemical preventing and curing means timely, and the biological source pesticide can prevent insects from spreading pathogens. Excellent effects for preventing and curing round spots of panax notoginseng are ensured.
Owner:云南天质弘耕科技有限公司
Model-based segmentation of an anatomical structure
ActiveUS9824457B2Cope wellImprove fitImage enhancementImage analysisAnatomical structuresPattern recognition
A system (100) and method is provided for performing a model-based segmentation of an anatomical structure in a medical image of a patient. The medical image (022) is accessed. Moreover, model data (162) is provided which defines a deformable model for segmenting the type of anatomical structure. The model-based segmentation of the anatomical structure is performed by adapting the deformable model to the anatomical structure in the medical image using an adaptation technique. In accordance with the present invention, performing the model based segmentation further comprises determining from patient data (042) medical information which is predictive of an appearance of the anatomical structure in the medical image, and adjusting or setting a segmentation parameter based on the medical information so as to adjust the model-based segmentation to said predicted appearance of the anatomical structure in the medical image, the segmentation parameter being a parameter of i) the deformable model or ii) the adaptation technique. Advantageously, the system and method are enabled to better cope with the inter-patient and inter-disease-stage variability in the appearance of anatomical structures.
Owner:KONINKLJIJKE PHILIPS NV
Synchronous rehabilitation train device for upper and lower limbs
ActiveCN109200536AExercise leg musclesExercise coordinationChiropractic devicesStiltsTransmission beltEngineering
The invention relates to the technical field of medical and nursing instruments, in particular to a synchronous rehabilitation train device for upper and lower limbs. The synchronous rehabilitation train device includes a chassis, first rail, Handrails, saddles and lumbar pillows, A U-shape bar is fixedly connected at two end of that first cross bar, A foot pedal is sleeved in the middle of the U-shaped rod, the armrest lever is threadably connected above the armrest fixing lever, A motor is fixedly connected on the lower end face of the chassis, the power turntable and the forced turntable are connected with each other through a transmission belt, A brake screw is screwed on the left end surface of the chassis, the lower end of the saddle is fixedly connected to the telescopic upright post through a fixing seat, the right side of the adjusting pipe is screwed to the waist pillow adjusting screw, the right end surface of the waist pillow is fixedly connected to the waist pillow adjusting rod, and the waist pillow adjusting rod and the waist pillow adjusting screw are connected through bearings. The invention has reasonable structure design, and different training modes can be adopted for the patients in different disease stages, so that the rehabilitation training of the patients progresses step by step, which is beneficial to the stage recovery of the patients.
Owner:山东卫康生物医药科技有限公司
Disease Management Information System
InactiveUS20080103831A1Data processing applicationsHealth-index calculationInformation repositoryDocumentation procedure
A system automatically, provides a clinician with cancer specific staging criteria in response to a user selected cancer diagnosis name, calculates a stage of the disease in response to selection of particular staging criteria and associates treatments and clinical documentation with the cancer diagnosis and stage. A disease management information system includes a repository of information associating a combination of multiple disease progression indicators of a particular disease with an indicator identifying a particular stage of the particular disease. A data processor uses the repository in automatically determining a stage of a disease in a particular patient in response to receiving data identifying multiple disease progression indicators of the particular patient. The data processor stores data identifying the disease stage in a record associated with the particular patient for access by multiple healthcare workers at different locations.
Owner:SIEMENS MEDICAL SOLUTIONS USA INC
Auto-check method and system of retinopathy of prematurity
ActiveCN108392174AComprehensive detectionHigh precisionOthalmoscopesTreatment strategyRetinopathy of prematurity
The invention provides an auto-check method and system of retinopathy of prematurity, wherein the method comprises: acquiring a fundal image of a premature, and recognizing disease regions in the fundal image according to optic nerve heads, yellow spots and ora serrata in the fundal image; determining a disease stage corresponding to the fundal image according to disease characteristics in the disease regions; judging whether an additional disease is present in the fundal image according to disease characteristics present at the posterior pole in the fundal image; judging fundal disease type corresponding to the fundal image according to the disease stage and the judged additional disease, and providing a matching treatment strategy according to the fundal disease type. The auto-check method and system of retinopathy of prematurity enable retinopathy of prematurity to be detected highly precisely.
Owner:梁建宏 +2
Neoepitope detection of disease using protein arrays
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of determining efficacy of a pharmaceutical for treating a disease or staging disease by administering a pharmaceutical to a sample containing markers for a disease, detecting the amount of at least one marker of the disease in the sample, and analyzing the amount of the marker in the sample, whereby the amount of marker correlates to pharmaceutical efficacy or disease stage. Markers for gynecological disease. An immuno-imaging agent comprising labeled antibodies, whereby the labeled antibodies are isolated and reactive to proteins overexpressed in vivo. Informatics software for analyzing the arrays, the software including analyzing means for analyzing the arrays.
Owner:NAT INST OF HEALTH DIRECTOR DEITR
Methods and compositions for use in diagnosing and characterizing chronic immune disease
InactiveUS20050106631A1Bioreactor/fermenter combinationsBiological substance pretreatmentsDisease activityDisease progression
Methods are provided for diagnosing and / or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the presence of low molecular actin fragments. The assay results are used to diagnose the presence of chronic immune disease activity and / or characterize chronic immune disease activity in the subject, e.g. to confirm an initial chronic immune disease diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. Also provided by the subject invention are kits for practicing the methods.
Owner:PROTEA BIOPHARMA
Equine disease model for herpesvirus neurologic disease and uses thereof
InactiveUS20170281751A1Increase chanceProtection levelAntibacterial agentsViral antigen ingredientsNervous systemEquine herpesvirus
Owner:UNIV OF KENTUCKY RES FOUND
Novel medical usage of glutathione
PendingCN110115755AAvoid damageBlood sugar controlMetabolism disorderTripeptide ingredientsReactive oxygen species metabolismAcute hyperglycaemia
The invention provides application of glutathione in preparing a medicament for treating islet beta-cell damage caused by long-term fluctuating hyperglycemia and high-active oxygen metabolism memory.In addition, the invention also provides a pharmaceutical composition for treating the islet beta-cell damage caused by the high-active oxygen metabolism memory or fluctuating hyperglycemia, a pharmaceutical composition for preventing diabetes and a pharmaceutical composition for treating diabetic skin ulcer. The compositions contain the glutathione or a pharmaceutically acceptable salt derivativeof the glutathione. The drugs can be prepared into various dosage forms to cope with diseases of different types and different disease stages.
Owner:WENZHOU MEDICAL UNIV
Molecular marker relevant to non-small-cell lung cancer prognosis and application thereof
ActiveCN109735619AUniversal applicabilityMicrobiological testing/measurementDNA/RNA fragmentationData setIndividualized treatment
The invention provides a molecular marker relevant to non-small-cell lung cancer prognosis and application thereof. In combination with a non-small-cell lung caner gene chip expression data set, by means of a random forest law and Cox single-factor regression analysis, genes with expression levels remarkably relevant to the lifetime of patients are found in candidate genes, the genes are subjectedto survival analysis modeling through Cox multi-factor regression analysis, the expression of a model is evaluated through a Kaplan Meier method and a time-dependent ROC analysis method, a lung cancer prognosis marker set of 17 genes is obtained, the postoperative patients are subjected to lifetime length and recurrent risk degree classifying through specific gene combinations in the 17 genes respectively, and then individualized treatment is carried out. The molecular marker is not affected by the factors such as the NSCLC organization type, the disease stages, the ages and the genders, canbe used as an NSCLC prognosis evaluation tool, and has common adaptability for the NSCLC patients.
Owner:BEIJING INST OF GENOMICS CHINESE ACAD OF SCI CHINA NAT CENT FOR BIOINFORMATION
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