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Novel medical usage of glutathione

A glutathione and drug technology, applied in the field of medicine, can solve problems such as unclear action pathways

Pending Publication Date: 2019-08-13
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the role of GSH in scavenging ROS is still unclear

Method used

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  • Novel medical usage of glutathione
  • Novel medical usage of glutathione
  • Novel medical usage of glutathione

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Experimental program
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experiment example

[0024] Experimental Materials

[0025] Experimental animals: Adult female SD rats were selected for this subject, purchased from Shanghai Slack Co., Ltd., and raised in the animal room of the Institute of Heart Regenerative Medicine, School of Basic Medical Sciences, Wenzhou Medical University, for two weeks, and used for formal experiments after being adapted to the environment. The animal room is illuminated by natural day and night light, with 12 / 12 hours lighting / darkness treatment, well ventilated, eating and drinking freely, the ambient temperature is maintained at 23±2℃, and the relative humidity is maintained at 50-70%.

[0026] Main reagents and antibodies: Chloral hydrate was purchased from Sinopharm Chemical Reagent Co., Ltd., heparin sodium was purchased from Nanjing Audoforni Biotechnology Co., Ltd., Dextrose was purchased from Shanghai Yuanye Biotechnology Co., Ltd., and GSH was purchased from Shanghai Yuanye Biological Technology Co., Ltd. The list of antibodies use...

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Abstract

The invention provides application of glutathione in preparing a medicament for treating islet beta-cell damage caused by long-term fluctuating hyperglycemia and high-active oxygen metabolism memory.In addition, the invention also provides a pharmaceutical composition for treating the islet beta-cell damage caused by the high-active oxygen metabolism memory or fluctuating hyperglycemia, a pharmaceutical composition for preventing diabetes and a pharmaceutical composition for treating diabetic skin ulcer. The compositions contain the glutathione or a pharmaceutically acceptable salt derivativeof the glutathione. The drugs can be prepared into various dosage forms to cope with diseases of different types and different disease stages.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to the application of glutathione in the preparation of drugs for treating pancreatic islet β cell damage caused by long-term fluctuating hyperglycemia and high reactive oxygen metabolism memory. Background technique [0002] As of 2015, the number of diabetic patients in my country has reached 109.6 million, and about 1.3 million died of diabetes and its complications; in 2017, there were 451 million diabetic patients worldwide. Without intervention, the number of patients in my country will rise to 154 million by 2040, and the number of diabetic patients worldwide will increase to 693 million by 2045. Therefore, the prevention and treatment of diabetes cannot be delayed. Diabetes is mainly divided into type I diabetes and type II diabetes, both of which exhibit reduced or relatively reduced insulin secretion caused by functional defects of pancreatic β-cells. Therefore, protecting p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61P3/10
CPCA61K38/06A61P3/10
Inventor 李鸣张积太安慧倪凯笛
Owner WENZHOU MEDICAL UNIV
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