39 results about "Cell integrity" patented technology

Hibernating myocardium is characterized by viable myocardium with impaired function due to localized reduced perfusion. Hibernating myocytes retain cellular integrity, but cannot sustain high-energy requirements of contraction. High plasma levels of catecholamines, such as norepinepherine, are believed to be predictive of mortality from hibernating myocardium. Likewise, high levels of catecholamines lead to cardiomyopathy in patients with diabetes. GLP-1 reduces plasma norepinepherine levels, and it thus is useful in a method of treating hibernating myocardium or diabetic cardiomyopathy.

The technology disclosed relates to granular analysis of design data used to prepare chip designs for manufacturing and to identification of similarities and differences among parts of design data files. In particular, it relates to parsing data and organizing into canonical forms, digesting the canonical forms, and comparing digests of design data from different sources, such as designs and libraries of design templates. Organizing the design data into canonical forms generally reduces the sensitivity of data analysis to variations in data that have no functional impact on the design. The details of the granular analysis vary among design languages used to represent aspects of a design. For various design languages, granular analysis includes partitioning design files by header / cell portions, by separate handling of comments, by functionally significant / non-significant data, by whitespace / non-whitespace, and by layer within a unit of design data. The similarities and differences of interest depend on the purpose of the granular analysis. The comparisons are useful in many ways.

This invention is directed to methods of preventing or treating diseases or conditions associated with alterations in cellular integrity including alterations in endothelial permeability, excessive cell proliferation or tissue remodeling. Particularly, this invention is directed to methods of treating diabetic nephropathy, malaria, or cancer. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel rho kinase inhibitor compound to treat the disease.

The invention discloses a cell freezing solution for preparing a dry tumor cell quality control and application of the cell freezing solution. According to a formula, the cell freezing solution is prepared by adding 5-25% of protein, 3-15% of a cell stabilizing agent A, 1-10% of a cell stabilizing agent B and 0.01-0.1% of a bacteriostatic agent into PBS (phosphate buffer solution). The cell freezing solution successfully solves the problems that a cell integrity rate after freeze-drying is very low or active ingredients of cell membrane structural proteins and cell contents cannot be reservedwell in the existing cell freeze-drying technology. A preparation method of the dry tumor cell quality control directly uses human-derived tumor cell strains containing cell membrane structures and contents to prepare the quality control; the quality control is derived from human tumor cells and has the same characteristics as those of similar tumor cells in clinical liquid biopsy detection samples; and the quality control prepared by the method is applicable to the quality control of clinical liquid biopsy and can promote extensive popularization and application of the clinical liquid biopsy.

The technology disclosed relates to granular analysis of design data used to prepare chip designs for manufacturing and to identification of similarities and differences among parts of design data files. In particular, it relates to parsing data and organizing into canonical forms, digesting the canonical forms, and comparing digests of design data from different sources, such as designs and libraries of design templates. Organizing the design data into canonical forms generally reduces the sensitivity of data analysis to variations in data that have no functional impact on the design. The details of the granular analysis vary among design languages used to represent aspects of a design. For various design languages, granular analysis includes partitioning design files by header / cell portions, by separate handling of comments, by functionally significant / non-significant data, by whitespace / non-whitespace, and by layer within a unit of design data. The similarities and differences of interest depend on the purpose of the granular analysis. The comparisons are useful in many ways.

The invention discloses a non-water leucorrhea specimen storing liquid and a preparation method and pH value test collection tube of the liquid. The non-water leucorrhea specimen storing liquid comprises the following substances by weight percent: 96.5wt% of anhydrous glycerin, 0.2wt% of polyethyleneglycol 8000 as a surface active agent, 0.25wt% of bromocresol green, 0.05wt% of methyl red, 2.0wt% of absolute ethyl alcohol and 1.0wt% of mercapto sodium acetate. The non-water leucorrhea specimen storing liquid has the advantages that visible components such as bacteriums, cells, trichomonads and sick bodies of the leucorrhea can be protected by anhydrous glycerin (glycerol) when being frozen at a temperature less than -20 DEG C; the cell completeness of the visible components such as cells, bacteriums, trichomonads and the like can still be maintained after being redissolved without changing the morphology under a microscope; the leucorrhea can be solved in water in any concentration when needing to be diluted; mercapto sodium acetate is used as a reducing agent to prevent the specimen from inactivation caused by dehydration, oxidation and autolysis during the storage or transportation; and the non-water leucorrhea specimen storing liquid does not affect the cell lysis and determination of Chlamydia trachomatis or various causative agents of the leucorrhea.