80 results about "Cancer Radiotherapy" patented technology

The invention relates to a natural pharmaceutical composition, a preparation method thereof and an application of the natural pharmaceutical composition in preparation of attenuated synergistic medicaments in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition is prepared from extract obtained by decocting and concentrating ginger and dried orange peel decoction, gingerol, dried orange peel water extract and nobiletin according to the ratios of (3-5):(2-9):(1-6):(2-5). The composition has an excellent effect on treating emesis and other side effects caused by cancer radiotherapy and chemotherapy, and can simultaneously play a role in inhibiting tumors.

The invention relates to a preparation method of chronic wound dressing, and in particular, relates to a medical dressing loaded with nano silver and bioactive factors and a preparation method thereof. The dressing includes calcium alginate, chitosan or a chitosan derivative as a matrix and is loaded with nano silver antibacterial composition particles and a growth factor EGF. During preparation,calcium alginate core microspheres wrapped with the growth factor are obtained by dropwise adding a sodium alginate solution mixed with the growth factor into a calcium chloride solution. The microspheres are added to a chitosan acetic acid solution to form a polyelectrolyte complex. Then the polyelectrolyte complex is mixed and stirred with nano silver and chitosan, the mixture is added to sodiumalginate, crosslinking and freeze-drying are performed, and finally, the chronic wound dressing loaded with nano silver and the growth factor is formed. The raw materials of the method are cheap andeasy to obtain, the preparation process is stable, the bacteriostatic performance of the chronic wound dressing is good, and the wound repair ability is excellent. The dressing is used for treating various chronic wounds caused by cancer radiotherapy, diabetes, ischemia and the like, and induces cleaning and repairing of the wounds.

The invention relates to a dendrobium officinale health-care product. Contents of a dry product formula of the product can be represented by a weight ratio that dendrobium officinale to American ginseng to notoginseng to cistanche tubulosa to cordyceps sinensis is 1:0.4-0.6:0.4-0.6:0.6-0.8:0.2-0.4. The health-care product provided by the invention has the advantages that, raw material compositions of the product provide relatively comprehensive healing and health-caring functions upon human bodies. The functions are comprehensive, and can be delivered in meridians of heat, lung, stomach, kidney, liver, and large intestine. The product provides functions of internal organ tonifying, tranquilizing and nerve soothing, blood tonifying, essence solidifying, bone health promoting, yin and yang balancing, and immunity enhancing. Raw materials adopted by the invention provide complementary synergetic effects. With the appropriate components, the performance of the product is mild. Effects of all the materials can be developed sufficiently, conflicting and adverse reactions are avoided, and synergetic effects are provided. An optimal effect can be achieved with a minimal dosage. The product provided by the invention can substantially ameliorate a sub-healthy state, and has substantial effects in nursing after serious illness, chronic disease, and operation, in eliminating cancer radiotherapy and chemotherapy adverse reactions, and in recovering physical strength.

The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition and the use of the natural pharmaceutical composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition consists of decocted and concentrated extract of ginger and clove, gingerol, clove ethanol extract and eugenol based on the proportion of 3 to 6: 2 to 5: 3 to 5: 2 to 9, and the composition has extremely good therapeutic effect for vomiting and other side effects caused by cancer radiotherapy and chemotherapy and can simultaneously play the role of inhibiting tumor.

The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition and the use of the natural pharmaceutical composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition consists of decocted and concentrated extract of ginger and elecampane, gingerol, elecampane chloroform extract and elecampane hexane extract based on the proportion of 4 to 8: 3 to 8: 4 to 5: 2 to 4, and the composition has extremely good therapeutic effect for vomiting and other side effects caused by cancer radiotherapy and chemotherapy and can simultaneously play the role of inhibiting tumor.

The invention belongs to the medicine, processing and healthcare food technical field of cordyceps sinensis, particularly relating to a preparation method of the cordyceps sinensis extractive concentrated solution got by hirsrtella sinensis or hirsutella hepialid and applications of the cordyceps sinensis extractive concentrated solution in preparation of various preparation forms of medicine or healthcare products for strengthening and regulating immunity; thereby the solution can be applied for treating deficiency in lung and kidney, cancers and for helping strengthening immunity after themotherapy. The preparation of the invention is that the hirsrtella sinensis is fermented to produce cordyceps sinensis which is extracted respectively by ethanol, water and zymohydrolysis and then the extractive is condensed into concentrated solution which is produced into various preparation forms by spray-drying or directly produced into soft capsules after sterilization, and then the finished product is prepared well after packing and inspecting. No additive is added into the finished product which is composed of the extractive concentrated solution by 100 per cent. The various preparations prepared by the extractive concentrated solution of cordyceps sinensis all have multiple functions of restoring the deficiency in lung and kidney, strengthening immunity and enhancing resistance and have the function of regulating and steadying the immunological system of a human body, not only applicable to sub-healthy people for regular health care but also evident in efficacy for people who takes organ transplantation, cancer radiotherapy and chemotherapy, pneumonia, hepatitis, chronic nephritis and valetudinarianism.

A method for evaluation of cancer diagnosis following cancer radiotherapy, comprising: providing a serum sample of a cancer patient prior to the cancer radiotherapy; and measuring a leukemia inhibitory factor concentration in the serum sample. Also provided is a method for potentiation of cancer radiotherapy, comprising: administrating a leukemia inhibitory factor inhibitor or a leukemia inhibitory factor receptor inhibitor to a subject in need of the cancer radiotherapy.

The invention relates to a preparation of traditional Chinese medicine decoction pieces, and particularly relates to a leukocyte-increasing traditional Chinese medicine decoction piece combined preparation as well as a preparation method and a combined package thereof. The preparation is prepared from the following raw materials in parts by weight: 10-15 parts of epimedium, 10-15 parts of fructus psoraleae, 5-10 parts of radix aconiti carmichaeli, 5-10 parts of fructus lycii, 5-10 parts of astragalus membranaceus, 3-8 parts of suberect spatholobus stem, 3-5 parts of rubia cordifolia, 3-5 parts of angelica sinensis, 1-3 parts of rhizoma phragmitis, 1-3 parts of radix ophiopogonis and 1-3 parts of licorice root. The preparation has the effects of warming kidneys and strengthening spleen, tonifying qi and blood, is used for treating patients with leukocytopenia due to spleen-kidney yang deficiency and qi-blood deficiency caused by cancer radiotherapy and chemotherapy, wherein leukocytopenia due to spleen-kidney yang deficiency and qi-blood deficiency has the syndromes of exhaust and fatigue, lack of energy, extreme chilliness, poor appetite and loose stool, soreness and weakness of waist and knees and the like. The preparation is capable of effectively increasing the content of leukocyte in blood, reducing the toxic and side effect of chemotherapy, and effectively improving the living quality of tumor patients.

The invention provides a medicinal composition containing a neurokinin 1(NK-1) receptor antagonist, a 5-hydroxytryptamine 3 (5HT-3) receptor antagonist and adrenocortical hormone. The medicinal composition adopts a NK-1 receptor antagonist, a 5HT-3 receptor antagonist and adrenocortical hormone as active components, is added with certain auxiliaries with specific spices and proportion to prepare and develop an oral preparation according to a technical means specified in the invention. The medicinal composition can be used for preventing and treating nausea and emesis caused by cancer radiotherapy, chemotherapy and operation. The invention aims to provide a medicinal composition preparation which can prevent and treat emesis more conveniently by utilizing the NK-1 receptor antagonist, the 5HT-3 receptor antagonist and adrenocortical hormone, thereby improving the compliance of a patient.

A method for evaluation of cancer diagnosis following cancer radiotherapy, comprising: providing a serum sample of a cancer patient prior to the cancer radiotherapy; and measuring a leukemia inhibitory factor concentration in the serum sample. Also provided is a method for potentiation of cancer radiotherapy, comprising: administrating a leukemia inhibitory factor inhibitor or a leukemia inhibitory factor receptor inhibitor to a subject in need of the cancer radiotherapy.

The invention discloses a nutritional herbal cuisine based on a cancer radiotherapy patient. The nutritional herbal cuisine is prepared from the following main raw materials in parts by weight: 3-7 parts of walnut powder, 5-15 parts of rhizome of kirilow rhodiola, 3-8 parts of black sesames, 2-6 parts of hericium erinaceus, 1-5 parts of centella, 10-20 parts of radix angelicae pubescentis, 5-15 parts of Chinese yams, 6-13 parts of corns, 7-14 parts of soybeans, 100-200 parts of pork trotters, 7-15 parts of astragalus membranaceus, 10-20 parts of green onions, 4-10 parts of pearl barley, 2-6 parts of polygonum multiflorum, 3-6 parts of astaxanthin and 2-7 parts of garlic essence. The nutritional herbal cuisine is prepared based on a Chinese medicine symptom distinguishing treatment principle. The treatment is more comprehensive; the absorption is rapid and the pharmacological effect is lasting; and the nutritional herbal cuisine based on the cancer radiotherapy patient has an extremely good conditioning effect on weak bodies caused by long-time chemoradiotherapy.

The invention provides a rectal cancer radiotherapy plan automatic design method based on deep learning. The method comprises the steps: establishing a U-Net neural network used for deep learning, andestablishing a case database, wherein the case database is clinical intensity modulated radiotherapy plan data of rectal cancer; performing deep learning on the case database to train the U-Net neural network; transmitting a img file of the CT positioning data to the trained U-Net neural network to obtain a prediction target area and prediction dose distribution output by the U-Net neural network; obtaining a dose objective function according to the prediction target area and the prediction dose distribution; and designing a radiotherapy plan by using a Pinnacle planning system according to the prediction target area and the dose objective function. Therefore, the rectal cancer radiotherapy plan automatic design method based on deep learning integrates the target area sketching technology, the dose prediction technology and the automatic planning technology, and the full-automatic design process of the individualized radiotherapy plan is realized in combination with the Pinnacle plansystem.

The present invention relates to a method of treatment and / or prophylaxis of a microbial infection, comprising the step of administering an effective amount of a compound of formula (I), in which X and Y are either the same or different and selected from a heteroatom; is a double or single bond depending on the heteroatoms X and Y; R1 to R5 are either the same or different and selected from hydrogen or a non-deleterious substituent; and R6 and R7 are either the same or different and selected from hydrogen and a non-deleterious substituent or one of R6 and R7 are absent when there is a double bond present, pharmaceutically acceptable salts or derivatives, pro-drugs, tautomers and / or isomers thereof. The present invention also relates to a method for protecting a subject from radiation damage, a method of cancer radiotherapy and use as an antimicrobial or radioprotective agent of the compound of formula (I) defined above. Some of the compounds of formula (I) are novel and are also described in the present invention, together with pharmaceutical or veterinary compositions containing them.

The invention relates to a natural pharmaceutical composition, a preparation method of the natural pharmaceutical composition and the use of the natural pharmaceutical composition for preparing toxicity-reducing efficacy-improving medicine in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition consists of decocted and concentrated extract of ginger and clove, gingerol, clove ethanol extract and eugenol based on the proportion of 3 to 6: 2 to 5: 3 to 5: 2 to 9, and the composition has extremely good therapeutic effect for vomiting and other side effects caused by cancer radiotherapy and chemotherapy and can simultaneously play the role of inhibiting tumor.

A construction method of a cell model is disclosed, by which a rectal cancer radiotherapy resistant cell strain is obtained in a manner of gradiently increasing radiation dose of X-ray, wherein the cell strain is sourced from an SW480 cell and the resistance of the resistant cell under high radiation dose and low radiation dose are both higher than those of the parent SW480 cell strain.

The invention discloses spirulina breakfast bread. The spirulina breakfast bread consists of the following raw materials in parts by weight: 900-1100 parts of strong flour, 180-220 parts of sugar, 70-90 parts of butter, 70-90 parts of eggs, 550-570 parts of water, 10-20 parts of yeast, 10-20 parts of salt, 2-4 parts of a bread modifier, and 30-200 parts of spirulina. The invention further discloses a making method of the spirulina breakfast bread. The prepared bread disclosed by the invention is loose, fragrant and sweet, is chewy when being put in the mouth, and besides, has the efficacies of alleviating toxin and side effects of cancer radiotherapy and chemotherapy, improving immunity, and reducing blood lipid.

The invention discloses a method for assessing a cancer radiotherapy and chemotherapy standard conforming degree. The method includes the following steps: firstly, defining an assessment model of the cancer radiotherapy and chemotherapy standard conforming degree, secondly, formulating executing rules of difference assessment of radiotherapy and chemotherapy operation standards and difference assessment of chemotherapy drug use and radiation dosage use, enabling an assessor to respectively assess whether radiotherapy and chemotherapy processes of a certain patient conform to the radiotherapy and chemotherapy operation standards and chemotherapy drug use and radiation dosage standards or not, then, formulating a multi-level itemizing weighting rule so as to grade a total standard conforming degree of the radiotherapy and chemotherapy processes of the cancer patient, finally, taking corresponding measures on patient diagnosis and treatment based on the score, enabling a therapeutic schedule with the score lower than a veto threshold value and drug use with the score lower than a veto threshold value to be refused, and enabling a therapeutic schedule with the score higher than a standard-conforming threshold value and drug use with the score higher than a standard-conforming threshold value to be accurately submitted and applied. According to the method for assessing the cancer radiotherapy and chemotherapy standard conforming degree, the appearing probability of non-standard operations and non-standard drug use in the cancer radiotherapy and chemotherapy processes can be reduced.

The invention provides a medicament for promoting a hematopoietic function after radiotherapy. The medicament is prepared from the following medicaments: 20g of astragalus, 15g of pilose asiabell root, 15g of Chinese wolfberry, 10g of American ginseng, 15g of dwarf lilyturf tuber, 12g of Indian buead, 8g of Chinese magnoliavine fruit, 12g of largehead atractylodes rhizome, 12g of officinal magnolia bark, 7g of Chinese angelica, 8g of tangerine peel, 8g of tuber fleeceflower root, 8g of giant knotweed rhizome, 7g of eucommia bark, 8g of yerbadetajo herb, 8g of baked ginger and 4g of liquoric root. The medicament provided by the invention has a significant promotion effect on the hematopoietic function of cancer patients after radiotherapy.

The invention provides a use of CX4945 for preparation of a drug having a reversal effect on gastric cancer cisplatin-resistant radiation tolerance, is used in preparation of the gastric cancer cisplatin-resistant radiation tolerance reversal drug, and provides the CX4945 as a gastric cancer cisplatin-resistant radiation tolerance reversal agent applied in clinic; the CX4945 can overcome the gastric cancer cisplatin-resistant cell radiation tolerance, enhances radiosensitivity, reduces the radiotherapy killing dose, alleviates the response of radiotherapy, improves the curative effect of gastric cancer radiotherapy, and provides a better method for treatment of gastric cancer.

The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. A radiotherapy enhancer comprising (A) tegafur and (B) gimeracil.

The invention relates to an isoquinoline drug, and its preparation method and application. The molecular formula of the drug is C37H40N2O6.2HCl.nH2O, wherein n is 3 or 3.5. With good storage stability, the isoquinoline drug is suitable for application in preparation of medicines promoting proliferation of white blood cells, preventing white blood cell decrease after cancer radiotherapy and chemotherapy, resisting inflammation, resisting tuberculosis, resisting silicosis, resisting tumor, reducing blood pressure, resisting myocardial anoxia and ischemia, resisting arrhythmia, and treating or preventing other diseases.

The invention provides a production method of tissue compensation glue for cancer radiotherapy, the preparation method comprises the following steps: 1, weighing solid paraffin, low-density polyethylene, a styrene-maleic anhydride copolymer and cross-linked povidone according to the mass ratio of 100: 2: 12-14: 3-7; S2, mixing the styrene-maleic anhydride copolymer with the cross-linked povidone,adding 1,4-dioxane for co-boiling, then cooling to 10-20 DEG C, keeping for 30-40 minutes, then adding hydroxylamine hydrochloride and sodium methoxide to react, then adding methylbenzene for co-boiling for 5 hours, filtering, washing filter residue with diethyl ether and water, and carrying out vacuum drying on the filter residue until the filter residue reaches constant weight to obtain a synergist; S3, mixing and injecting the solid paraffin, the low-density polyethylene and the synergist into a mold, and performing molding and demolding to obtain the tissue compensation adhesive for cancerradiotherapy. The production method provided by the invention has the advantages of simple operation and one-time forming, and the produced tissue compensation glue can be applied to cancer radiotherapy and is good in adhesion to skin.

A nutritional supplement containing fish oil and selenium has been identified that potentiates radiotherapy of tumors in a synergistic fashion. Cotherapy with such a supplement and radiotherapy results in substantially improved reductions in tumor volume of animal models relative to radiotherapy alone, and reduces common side effects such as weight loss, inflammation, and damage to the gastrointestinal tract. Such cotherapy was also found to reduce the incidence of metastasis from the primary implantation site, and to modulate expression of genes associated with apoptosis in tumor cells. A formulation for such a supplement that is both well tolerated and palatable is also provided.

A nutritional supplement is described that enhances and provides synergistic effects when used in combination with radiotherapy to treat tumors, both reducing tumor size and preventing metastasis. The nutritional supplement has been also found to be effective in reducing negative side effects of concurrent radiotherapy, including inflammation, weight loss, muscle wasting, neutropenia, and loss of cells from the lining of the gut.

The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. There is provided a radiotherapy enhancer comprising, as an active ingredient, a pyridine derivative represented by general formula (1):wherein R1, R2, and R4 may be the same or different from one another and represent a hydrogen atom, hydroxy group, or protected hydroxy group, excluding the case where R1, R2, and R4 are all a hydrogen atom, and R3 represents a halogen atom, amino group, carboxyl group, carbamoyl group, cyano group, nitro group, alkyl group having 1 to 6 carbon atoms, alkenyl group having 2 to 6 carbon atoms, or carbonyl group containing an alkoxy group having 1 to 6 carbon atoms).

The invention relates to radioprotectors of formula (I), processes for their preparation and their use in protecting biological materials from radiation damage. In diagnostic and therapeutic radiology, particularly in cancer radiotherapy, the radioprotectors of the present invention may be used to protect certain normal tissues or structures from radiation damage. The radioprotectors of formula (I) may also have uses in decreasing the effects of irradiation in non-medical scenarios, both civil and military.

The invention discloses tissue equivalent filler for cancer radiotherapy. Liquid paraffin and ethylene-butadiene-styrene block copolymer are mixed into mixture; the mixture is heated and cured to obtain the tissue equivalent filler. The ethylene-butadiene-styrene block copolymer in the mixture is 3-20% in mass fraction. The tissue equivalent filler can fitly attach to the body of a patient, and no bubble forms between the filler and the body of the patient; the tissue equivalent filler is good in transparency and allows doctors to see a mark on the body of the patient through the filler, so that radiation dosage is more accurate and more uniform.

The invention relates to a traditional Chinese medicine composition cooperating for radiotherapy of cancers. The traditional Chinese medicine composition comprises, by weight, 3-8 parts of persimmon leaf, 2-7 parts of sea-tangle, 2-5 parts of fruit of Rosa dahurica, 2-5 parts of wild groundnut seed, 3-8 parts of Angelica vine, 5-10 parts of Limonium sinense root or herb, 5-15 parts of mulberry, 3-18 parts of black soybean seed coat, 2-4 parts of all-grass of Swertia heterantha, 2-5 parts of fruit of densehead Mountainash, 5-8 parts of dried scallop, 3-5 parts of Wilson Begonia rhizome, and 2-6 parts of tuber of Dioscorea pentaphylla. With the herbs being compatible, the traditional Chinese medicine composition has the effects of reinforcing and enriching vital essence, tonifying spleen to replenish blood, nourishing blood and yin and tonifying spleen and kidney, is capable of adjusting physical physiological function, improving immunity, effectively releasing symptoms caused by cancer radiotherapy, such as lower leukocyte level, weakness and alopecia and improving survival quality of a patient.

The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. A radiotherapy enhancer comprising (A) tegafur and (B) gimeracil.

The invention relates to a natural pharmaceutical composition, a preparation method thereof and an application of the natural pharmaceutical composition in preparation of attenuated synergistic medicaments in cancer radiotherapy and chemotherapy. The natural pharmaceutical composition is prepared from extract obtained by concentrating tuber pinellia and dried ginger powder, gingerol, tuber pinellia alkaloid and tuber pinellia polysaccharide according to the ratios of (3-8):(2-6):(1-5):(2-7). The composition has an excellent effect on treating emesis and other side effects caused by cancer radiotherapy and chemotherapy, and can simultaneously play a role in inhibiting tumors.