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Use of CX4945 for preparation of drug having reversal effect on gastric cancer cisplatin-resistant radiation tolerance

A radiotolerance and drug technology, applied in the field of medicine and pharmacy, to achieve the effect of overcoming radiotolerance, enhancing radiosensitivity, and improving curative effect

Inactive Publication Date: 2016-05-11
耿炜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether CX-4945 has a radiosensitizing effect has not been reported in the literature

Method used

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  • Use of CX4945 for preparation of drug having reversal effect on gastric cancer cisplatin-resistant radiation tolerance
  • Use of CX4945 for preparation of drug having reversal effect on gastric cancer cisplatin-resistant radiation tolerance
  • Use of CX4945 for preparation of drug having reversal effect on gastric cancer cisplatin-resistant radiation tolerance

Examples

Experimental program
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Embodiment Construction

[0037] The following further describes the present invention in detail with reference to the accompanying drawings and specific embodiments, which is an explanation rather than a limitation of the present invention.

[0038] The CX4945 used in the following examples was purchased from Selleck, and the radiotherapy equipment was a Varian 2300 linear accelerator.

[0039] The following examples further illustrate the present invention through cell biology and molecular biology experiments on the radiotolerance reversal effect of CX4945 on gastric cancer drug-resistant cells, but it does not mean that the present invention is limited to this example

[0040] CX4945 is added with pharmaceutically acceptable excipients to prepare various dosage forms according to conventional methods, such as liquid injections of various specifications, powder injections, emulsions for injection, tablets, pills, capsules, ointments, creams, patches, rubs Agents, powders, sprays, implants, drops, supposito...

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Abstract

The invention provides a use of CX4945 for preparation of a drug having a reversal effect on gastric cancer cisplatin-resistant radiation tolerance, is used in preparation of the gastric cancer cisplatin-resistant radiation tolerance reversal drug, and provides the CX4945 as a gastric cancer cisplatin-resistant radiation tolerance reversal agent applied in clinic; the CX4945 can overcome the gastric cancer cisplatin-resistant cell radiation tolerance, enhances radiosensitivity, reduces the radiotherapy killing dose, alleviates the response of radiotherapy, improves the curative effect of gastric cancer radiotherapy, and provides a better method for treatment of gastric cancer.

Description

Technical field [0001] The invention provides the use of CX4945 as a medicine for the preparation of gastric cancer cisplatin-resistant radiotolerance reversal drugs, which is used to prepare gastric cancer cisplatin-resistant radiotolerance reversal drugs, and belongs to the technical field of medical pharmacy. Background technique [0002] Gastric cancer is the third malignant tumor in my country with both morbidity and mortality. According to statistics from the World Health Organization, in 2012, there were 400,000 gastric cancer cases and 320,000 deaths in my country. The five-year survival rate of gastric cancer patients was less than 20%. Surgery, chemotherapy, and radiotherapy are the main treatments for gastric cancer. Early gastric cancer can be surgically removed local tumor lesions, advanced gastric cancer due to extensive infiltration and metastasis, lose the opportunity for surgery, the combination of radiotherapy and chemotherapy is the main treatment plan. The t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4745A61P35/00
CPCA61K31/4745
Inventor 耿炜许文侠曹海英周建伟吴锦昌
Owner 耿炜
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