Application of cx4945 as a medicine for reversing cisplatin-resistant radiation tolerance in gastric cancer

A technology of CX4945 and radiation tolerance, which is applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., to reduce the effect of radiotherapy response, improve curative effect, and reduce the killing dose of radiotherapy

Inactive Publication Date: 2019-02-15
耿炜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, whether CX-4945 has a radiosensitizing effect has not been reported in the literature

Method used

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  • Application of cx4945 as a medicine for reversing cisplatin-resistant radiation tolerance in gastric cancer
  • Application of cx4945 as a medicine for reversing cisplatin-resistant radiation tolerance in gastric cancer
  • Application of cx4945 as a medicine for reversing cisplatin-resistant radiation tolerance in gastric cancer

Examples

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Embodiment Construction

[0038] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments, which are explanations rather than limitations of the present invention.

[0039] The CX4945 used in the following examples was purchased from Selleck, and the radiotherapy equipment was a Varian 2300 linear accelerator.

[0040] The following examples further illustrate the present invention through cell biology and molecular biology experiments of CX4945 on the reversal of radiation tolerance of gastric cancer drug-resistant cells, but it does not mean that the present invention is limited to this example

[0041] CX4945 is made into various dosage forms by adding pharmaceutically acceptable excipients according to conventional methods, such as liquid injections of various specifications, powder injections, emulsions for injections, tablets, pills, capsules, ointments, creams, patches, wipes, etc. Elixir, powder, spray, implant, drop,...

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Abstract

The invention provides a use of CX4945 for preparation of a drug having a reversal effect on gastric cancer cisplatin-resistant radiation tolerance, is used in preparation of the gastric cancer cisplatin-resistant radiation tolerance reversal drug, and provides the CX4945 as a gastric cancer cisplatin-resistant radiation tolerance reversal agent applied in clinic; the CX4945 can overcome the gastric cancer cisplatin-resistant cell radiation tolerance, enhances radiosensitivity, reduces the radiotherapy killing dose, alleviates the response of radiotherapy, improves the curative effect of gastric cancer radiotherapy, and provides a better method for treatment of gastric cancer.

Description

technical field [0001] The invention provides the use of CX4945 as a medicine for reversing cisplatin-resistant radiotolerance of gastric cancer, which is used for preparing the medicine for reversing cisplatin-resistant radiotolerance of gastric cancer, and belongs to the technical field of medical pharmacy. Background technique [0002] Gastric cancer is a malignant tumor with the third highest morbidity and mortality in my country. According to the statistics of the World Health Organization, in 2012, the incidence of gastric cancer in my country was 400,000, and the death toll was 320,000. The five-year survival rate of gastric cancer patients was less than 20%. Surgery, chemotherapy, and radiotherapy are the main methods for treating gastric cancer. Early gastric cancer can be surgically resected with local tumor lesions, while advanced gastric cancer loses the opportunity for surgery due to extensive invasion and metastasis, and combined radiotherapy and chemotherapy ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4745A61P35/00
CPCA61K31/4745
Inventor 耿炜许文侠曹海英周建伟吴锦昌
Owner 耿炜
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