61 results about "Blood creatinine" patented technology

PCT No. PCT / JP96 / 01225 Sec. 371 Date Mar. 27, 1998 Sec. 102(e) Date Mar. 27, 1998 PCT Filed May 9, 1996 PCT Pub. No. WO97 / 12631 PCT Pub. Date Apr. 10, 1997Drug which contains human growth hormones capable of recovering the renal function when administered to a patient who has renal insufficiency but has not yet undergone kidney dialysis. By administrating the drug, the loss of renal function represented by an extreme decrease in creatinine clearance or the reciprocal of blood creatinine level can be prevented and thus it can dispense with the dialytic treatment for patients with renal insufficiency.

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method. The traditional Chinese medicine composition is prepared from the following raw material medicines by weight: 6-40 parts of rheum officinale, 10-95 parts of astragalus and 5-65 parts of salvia miltiorrhiza by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum creatinine and urea nitrogen and other indexes of rats subjected to hypertensive nephropathy, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to the chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; and pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure.

The invention discloses an application of physically-modified Chinese cobra venom in preparation of medicaments for treating acute and chronic nephrosis. The physically-modified Chinese cobra venom is obtained by dissolving Chinese cobra venom with deionized water, heating for denaturation and then performing renaturation; the heating temperature is controlled to be 50-100 DEG C, and the heating time is controlled to be 1 min-300 min. The invention finds that the heated and denaturated Chinese cobra venom can effectively reduce urine protein in acute and chronic nephrosis, reduce serum creatinine, and urea nitrogen, improve the pathological damage degree of the kidney, and recover kidney functions.

The invention provides a traditional Chinese medicine composition for treating chronic kidney diseases and chronic renal failure. The traditional Chinese medicine composition is prepared from radix et rhizoma rhei preparata, Chinese peashrub roots, herba centellae, rhizoma curcumae, radix salviae miltiorrhizae, rhizoma smilacis glabrae, flos carthami, rhizoma polygoni cuspidati, herba pyrolae, lucid ganoderma, radix astragali and fructus aurantii. The radix et rhizoma rhei preparata has the effects of promoting blood circulation, detoxifying and eliminating turbidity, the Chinese peashrub roots has the effects of dispelling wind, detoxifying and reducring urinary protein, the herba centellae has the effects of dispelling wind, detoxifying and reducing creatinine, the rhizoma curcumae has the effects of breaking blood, promoting qi and resisting fibrosis, the radix salviae miltiorrhizae and the flos carthami have the effects of promoting blood circulation and removing blood stasis, the rhizoma smilacis glabrae has the effects of clearing heat, detoxifying and drying dampness, the rhizoma polygoni cuspidati has the effects of dispelling wind, detoxifying and reducing uric acid, the herba pyrolae has the effects of tonifying kidney and clearing away dieresis, the lucid ganoderma and the radix astragali have the effects of invigorating qi and strengthening health, and the fructus aurantii has the effects of soothing liver and regulating qi. The traditional Chinese medicine composition can effectively reduce proteinuria and hematuria of patients with chronic kidney diseases, relieve renal function progression of chronic renal failure, reduce serum creatinine, improve clinical symptoms of patients with chronic kidney diseases, especially chronic renal failure, and protect renal functions.

The invention discloses a sharpleaf galangal fruit extract capable of treating chronic kidney diseases. The extract is prepared by the following steps: grinding sharpleaf galangal fruits to remove the shells, adding a certain amount of ethanol, carrying out reflux extraction, collecting the extract, making the extract go through macroporous resin, eluting the macroporous resin by low-concentration ethanol to remove the impurities, then eluting the macroporous resin by high-concentration ethanol, condensing to obtain extract, separating the extract in a silica gel column, and carrying out crystallization so as to obtain the sharpleaf galangal fruit extract. According to the pathogenesis of chronic kidney diseases and on the basis of traditional Chinese medicine theory, the inventor researches the chemical components and the clinical curative effect of sharpleaf galangal fruit. The results of a great number of experiments show that the prepared sharpleaf galangal fruit extract (nootkatone) can prominently reduce proteinuria, can also obviously reduce the levels of serum creatinine and urea nitrogen, has a good kidney protective effect, and can be used to prevent and treat chronic kidney diseases.

The invention relates to new application and a new action mechanism of verbascoside, in particular to application of verbascoside in the drugs for treating and preventing type II diabetic nephropathy,and the research on the protection function of the verbascoside for the type II diabetic nephropathy and the action mechanism thereof. Results show that the verbascoside can alleviate liver injury caused by high glucose and lower the serum creatinine, urea nitrogen and urinary microalbuminuria levels, the blood fat level (total cholesterol and triglyceride) and the fasting blood-glucose and bloodinsulin level of spontaneous diabetes db / db mice; TGF (Transforming Growth Factor)-beta 1 and the signal transduction protein Smad3 and Smad4 and alpha-SMA protein expression thereof in a kidney tissue are obviously lowered; meanwhile, the verbascoside can alleviate the liver injury caused by high glucose; HK-2 proliferation and EMT (pithelial-Mesenchymal Transition) formation can be inhibited. In conclusion, the verbascoside has an obvious protection function on the type II diabetic nephropathy, the action mechanism of the verbascoside is that the kidney protection function of the verbascoside is implemented through oxidative stress reaction regulation and control, TGF-beta / smad signaling channel inhibition and kidney fibrosis alleviation.

The invention relates to the field of renal fibrosis disease treatment medicaments, in particular to an application of a hydrogen sulfide releasing agent in preparation of a medicament for treating renal fibrosis disease. According to the application of the hydrogen sulfide releasing agent in the preparation of the medicament for treating the renal fibrosis disease, the hydrogen sulfide releasing agent is sodium hydrosulfide or sodium sulfide. The sodium hydrosulfide or the sodium sulfide acts on renal fibroblasts, so that proliferation and differentiation of the renal interstitial fibroblasts are inhibited, deposition of renal interstitial collagen fibers is inhibited, the renal function is improved, further rise of serum creatinine and serum potassium levels is avoided, and the releasing agent has an effect of resisting renal fibrosis.

The invention relates to a traditional Chinese medicine preparation for treating diabetic nephropathy and preparation and administration methods thereof. The traditional Chinese medicine preparation is prepared from the following raw materials: astragalus membranaceus, radix pseudostellariae, semen cuscutae, cornus officinalis sieb et zucc, bighead atractylodes rhizome, the root of kudzu vine, gorgon fruit powder, fructus rosae laevigatae powder, periostracum cicada powder, eupatorium powder, agastache rugosus powder, rheum officinale powder, scutellaria baicalensis powder, radix rehmanniae recen, pseudo-ginseng powder and salviae miltiorrhizae. According to the theory of traditional Chinese medicine, treatment determination based on syndrome differentiation is performed by combining features of incidence of diabetic nephropathy and the condition of kidney injury, so that a traditional Chinese medicine compound preparation is formulated; through long-term clinical observation, the clinical symptoms of a patient are improved, proteinuria, urea nitrogen and serum creatinine are decreased to different extents, development of nephropathy is delayed, the renal function is improved, and the preparation plays a role of treating both symptoms and root causes.

The invention relates to application of fisetin in preparation of a medicine for preventing and treating uric acid nephropathy, and belongs to the field of medicine. The invention provides application of fisetin or salt thereof in preparation of the medicine for treating and / or preventing the uric acid nephropathy. Animal experiments prove that the fisetin can regulate protein expression of kidney urate transporters URAT1, OAT1, OAT3 and ABCG2, improve uric acid excretion rate and obviously reduce serum creatinine, blood urea nitrogen and blood uric acid levels, also has an effect of inhibiting renal interstitial fibrosis, can obviously reduce expression quantities of fibrosis-related proteins such as alpha-SMA, cologen I and fibronectin, has an exact prevention / treatment effect on the uric acid nephropathy and provides a new choice for clinical medication.

The invention provides a traditional Chinese medicinal preparation for treating chronic renal disease and a preparation method thereof. The traditional Chinese medicinal preparation is prepared from the following crude medicines in parts by weight: rheum officinale and safflower on (1-10):(10-1); the crude medicines are prepared into an injection, a freeze-dried powder injection or other oral preparations through certain extraction and purification processes. Animal experiments prove that the traditional Chinese medicinal preparation can be used for significantly improving the hemorheology indexes of mice infected by chronic glomerulonephritis and reducing serum IL-6, IL-8 and TNF-alpha levels; the preparation can be used for remarkably reducing serum urea nitrogen and serum creatinine contents of mice of chronic renal failure and increasing a serum albumin content; moreover, the preparation can be used for improving the various hemorheology indexes and levels of mice of chronic renal failure; a pathological result shows that the traditional Chinese medicinal preparation disclosed by the invention can be used for improving and inhibiting damage of chronic kidney disease and chronic renal failure on kidney; furthermore, the traditional Chinese medicinal preparation prepared by the optimal preparation method disclosed by the invention is more excellent than a traditional Chinese medicinal preparation prepared by a conventional method.

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method. The traditional Chinese medicine composition is prepared from the raw material medicines of rheum officinale and salvia miltiorrhiza in a weight ratio of 1-10:10-1 by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to the chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure; and the treatment effect of the traditional Chinese medicine preparation prepared by the preparation method provided by the invention is better than that of a traditional Chinese medicine preparation prepared by a conventional method.

The invention discloses applications of a qi regulating and blood circulation activation preparation in preparation of drugs for treatment or prevention of kidney injury. According to the present invention, the qi regulating and blood circulation activation preparation comprises four drugs such as litsea lancilimba merr, allium macrostemon bunge, ligusticum chuanxiong hort and borneol, can significantly down-regulate the serum creatinine (Scr) increase, the urea nitrogen (BUN) increase and the MDA increase caused by kidney injury, and can significantly up-regulate the SOD activity reducing caused by kidney injury; and the clinical trial results show that the qi regulating and blood circulation activation preparation can provide advantages of high effectiveness and good treatment effect inthe treatment of kidney injury, provides the new treatment approach for the treatment of kidney injury, and expands the clinical application of the qi regulating and blood circulation activation preparation.

The invention provides an application of lupinone in preparing a medicine for treating kidney damage, and provides a new idea for the development of the medicine for treating kidney damage. The invention also includes the application of lupinone for preparation of health products for treating kidney or kidney damage, the lupinone is easily available and can drive the full development and utilization of medicinal materials. Specifically, the lupinone can reduce urea nitrogen and blood creatinine in serum, the lupinone can reduce fibrous tissue proliferation and inflammatory cell infiltration, and has certain protective and repairing effects on kidney tissue damage.

The invention provides a traditional Chinese medicine composition for treating diabetic nephropathy. The traditional Chinese medicine composition is prepared from 5-30 parts of raw radix astragali, 5-20 parts of radix codonopsis, 5-20 parts of prepared fructus corni, 5-20 parts of herba lycopi, 5-20 parts of rhizoma alismatis, 5-30 parts of radix ranunculi ternati, 10-40 parts of rhizoma smilacis glabrae, 5-20 parts of caulis piperis futokadsurae, 5-20 parts of rhizoma dioscoreae nipponicae, 5-20 parts of radix trichosanthis, 5-20 parts of radix angelicae sinensis and 5-20 parts of rhizoma curcumae. The invention further provides a traditional Chinese medicine preparation prepared from the traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine composition is complete in monarch, minister, assistant and guide, rigorous in compatibility and complementary, has the effects of reinforcing the kidney, dispelling wind, removing turbidity and harmonizing collaterals, has a remarkable effect of improving clinical syndromes of the diabetic nephropathy, can reduce serum creatinine, urea nitrogen and urine protein of patients with the diabetic nephropathy, has a good kidney protection effect and has a good application prospect.

The invention relates to a traditional Chinese medicine composition for treatment of chronic kidney failure and a preparation method, a preparation and use thereof, and belongs to the field of clinical treatment of traditional Chinese medicines. The traditional Chinese medicine composition for treatment of chronic kidney failure includes the following four groups of raw materials by weight: an A group selected form 10-25 parts of torrefied rhubarb and / or raw rhubarb; a B group selected form 11-18 parts of salvia miltiorrhiza and / or cortex moutan; a C group selected form 11-18 parts of red peony root and / or cortex moutan; and a D group including 10-14 parts of Chinese angelica, 25-50 parts of raw bone fossil of big mammals, 25-50 parts of raw oysters and 10-20 parts of dandelion. The traditional Chinese medicine composition used in treatment can improve clinical symptoms, reduces serum creatinine, increases endogenous creatinine clearance rate, increases the content of hemoglobin, achieve the curative effect in the treatment of chronic renal failure and complications thereof, delays the progression of the chronic renal failure, and protects the residual renal function, delays dialysis of patients, improves the survival rate and life quality of the patients, reduces medical expenses, reduces family and society burden, and is worthy of popularization and application.

The invention relates to the technical field of diabetic nephropathy, in particular to a medicine for treating and preventing diabetic nephropathy, which comprises 10 to 100 mg of tianagliflozin and 10 to 50 mg of DPP24 inhibitor. The medicine prepared by the invention can remarkably reduce the content or expression quantity of blood urea nitrogen, blood creatinine, 24h urine protein, urine protein quantification and transforming growth factor-beta1, remarkably improves the expression quantity of the klotho protein, has a better effect of treating and preventing diabetic nephropathy, can be stored for a long time, and has small toxic and side effects.

The invention discloses a hippophae rhamnoides extract capable of preventing and treating gout. The hippophae rhamnoides extract is prepared by the following steps: taking a certain amount of hippophae rhamnoides, crushing and sieving, adding a certain amount of solvent for extraction, filtering, merging filtrate and concentrating to obtain the hippophae rhamnoides extract. Animal experiment research shows that the hippophae rhamnoides fruit extract with the gout prevention and treatment effect can remarkably reduce the uric acid and blood urea nitrogen level of an acute hyperuricemia model mouse. In the experiment process, although the allopurine with a large dose of a positive drug has an obvious uric acid reducing effect, the allopurine has an obvious renal injury effect, and compared with a model group, the allopurine can obviously increase serum creatinine and blood uric acid nitrogen levels. And the sea-buckthorn extract, especially the water extract and ethanol extract of sea-buckthorn, can reduce the blood uric acid level and the blood urea nitrogen level, has no obvious influence on the serum creatinine level, has no obvious adverse reaction, and is safer in clinical application.

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and its preparation method and use. The traditional Chinese medicine composition is prepared from the raw material medicines of rheum officinale, astragalus and safflower with a weight ratio of 3-45:9-85:3-65 by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum creatinine and urea nitrogen and other indexes of rats subjected to hypertensive nephropathy, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; and pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure.

The invention discloses an application of a secretory leukocyte protease inhibitor (SLPI) as a prognostic marker of diabetic nephropathy (DN). Researches prove that the expression of the SLPI in renaltubular epithelial cells of a DN patient is increased, the expression of the SLPI in urine is also increased, the expression of the SLPI is significantly related to the decrease slope of the glomerular filtration rate (eGFR) of the DN patient, and the prognosis of the patient can be predicted. By detecting kidney tissue sections and urine of the DN patient, the inventor finds that the mRNA and protein levels of SLPI in renal tubules of the DN patient are remarkably increased, the expression level of SLPI in urine is increased in parallel with the protein level of the kidney, and prognosis ofthe DN patient can be effectively predicted and is superior to that of serum creatinine or proteinuria.

The invention relates to the technical field of serum creatinine determination, and in particular relates to a serum creatinine detection reagent ball and a serum creatinine detection chip. According to the serum creatinine detection reagent ball and the serum creatinine detection chip containing the serum creatinine detection reagent ball, interference of vitamin C in a detection sample can be eliminated through ascorbic acid oxidase, and interference of bilirubin can be eliminated by taking a bilirubin interference removing agent as an oxidizing agent; interference of endogenous creatine, sarcosine and peroxide existing in a detection sample is eliminated through creatinase, sarcosine oxidase and peroxidase respectively. The serum creatinine detection reagent ball and the serum creatinine detection chip provided by the invention have relatively strong anti-interference capability on original interferents in serum and drug interferents taken by patients, and the precision of a detection result is high.

The invention relates to a traditional Chinese medicine for treating nephrotic syndrome, comprising the following components by weight portion: 90-150 portions of umbellate pore furgus, 50-90 portions of mangnolia officinalis, 10-60 portions of unprocessed rhizoma pinelliae, 10-60 portions of ginseng and 10-60 portions of ligusticum wallichii. The traditional Chinese medicine is prepared from hundreds of selected traditional Chinese medicines, has reasonable collocation and accurate medication, achieves the purposes of supporting healthy energy and treating the primary and the secondary aspects at the same time through the function of mutual cooperation among the medicines, and does not have any toxic or side effect. The invention adjusts the systemic immune function by tonifying the kidney, invigorating blood circulation and expelling toxin, restores glomerular basement membrane, eliminates immune complex, lightens or eliminates urokinase protein and occult blood, promotes renal microcirculation, fastens renal metabolism, actives renal units, enables kidney to restore normal size, strengthens detoxification function, and enables toxin of serum creatinine, urea nitrogen, and the like to be exhausted from urine.

The invention provides a method for detecting or quantifying creatinine and an immunosuppressive drug selected from tacrolimus and ciclosporin in a blood sample, devices, including lateral flow assay devices, and kits, as well as methods that enables the reduction of nephrotoxicity and / or enables the maintenance of good renal function in an organ or tissue transplant patient who is undergoing treatment with an immunosuppressive drug selected from tacrolimus and ciclosporin, and methods for monitoring nephrotoxicity and / or kidney function in transplant patients.

The invention discloses a traditional Chinese medicine composition for treating chronic renal failure. The raw material comprises the following parts by weight: 25-35 parts of Allium, 1-5 parts of Cordyceps sinensis, 25-35 parts of Astragalus, 10-20 parts of Angelica, 15-25 parts of fairy spleen, 15-25 parts of Eucommia, 10-20 parts of Chinese yam , 10-20 parts of Atractylodes macrocephala, 5-15 parts of turtle shell, 10-20 parts of Moutan bark, 5-15 parts of cassia twig, 10-15 parts of rhubarb, 25-35 parts of Poria cocos, 10-20 parts of Alisma, 10-20 parts 15-25 parts of Polyporus, 15‑25 parts of Sichuan Achyranthes bidentata. Allium scallion is the king drug, and it was accidentally discovered that it has the effect of promoting yang and diuresis. The compatibility of the prescription can significantly improve the patient's clinical symptoms. The patient's edema subsides significantly, and the urine output increases. It has few side effects and low cost, can improve the quality of life of patients, and is beneficial to clinical popularization and application.

The invention discloses a serum creatinine detection card for optical differential signal processing and a preparation method and application thereof.The serum creatinine detection card is composed of an upper card shell, a lower card shell, a diffusion layer, a filtering reaction layer, a separation reaction layer and a chromogenic reaction layer, the filtering reaction layer is provided with creatininase and creatine hydrolase, the separation reaction layer is provided with sarcosine oxidase and anti-interference enzyme liquid, and the chromogenic reaction layer is provided with an anti-interference enzyme liquid. Chromatogen substrates and catalase are arranged on the chromogenic reaction layer, serum is obtained through treatment and separation of the diffusion layer, the filtering reaction layer and the separation reaction layer, creatininase method step-by-step reactions are carried out on different layers respectively, enzyme liquid is arranged in a layered mode, and the substrate concentration and the enzyme liquid concentration are beneficial to full reaction of all steps; reaction by-products of all the steps cannot influence enzyme liquid of other reaction steps and the reaction process, interference is reduced, creatinine and creatine are reacted and converted to the maximum extent, the content of serum creatinine is rapidly, accurately and quantitatively detected, the accuracy and stability of the detection result are greatly improved, use is easy, and operation by professionals is not needed.

The invention discloses novel application of an FOXO1 selective inhibitor AS1842856. The novel application of the AS1842856 (formula I) provided by the invention is the application of the AS1842856 inpreparation of a medicine for preventing and / or treating the diabetic kidney disease. Pharmacodynamic experiments in the invention prove that: by applying AS1842856, the levels of serum creatinine and blood urea nitrogen in diabetic kidney disease injury can be obviously reduced; infiltration of kidney tissue macrophages is inhibited; and the application prospect in the aspect of kidney protection is good.

The invention discloses the application of niclosamide ethanolamine salt in preparation of a medicine for treating systemic lupus erythematosus and complications thereof. The niclosamide ethanolaminesalt (NEN) can reduce the serum anti-ds-DNA antibody level, reduce the MRL / lpr mouse proteinuria excretion, reduce the serum creatinine and serum urea nitrogen level, improve glomerulosclerosis and renal tubule interstitial injury, relieve the spleen swelling, relieve lymph node hyperplasia swelling and relieve the skin injury.

The invention discloses a traditional Chinese medicine for treating chronic renal failure and a preparation method for the traditional Chinese medicine. The traditional Chinese medicine provided by the invention has the effects of facilitating bowel movement, defecting, clearing away heat and toxins, promoting blood circulation to remove blood stasis, promoting diuresis, relaxing the bowels and eliminating swollen sore; particularly by virtue of the adding of long stephania herb, which is a special kiln medicine in Guangxi, the effects of calming the adverse-rising energy, defecting, reducing serum creatinine and uremia toxins such as urea nitrogen and uric acid can be achieved; the problems of red and swollen anuses and rectum mucosas which are caused in a colon dialysis process and the like are solved, and the dialysis effect is effectively enhanced.