Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of physically-modified Chinese cobra venom in preparation of medicament for treating acute and chronic nephrosis

A Chinese cobra and cobra venom technology, applied in the direction of drug combination, medical raw materials derived from reptiles, medical preparations containing active ingredients, etc. High efficiency and large effective range

Active Publication Date: 2013-01-02
SUZHOU RENBEN PHARMA
View PDF2 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nephrotic syndrome is a relatively difficult disease to cure clinically, and proteinuria is the main diagnostic index clinically. At present, the drug treatment for nephrotic syndrome is still based on prednisone and other glucocorticoids, but long-term application of side effects large and prone to recurrence

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of physically-modified Chinese cobra venom in preparation of medicament for treating acute and chronic nephrosis
  • Application of physically-modified Chinese cobra venom in preparation of medicament for treating acute and chronic nephrosis
  • Application of physically-modified Chinese cobra venom in preparation of medicament for treating acute and chronic nephrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0046] The above solution will be further described below in conjunction with specific embodiments. It should be understood that these examples are used to illustrate the present invention and not to limit the scope of the present invention. The implementation conditions adopted in the examples can be further adjusted according to the conditions of specific experiments, and the implementation conditions not indicated are usually the conditions in routine experiments.

[0047] The animal pharmacodynamics experiment of the Chinese cobra snake venom after embodiment physical treatment

[0048] (1) Acute kidney disease experiment in rats induced by glycerol

[0049] In this experiment, after the rats were deprived of water for 24 hours, 50% glycerol was injected intramuscularly into both sides of the buttocks according to the weight of the rats at 8ml / kg to reproduce the acute kidney disease model. The Wistar rats were randomly divided into 5 groups: normal saline control group a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of physically-modified Chinese cobra venom in preparation of medicaments for treating acute and chronic nephrosis. The physically-modified Chinese cobra venom is obtained by dissolving Chinese cobra venom with deionized water, heating for denaturation and then performing renaturation; the heating temperature is controlled to be 50-100 DEG C, and the heating time is controlled to be 1 min-300 min. The invention finds that the heated and denaturated Chinese cobra venom can effectively reduce urine protein in acute and chronic nephrosis, reduce serum creatinine, and urea nitrogen, improve the pathological damage degree of the kidney, and recover kidney functions.

Description

technical field [0001] The invention relates to the use of physically modified Chinese cobra venom in the preparation of medicines for treating acute and chronic kidney diseases. Background technique [0002] Snake venom is a complex mixture of components secreted by the snake's venom glands. Snake venom is a complex mixture of components secreted by the snake's venom glands. Fresh venom is egg white-like viscous liquid with a special fishy smell. The venom of different snake species has different colors, and the venom of the Chinese cobra is light yellow. More than 90% of the dry matter of snake venom is protein, which is the main component of its toxicity and biological activity. The components of Chinese cobra venom mainly include cobra venom factor (1%-2%), cardiotoxin (40%-50%, also known as cytotoxin, membrane toxin), neurotoxin (10%) and other proteins. The traditional medicine of the motherland believes that cobra and its toxic components can clear the meridians,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K35/58A61P13/12A61K35/583
Inventor 秦正红王姝之何鹤
Owner SUZHOU RENBEN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com