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Hippophae rhamnoides extract with gout prevention and treatment effect and application thereof

An extract and technology of seabuckthorn, applied in the field of seabuckthorn extract and its preparation, can solve the problem of low adverse reactions, achieve the effects of no toxic side effects, convenient administration, and lower blood urea nitrogen levels

Pending Publication Date: 2022-06-24
JIANGSU PROVINCIAL HOSPITAL OF TCM +1
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0004] At present, there is no information showing that seabuckthorn water extract and ethanol extract are clinically used for the treatment of gout; Traditional Chinese medicine preparation with low adverse reactions

Method used

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  • Hippophae rhamnoides extract with gout prevention and treatment effect and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A seabuckthorn water extract with the effect of preventing and treating gout is prepared by the following method: take a certain amount of seabuckthorn, pulverize it through a No. 1 sieve, obtain coarse powder, add water according to the weight-volume ratio of medicinal materials and solvent 1:100, Extraction by heating and refluxing for two times, 1 h each time, combined filtrates, and the solvent was recovered under reduced pressure at 55 °C to obtain a concentrated solution.

Embodiment 2

[0021] A sea buckthorn ethanol extract with the effect of preventing and treating gout is prepared by the following method: taking a certain amount of sea buckthorn, pulverizing it through a No. 1 sieve to obtain coarse powder, adding ethanol according to the weight-volume ratio of medicinal materials and solvent 1:100 , extracted twice under reflux for 1 h each time, combined the filtrates, and recovered the solvent under reduced pressure at 55 °C to obtain a concentrated solution.

Embodiment 3

[0023] The preparation method is the same as that in Example 1, and the extraction solvent adopts petroleum ether.

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Abstract

The invention discloses a hippophae rhamnoides extract capable of preventing and treating gout. The hippophae rhamnoides extract is prepared by the following steps: taking a certain amount of hippophae rhamnoides, crushing and sieving, adding a certain amount of solvent for extraction, filtering, merging filtrate and concentrating to obtain the hippophae rhamnoides extract. Animal experiment research shows that the hippophae rhamnoides fruit extract with the gout prevention and treatment effect can remarkably reduce the uric acid and blood urea nitrogen level of an acute hyperuricemia model mouse. In the experiment process, although the allopurine with a large dose of a positive drug has an obvious uric acid reducing effect, the allopurine has an obvious renal injury effect, and compared with a model group, the allopurine can obviously increase serum creatinine and blood uric acid nitrogen levels. And the sea-buckthorn extract, especially the water extract and ethanol extract of sea-buckthorn, can reduce the blood uric acid level and the blood urea nitrogen level, has no obvious influence on the serum creatinine level, has no obvious adverse reaction, and is safer in clinical application.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, in particular to a seabuckthorn extract with the effect of preventing and treating gout, and a preparation method and application thereof. Background technique [0002] Gouty Arthritis is a crystal-related joint disease caused by the deposition of monosodium urate (MSU). Rheumatism category. At present, the prevalence of gout in the world is increasing year by year and has a trend of younger development. The prevalence of gout in my country is about 0.15%-0.67%, which has an obvious upward trend compared with the previous one. Studies have shown that gout is closely related to metabolic syndrome, cardiovascular disease, kidney disease, etc., and can be complicated by kidney disease. In severe cases, joint destruction and kidney function damage may occur, often accompanied by hyperlipidemia, hypertension, diabetes, and arteriosclerosis. And coronary heart disease and other hazards, seri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P19/06
CPCA61K36/185A61P19/06A61K2236/331A61K2236/33
Inventor 孙云飞罗美慧
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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