52 results about "Nootkatone" patented technology

The invention discloses an essence for cigarette mouth building adhesive and preparing and using method thereof. The cigarette mouth building adhesive is made by evenly mixing 25 parts of Yunnan tobacco extract, 3 parts of nootkatone, 25 parts of tobacco flavouring group, 2 parts of rose essential oil, 3 parts of dihydroactinidiolid, 2 parts of Beta-damascone and 40 parts of dissolvent. After the essence and the conventional mouth building adhesive are doped, the original perfume of the tobacco can be improved obviously, various of perfumes of the cigarette can be regulated, the cigarette perfume is more natural, soft and elegant. The cigarette adhesive processed by the technology, the adhesion efficiency can not be reduced. According to the invention, the preparing method is easy, the costs are low, the invention can be applied to the large-scale industrial production.

Extracts of vetiver oil were found to significantly repel termites. In one extract, nootkatone was isolated and found to be a significant repellent and toxicant of termites. Nootkatone significantly decreased food consumption, decreased tunneling behavior, and increased mortality in termites. Nootkatone is an effective repellent and toxicant of termites either by itself or as an addition to other materials or substrates, including mulches made from vetiver grass roots or other wood products. Nootkatone can also be used to protect construction wood from attack by Formosan subterranean termites. Nootkatone as a repellent is non-toxic to humans and other mammals and is environmentally safe. In addition, α-cedrene was found to be a weak termite repellent; and both zizanol and bicyclovetivenol were found to be repellents and toxicants of termites.

Sweet orange daily chemical essence is disclosed, and mainly used in daily chemical products. The sweet orange daily chemical essence comprises following components by weight: 0.01-0.30% of aldehyde type perfume, 0-0.30% of alcohol type perfume, 0-0.50% of ester type perfume, 0.01-0.05% of ethyl maltol, 0.01-0.05% of nootkatone, 0-2.20% of alkene type perfume and 0.01-10% of plant essence oil, with the balance being ethanol. The sweet orange daily chemical essence is used in daily chemical products and the daily chemical products can have a flavor that is the same as natural sweet orange and is natural.

The present invention relates to provision of AMPK activating agent, endurance enhancing agent, and antifatigue agent, which have rich history of use in foods, high safety, readily available, and high workability, a method of activating AMPK, and a method of preventing, treating and / or ameliorating a life-style-related disease. The present invention provides AMPK activating agent, endurance enhancing agent, and antifatigue agent, each of which contains nootkatone as an active agent. The present invention provides a method of activating AMPK characterized by administering nootkatone in an effective amount, and a method of preventing, treating and / or ameliorating a life-style-related disease characterized by administering nootkatone in an effective amount.

A method for extracting and purifying natural perfume that is valencene and nootkatone in the walnut extracts and purifies valencene and nootkatone by the processes of supercritical fluid extraction, dissolvant liquid-liquid extraction, high precision fractionation, preparing chromatography, and recrystallization in turns, comprising: extracting the walnut by fluid under a supercritical state, performing a liquid-liquid extraction using lower alcohol solution through an emulsification pump and a homogenizer, mixing the walnut oil and alcohol solution, emulsifying the solution to achieve a full liquid-liquid contact and extraction, the high precision fractionation using vacuum fractionation, fractionating hydrocarbons component of the walnut oil after liquid-liquid extraction to obtain valencene, using polyporous material as a chromatography fillers, chromatographically separating and recrystallizing a crude product of nootkatone obtained form alcohol solution after liquid-liquid extraction to obtain the purified nootkatone.

The invention discloses a quality detection method for Liangfu (of which the main compositions are rhizoma alpiniae officinarum and rhizoma cyperi) pill-like preparations. The method is a thin-layer chromatography method, and detection is performed by taking alpha-cyperone, cyperotundone, nootkatone, galangin and kaempferol as index components. The expansion conditions of the thin-layer chromatography comprise petroleum ether and ethyl acetate with the volume ratio of 5:1, and the thin-layer plate is silica gel GF254 plate. The quality detection method is capable of simultaneously detecting five index components in the Liangfu pill-like preparations, the environment adaptability is high, the method is simple, separation of the index components is good, and effective guarantee is provided for comprehensive detection on the quality of the Liangfu pill-like preparations.

The invention discloses an HPLC detection method for alpinia-cyperus preparations. The HPLC method is used for simultaneous determination of the contents of 5 components, namely galangin, kaempferide, sweet ketene, nootkatone and alpha-cyperone, in the alpinia-cyperus preparations. The HPLC method comprises the following steps: (1) establishing a standard curve of galangin, kaempferide, sweet ketene, nootkatone and alpha-cyperone; (2) determining the contents of galangin, kaempferide, sweet ketene, nootkatone and alpha-cyperone in a sample to be detected. According to the HPLC detection method provided by the invention, various components in the alpinia-cyperus preparations can be determined simultaneously. The HPLC method is high in specificity, can comprehensively reflect information, is simple and convenient, quick and accurate, and is accurate and reliable in determination result, so that the quality of the alpinia-cyperus preparations can be effectively monitored, and the medicine safety is improved.

The invention discloses a sharpleaf galangal fruit extract capable of treating chronic kidney diseases. The extract is prepared by the following steps: grinding sharpleaf galangal fruits to remove the shells, adding a certain amount of ethanol, carrying out reflux extraction, collecting the extract, making the extract go through macroporous resin, eluting the macroporous resin by low-concentration ethanol to remove the impurities, then eluting the macroporous resin by high-concentration ethanol, condensing to obtain extract, separating the extract in a silica gel column, and carrying out crystallization so as to obtain the sharpleaf galangal fruit extract. According to the pathogenesis of chronic kidney diseases and on the basis of traditional Chinese medicine theory, the inventor researches the chemical components and the clinical curative effect of sharpleaf galangal fruit. The results of a great number of experiments show that the prepared sharpleaf galangal fruit extract (nootkatone) can prominently reduce proteinuria, can also obviously reduce the levels of serum creatinine and urea nitrogen, has a good kidney protective effect, and can be used to prevent and treat chronic kidney diseases.

The invention relates to an apple flavor enhancement agent and an apple flavor enhancement method. A conventional apple flavor fragrance can fully reproduce top-level apple aroma to middle-level fruit aroma and fruit feeling, but pulp feeling of the apple and juicy pulp feeling that spreads in the mouth when gnawing the whole apple are lacked. A small amount of sinensal and / or nootkatone is added into apple flavor food and drink or apple flavor perfume, so that sweet pulp feeling as well as hard and crunchy pulp feeling when gnawing the apple which can not be reproduced in the prior art are accompanied, furthermore apple-like aroma and flavor can be reproduced and enhanced.

A method for enhancing endurance and / or for removing fatigue by administering to a subject in need thereof a composition containing an effective amount of nootkatone. The method may be further combined with exercise.

This disclosure relates to a method for the control or repellency of biting arthropods. The method comprises bringing the biting arthropods into contact with a biting arthropod repellent formulation. The biting arthropod repellent formulation comprises an alkoxy nootkatone separate from, or in combination, or in synergistic combination, with skin or plant derived compounds and compounds structurally similar to them (e.g., ketones, cyclic ketones, esters, gamma or delta lactones, and branched and / or unsaturated carboxylic acids), and / or one or more repellents selected from the group consisting of DEET®, para-menthane-3,8-diol (PMD), Picaridin, ethyl 3-[acetyl(butyl)amino]propanoate (IR3535), and other nitrogen-containing repellents including amines, amides, and nitrogen-containing heterocyclic compounds. This disclosure also relates to a biting arthropod repellent formulation comprising an alkoxy nootkatone separate from, or in combination, or in synergistic combination, with the skin or plant derived compounds and compounds structurally similar to them, and / or the one or more repellents.

A process for preparing the nootkatone used for essence of cigarette includes such steps as extracting valencene from valerian oil by supercritical separation, and converting it to nootkatone in the solution of sodium hypochlorite-tert-butyl hydrogen peroxide (TBHP) mixture.

The invention discloses grapefruit essence for water-based ink. The grapefruit essence for the water-based ink consists of the following ingredients in percentage by weight: 1 to 30 percent of grapefruit essence, 5 to 55 percent of composite modified oligosaccharide and deionized water, wherein the grapefruit essence consists of grapefruit oil, nootkatone, sweet orange oil, lemon oil, tangerine oil, capraldehyde, caprylaldehyde, ethyl butyrate, octyl acetate, linalool, linalyl acetate, terpilenol, terpinyl acetate and ethyl alcohol. The invention also provides a preparing method of the grapefruit essence for the water-based ink. According to the preparing method, the composite modified oligosaccharide is used as a wall material; the grapefruit essence is coated to form grapefruit nanocapsule slow-release essence, so that the fragrance retention and the water solubility of the essence are improved; the preparing method is applicable to the perfuming of the water-based ink. The grapefruit essence for the water-based ink has the advantages that the fragrance is fresh, intensive and lifelike; the natural feeling is high; the fragrance retention is durable.

An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are inexpensive and the reactions are commercially feasible and amenable to scaling up. The principal starting material, (-)-[beta]-Pinene, is on the GRAS list (generally recognized as safe).

The invention relates to biting arthropod repellent compositions comprising nootkatone. The application also relates to a method of repelling said biting arthropods by application of the nootkatone composition to a hard or soft surface, to a method of treating an arthropod infestation and to a method of reducing the transmission of a parasite or disease pathogen spread by a biting arthropod using the nootkatone composition.

The disclosure discusses chiral dopants for liquid-crystalline materials. Chiral dopants can be bioreachable compounds, i.e., compounds produced from microbes through fermentation. Chiral dopants can also include bioreachable materials that are further modified by chemical synthetic steps. Chiral dopants as discussed herein can include biomolecules such as glycyrrhetinic acid (1), S-narigenin (2), shikimic acid (3), alpha-phellandrene (4), betulin (5), malic acid (6), valencene (7), or nootkatone (8), and any stereoisomers or chemically modified derivatives thereof. The disclosure further shows optical properties of such compounds in a liquid-crystalline material.

Methods for repelling and killing ticks as well as for detaching attached and feeding ticks from the skin of a subject by application of a composition comprising nootkatone to the tick are disclosed.

An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed. The starting materials used in the synthesis are inexpensive. The principal starting material, (-)-beta-Pinene, is on the GRAS list (generally recognized as safe).

The invention discloses citron-lemon essence and a preparation method thereof. Raw materials comprise lemon oil, sweet orange oil, cold-pressed orange oil, citron oil, lemon oil, orange leaf oil, limonene, leaf alcohol, nerol, cis-6-nonene, alcohol, linalool oxide, menthone sulfide, nootkatone, leaf alcohol acetate, geranyl propionate, 2-methylbutyrate leaf alcohol ester, geranyl acetate, citronellyl acetate, nerol acetate and a solvent. The preparation method comprises the steps: uniformly mixing all the raw materials in proportion, and standing for 48 hours to obtain the citron-lemon essence. The citron-lemon essence disclosed by the invention is harmonious and vivid in fragrance and has certain thermal stability. The citron-lemon essence can be used as an additive for daily use chemicals and foods, and is added into beverages, cosmetics and detergents.

The invention discloses a technology for extracting nootkatone from shaddock peel. Simultaneous distillation-extraction and molecular imprinting template extraction are organically combined, nootkatone volatile oil is extracted from the shaddock peel through the simultaneous distillation-extraction, the volatile oil is extracted and separated by an extracting agent containing a molecular imprinting template, high-purity nootkatone is obtained, and the technology is simple and convenient to operate, has low requirement for equipment and facilitates industrial production; in the step of extracting and separating the volatile oil by the extracting agent containing the molecular imprinting template, types and dosages of solvents, functional monomers, cross-linking agents and initiators are selected, so that polymerization conditions are optimized, molecularly imprinted polymers with better particle size distribution and physical stability and good adsorptive property are prepared, nootkatone can be recognized selectively, adsorption extent of nootkatone is high, and the technology has good extraction performance.

The invention discloses a series of novel nookatone thioether derivatives each containing a 1,3,4-oxadiazole ring, and a preparation method and application of the novel nookatone thioether derivatives. According to the series of compounds, nootkatone serves as a raw material, chlorine atoms are introduced to the allyl position of nootkatone to synthesize 13-chloro nootkatone, the 13-chloro nootkatone and 5-aryl-2-sulfydryl-1,3,4-oxadiazole are subjected to a substitution reaction to generate a series of novel nootkatone derivatives, and the structural general formula of the nootkatone derivatives is shown in the formula (I). According to the nootkatone thioether derivatives, the 1,3,4-oxadiazole group has various biological activities, especially in the aspect of insecticidal activity, after the nootkatone thioether derivative is combined with nootkatone, the derivative has good insecticidal activity, and the nootkatone thioether derivative is expected to be used for preparing a novel natural product insecticide; and the compound is simple in preparation process, low in cost and relatively non-toxic to non-standard target biological fish and shrimp seeds. In the formula, R is selected from non-substituted or substituted phenyl or pyridyl, and the substituted phenyl is phenyl substituted by halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro or cyano.

The invention discloses a method for identifying Fujian Guanxi honey pomelos by a chromatography method. According to the method, firstly, acetonitrile is used for extracting chemical ingredients in each position of outer peels, endodermis, endocarp, pulp and the like of the honey pomelos; then, a gas chromatograph, a hydrogen flame ionization detector and a liquid chromatogram-ultraviolet detector is used at the same time for detection; chemical ingredients in each position of the Fujian Guanxi honey pomelos are subjected to chromatographic qualitative analysis; specific substances of cnidium lactone, limonene, alpha-linoleic acid, palmitic acid, sitosterol, oleamide and nootkatone and the like in the Fujian Guanxi honey pomelos can be accurately detected; a honey pomelo specific substance chromatographic fingerprint chromatogram is successfully built. The method provided by the invention has the advantages that the operation is simple; the qualitative detection is accurate; the detection is fast; the method belongs to a fire-new fast, accurate and simple honey pomelo origin traceability and quality identification method.

This disclosure relates to a method for the control or repellency of biting arthropods. The method comprises bringing the biting arthropods into contact with a biting arthropod repellent formulation. The biting arthropod repellent formulation comprises nootkatone in combination, or in synergistic combination, with skin or plant derived compounds and compounds structurally similar to them (e.g., ketones, cyclic ketones, esters, gamma or delta lactones, and branched and / or unsaturated carboxylic acids), and / or one or more repellents selected from the group consisting of DEET®, para-menthane-3,8-diol (PMD), Picaridin, ethyl 3-[acetyl(butyl)amino]propanoate (IR3535), and other nitrogen-containing repellents including amines, amides, and nitrogen-containing heterocyclic compounds. This disclosure also relates to a biting arthropod repellent formulation comprising nootkatone in combination, or in synergistic combination, with the skin or plant derived compounds and compounds structurally similar to them, and / or the one or more repellents.

The invention relates to methods for producing glycosylated nootkatol. In particular, a recombinant host comprising a gene encoding a UDP-glycosyltransferase polypeptide capable of glycosylating nootkatol is disclosed. Glycosylation of nootkatol detoxifies nootkatol, allowing for greater production of (glycosylated-)nootkatol, a precursor of nootkatone, and therefore greater production of nootkatone. The invention also relates to methods of converting non-toxic, glycosylated nootkatol produced by a recombinant host to nootkatol, wherein the nootkatol can subsequently be converted to large quantities of nootkatone to be used in flavorings, perfumes, and / or insect repellents.

The invention relates to an apple flavor enhancement agent and an apple flavor enhancement method. A conventional apple flavor fragrance can fully reproduce top-level apple aroma to middle-level fruit aroma and fruit feeling, but pulp feeling of the apple and juicy pulp feeling that spreads in the mouth when gnawing the whole apple are lacked. A small amount of sinensal and / or nootkatone is added into apple flavor food and drink or apple flavor perfume, so that sweet pulp feeling as well as hard and crunchy pulp feeling when gnawing the apple which can not be reproduced in the prior art are accompanied, furthermore apple-like aroma and flavor can be reproduced and enhanced.

Methods for repelling and killing ticks as well as for detaching attached and feeding ticks from the skin of a subject by application of a composition comprising nootkatone to the tick are disclosed.

A method for extracting and purifying natural perfume that is valencene and nootkatone in the walnut extracts and purifies valencene and nootkatone by the processes of supercritical fluid extraction, dissolvant liquid-liquid extraction, high precision fractionation, preparing chromatography, and recrystallization in turns, comprising: extracting the walnut by fluid under a supercritical state, performing a liquid-liquid extraction using lower alcohol solution through an emulsification pump and a homogenizer, mixing the walnut oil and alcohol solution, emulsifying the solution to achieve a full liquid-liquid contact and extraction, the high precision fractionation using vacuum fractionation, fractionating hydrocarbons component of the walnut oil after liquid-liquid extraction to obtain valencene, using polyporous material as a chromatography fillers, chromatographically separating and recrystallizing a crude product of nootkatone obtained form alcohol solution after liquid-liquid extraction to obtain the purified nootkatone.

The invention relates to the field of microorganisms, in particular to a Burkholderia and application thereof. A method for preparing the Burkholderia comprises the following steps: firstly, performing preliminary screening, diluting a sample bacterial suspension, coating a flat plate with the diluted sample bacterial suspension, picking a single colony, taking valencene as a unique carbon source,drawing a growth curve for preliminary screening, and selecting a well-growing strain for a next experiment; secondly, performing secondary screening, analyzing and comparing the yield of nootkatonewhich is generated by biological conversion of the valencene through the strain, and selecting a strain with high yield of the nootkatone for a next experiment; and performing streaking on the selected strain, and analyzing and determining a product obtained by the biological conversion of the valencene through the strain and the content of the product. Compared with the conventional physical andchemical synthesis methods, the method for preparing the Burkholderia has the characteristics of high specificity, mild reaction conditions, high reaction rate, high yield, low cost, few reaction steps and the like; moreover, the nootkatone produced in such a way belongs to a natural spice and can be added into foods, cosmetics and other household products.