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Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use

A technology for chronic kidney disease and chronic renal failure, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients. Can not guarantee the combined effect and other problems, to achieve the effect of simplifying the formula properly, improving the symptoms of blood stasis, and shortening the extraction time

Active Publication Date: 2014-07-02
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there have been reports on the treatment of acute renal failure with rhubarb combined with compound danshen injection and the treatment of chronic renal failure with compound rhubarb enema and compound danshen injection. An optimal combined use ratio cannot guarantee the best combined use effect; the combined drug may also contain some other drug ingredients and excipient ingredients that do not treat the disease, resulting in waste of drug resources and increased drug risks
In addition, the existing reports all use rhubarb preparation and Danshen preparation to treat kidney disease separately, and there is no report on the direct compatibility of rhubarb and Danshen for the treatment of chronic kidney disease and chronic renal failure.

Method used

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  • Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use
  • Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use
  • Traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method and use

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Effect test

Embodiment 1

[0109]Take 1000g of rhubarb and 1000g of salvia miltiorrhiza, crush them into coarse particles, add 8 times the amount of water to soak for 20 minutes, heat and ultrasonically extract for 20 minutes for the first time, filter; Concentrate under pressure to a relative density of 1.21 at 60°C, add 5% gelatin solution to remove tannin, filter, add ethanol to make the alcohol content 75%, let stand, filter, take the filtrate and concentrate under reduced pressure to a relative density of 1.21 at 60°C , recover ethanol, continue to add ethanol to make the alcohol content 80%, let it stand, filter, recover ethanol, add water for injection to 2-3 times the amount of the liquid medicine, then add 0.3%-0.5% activated carbon, boil for 30min, filter , adjust the pH value to 7.4-7.7 to obtain rhubarb and Salvia miltiorrhiza extract, ultrafiltration, adjust the pH value to 7.4-7.7, the liquid medicine is filtered through a filter equipped with a microporous membrane, then filled and sealed,...

Embodiment 2

[0111] Take 1000g of rhubarb and 1000g of salvia miltiorrhiza, crush them into coarse particles, add 8 times the amount of water to decoct, combine the extracts, filter, collect the filtrate, concentrate, enter the macroporous resin column for adsorption and separation, and collect the first effluent; first elute with water, collect The eluate is then eluted with 50%-60% ethanol, the ethanol eluate is collected, the ethanol is recovered until there is no alcohol smell, the combined effluent is concentrated under reduced pressure to a relative density of 1.21 at 60°C, and 5% gelatin solution is added to remove Tannin, filter, add ethanol to make the alcohol content 75%, stand still, filter, take the filtrate and concentrate under reduced pressure to a relative density of 1.21 at 60°C, recover ethanol, continue to add ethanol to make the alcohol content 80%, let stand , filter, recover ethanol, add water for injection to 2-3 times the amount of the medicinal solution, then add 0....

Embodiment 3

[0113] Take 1000g of rhubarb and 1000g of salvia miltiorrhiza, crush them into fine particles and put them in the extraction kettle for CO 2 For supercritical extraction, the flow rate of the supercritical fluid entering the extraction kettle is 35L / h, the extraction pressure is 30MPa, the extraction temperature is 45°C, and the extraction time is 2.5h. The rhubarb and Danshen high-pressure fluids flowing out of the extraction kettle enter the separation kettle for Separation, separation pressure I is 8 Mpa, separation temperature I is 30°C; separation pressure II is 6 Mpa, separation temperature II is 25°C, collect the extracts of rhubarb and salvia miltiorrhiza, add water for injection to 2-3 times the amount of the liquid medicine , then add 0.3%-0.5% activated carbon, boil for 30min, filter, adjust the pH value to 7.4-7.7 to obtain the extract of rhubarb and salvia miltiorrhiza After being filtered by a filter, it is filled and sealed, and sterilized to make small-capacity...

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Abstract

The invention provides a traditional Chinese medicine composition for treatment of chronic renal diseases and chronic renal failure and its preparation method. The traditional Chinese medicine composition is prepared from the raw material medicines of rheum officinale and salvia miltiorrhiza in a weight ratio of 1-10:10-1 by a certain extraction and purification process into an injection, a freeze-dried powder injection or other oral preparations. Animal experiments confirm that, the traditional Chinese medicine composition can obviously improve the hemodynamic indexes of rats subjected to chronic glomerulonephritis, reduces serum IL-6, IL-8, and TNF (tumor necrosis factor)-alpha levels, significantly reduces serum urea nitrogen and serum creatinine contents of rats subjected to the chronic renal failure, increases serum albumin content, and also can improve each hemodynamic index of rats subjected to the chronic renal failure; pathological results show that the traditional Chinese medicine composition can improve and inhibit injures on kidney caused by the chronic renal diseases and chronic renal failure; and the treatment effect of the traditional Chinese medicine preparation prepared by the preparation method provided by the invention is better than that of a traditional Chinese medicine preparation prepared by a conventional method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a medicine for treating chronic kidney disease and chronic renal failure and a preparation method thereof. Specifically, it belongs to the field of medicine. Background technique [0002] Chronic Kidney Disease (CKD) clinically includes chronic glomerulonephritis, nephrotic syndrome, membranous nephropathy, diabetic nephropathy, hypertensive nephropathy and various secondary nephropathy, etc. The prevalence of vascular diseases is high and the mortality rate is high. In addition, the awareness rate of chronic kidney disease is low, the prevention rate is low, and the awareness rate of cardiovascular disease is low. It has become a global public health problem. Medically, CKD is diagnosed mainly from two aspects: (1) kidney damage (displaying abnormal kidney structure and function) for ≥ 3 months, with or without decreased glomerular filtration rate (GRF); (2) Glomer...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/19A61P13/12A61K36/537
Inventor 曹凤君吕延英詹芳王光建赵兴王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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