Application of verbascoside in treating and preventing type II diabetic nephropathy

Abstract

The invention relates to new application and a new action mechanism of verbascoside, in particular to application of verbascoside in the drugs for treating and preventing type II diabetic nephropathy,and the research on the protection function of the verbascoside for the type II diabetic nephropathy and the action mechanism thereof. Results show that the verbascoside can alleviate liver injury caused by high glucose and lower the serum creatinine, urea nitrogen and urinary microalbuminuria levels, the blood fat level (total cholesterol and triglyceride) and the fasting blood-glucose and bloodinsulin level of spontaneous diabetes db / db mice; TGF (Transforming Growth Factor)-beta 1 and the signal transduction protein Smad3 and Smad4 and alpha-SMA protein expression thereof in a kidney tissue are obviously lowered; meanwhile, the verbascoside can alleviate the liver injury caused by high glucose; HK-2 proliferation and EMT (pithelial-Mesenchymal Transition) formation can be inhibited. In conclusion, the verbascoside has an obvious protection function on the type II diabetic nephropathy, the action mechanism of the verbascoside is that the kidney protection function of the verbascoside is implemented through oxidative stress reaction regulation and control, TGF-beta / smad signaling channel inhibition and kidney fibrosis alleviation.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the application of verbascoside in the preparation of medicines or health care products for preventing or treating diabetic kidney damage. Background technique [0002] Actascoside is a representative component of phenylethanol glycosides, widely distributed in a variety of plant families and genera such as Verbenaceae, Lamiaceae, Scrophulariaceae, Oleaceae, and Plantaceae. Generally speaking, verbascoside is composed of caffeic acid and hydroxytyrosol through ester and glycosidic bonds, and its sugar part is composed of rhamnose and glucose. Experiments have shown that verbascoside undergoes multiple hydrolysis processes in the gastrointestinal tract before being absorbed into the blood, and then undergoes further phase I (redox) and / or phase II (glucuronic acid, sulfuric acid, methylation) metabolism, so Oral bioavailability of verbascoside in rats is low. Accordi...

AI Technical Summary

Problems solved by technology

Experiments have shown that verbascoside undergoes multiple hydrolysis processes in the gastrointestinal tract before being absorbed into the blood, and then undergoes further phase I (redox) and / or phase II (glucuronic acid, sulfuric acid, methylation) metabolism, so Oral bioavailability of verbascoside in rats is low

At present, there is no application report of verbascoside in the preparation of drugs or health products for preventing or treating diabetic kidney damage

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