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Application of AS1842856 in preparation of medicine for preventing and/or treating diabetic kidney disease

A technology for diabetic nephropathy and drugs, applied in the field of medicine, can solve serious side effects, cannot prevent development, restrictions and other problems

Active Publication Date: 2021-02-23
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no effective treatment for DKD. Studies have shown that only angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARBs) can delay the progression of diabetic nephropathy to a certain extent, but they still cannot prevent it. develop, and can have serious side effects—including cough (for ACE inhibitors) and severe hyperkalemia, which often limit their use
There is no report on the application of this compound in the prevention and / or treatment of diabetic nephropathy

Method used

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  • Application of AS1842856 in preparation of medicine for preventing and/or treating diabetic kidney disease
  • Application of AS1842856 in preparation of medicine for preventing and/or treating diabetic kidney disease
  • Application of AS1842856 in preparation of medicine for preventing and/or treating diabetic kidney disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1. Effect of AS1842856, a selective inhibitor of FOXO1, on renal function in diabetic mice.

[0029] 1. Experimental materials

[0030] 1. Reagents

[0031] Creatinine detection kit (Nanjing Jiancheng Bioengineering Research Institute Co., Ltd.), urea nitrogen detection kit (Nanjing Jiancheng Bioengineering Research Institute Co., Ltd.), albumin detection kit (Nanjing Jiancheng Bioengineering Research Institute Co., Ltd.).

[0032] 2. Instrument

[0033] Fully automatic microplate reader (Thermo Fisher), desktop high-speed refrigerated centrifuge (Eppendorf).

[0034] 3. Experimental animals

[0035] C57BL / 6 mice aged 8-10 weeks, weighing 20-25 g, male, were purchased from the Department of Experimental Animal Science, Peking University Health Science Center.

[0036] 2. Experimental method

[0037] 1. Animal grouping and feeding

[0038] After 5 days of adaptive feeding, the animals were randomly divided into normal control group (n=10), diabetes model gr...

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PUM

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Abstract

The invention discloses novel application of an FOXO1 selective inhibitor AS1842856. The novel application of the AS1842856 (formula I) provided by the invention is the application of the AS1842856 inpreparation of a medicine for preventing and / or treating the diabetic kidney disease. Pharmacodynamic experiments in the invention prove that: by applying AS1842856, the levels of serum creatinine and blood urea nitrogen in diabetic kidney disease injury can be obviously reduced; infiltration of kidney tissue macrophages is inhibited; and the application prospect in the aspect of kidney protection is good.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a FOXO1 selective inhibitor AS1842856 in the preparation of drugs for preventing and / or treating diabetic nephropathy. Background technique [0002] Diabetic kidney disease (DKD) is a common chronic microvascular complication of diabetes and the main cause of end-stage renal disease (ESRD), occurring in 30% of patients with type 1 diabetes and 40% of patients with type 2 diabetes Diabetic nephropathy. However, so far there is no effective treatment for DKD. Studies have shown that only angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARBs) can delay the progression of diabetic nephropathy to a certain extent, but they still cannot prevent it. develop, and can be associated with serious side effects—including cough (for ACE inhibitors) and severe hyperkalemia, which often limit their use. Therefore, it is of great signif...

Claims

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Application Information

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IPC IPC(8): A61K31/47A61P3/10A61P13/12
CPCA61K31/47A61P3/10A61P13/12
Inventor 铁璐李学军刘倩史运迪
Owner PEKING UNIV
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