34 results about "Acute alcohol" patented technology

The invention discloses a composition with anti-alcoholic and liver-protecting effects, a preparation method and application thereof. It is composed of kudzu root, Hovenia dulcis, hawthorn, chrysanthemum, black plum, reed root, alanine, and glutamine in proportion, and can be processed into various products with the effect of relieving alcohol and protecting the liver. The composition has the functions of improving human body's tolerance to alcohol, preventing acute alcohol poisoning, assisting the treatment of alcoholic liver damage and alcohol allergy, and the like. In addition, the present invention also relates to a method for making the composition into various foods and medicines.

The invention provides an anti-intoxication, alcohol-expelling and liver-protection preparation which has the functions of anti-intoxication, alcohol-expelling and auxiliary protection on alcoholic liver injury. The preparation consists of the following raw materials: 20-50 parts of vine tea, 5-15 parts of galangal, 10-40 parts of mung beans and 10-40 parts of poria cocos. The vine tea contains a great amount of flavonoid substances, and the dihydromyricetin in the vine tea has special effects in removing toxicity in alcohol, preventing alcoholic liver and fatty liver, inhibiting liver cell deteriorate, reducing the morbidity of liver cancer and protecting the liver. The galangal is acrid and hot in property, can enter the spleen and stomach channels, has the functions of eliminating cold to stop pain and warming the middle energy and stopping throwing and has a certain alcohol-expelling function, and moreover the flavonoid substance galangin in the galangal has a protection function on acute alcoholic liver injury. The poria cocos has the effects of clearing damp and promoting dieresis, tonifying spleen and quieting the heart, can promote the alcohol in bodies to discharge out along with urine, and is beneficial to sobering up. The mung beans have the effect of clearing away heat and toxic materials, can effectively relieve the symptoms of dizziness and unclear speaking after drinking alcohol, and furthermore has the pharmacologic action of protecting the liver and the kidney.

The present invention provides methods for reducing alcohol drinking behavior in humans and treating acute alcohol poisoning through the use of neutral or negative modulating agents of the neurosteroid sites on GABAA receptors. These agents avoid the unwanted side-effects of opiate antagonists and displays specificity toward the neurosteroid binding sites on GABAA receptors.

The invention provides a food, a health-care product or a medicinal composition, which is a preparation prepared from the following bulk drugs in parts by weight: 10-12 parts of hawthorn, 6-9 parts of medlar, 4-6 parts of polygonatum kingianum, and 12-15 parts of dandelion. The hawthorn and other totally four medicines are used in a combined manner to play the synergetic effect, so that the medicine / health-care food provided by the invention has a remarkable liver-protecting effect, can be used for remarkably improving liver injury, in particular the pathological performance of acute alcohol liver injury, and provides a new choice for clinical administration.

The invention relates to a composition having a function of relieving alcoholism to protect liver. The composition is composed of the following components of, by weight, 10-90 parts of vine tea and 10-90 parts of blueberry. A preparation method mainly comprises the following steps of (1) mixing vine tea and blueberry according to a prescription proportion, extracting by using a water decoction extraction method, an ultrasonic extraction method or an ethanol refluxing extraction method to obtain an extract; and (2) adding conventional auxiliary materials to the extract obtained from the step (1) and mixing according to a conventional method to obtain a needed health-care product. The composition can enhance tolerance of a human body to alcohol, prevent acute alcohol alcoholism and assist to treat alcoholic liver damage and alcoholic allergy. The composition is stable in quality, easy to carry, convenient for use, small is dosage and rapid in curative effect.

The invention disclosed herein includes nanocomplexes that are designed include enzymes that have complementary functional attributes and methods for using these nanocomplexes. Illustrative examples include nanocomplexes that comprise both an alcohol oxidase enzyme as well as a catalase enzyme. These nanocomplexes can be used in methods designed to lower blood alcohol levels in vivo, and / or to break down the toxic byproducts of alcohol metabolism. Consequently these nanocomplexes can be used to treat a variety of conditions resulting from the consumption of alcohol, including for example, acute alcohol intoxication.

The invention discloses a drug for preventing and treating the alcoholic liver disease. Active ingredients of the drug comprise lactobacillus rhamnosus liquid supernatant and vitamin E, and preferablytanshinone IIA sodium sulfonate is added. Based on the modern pathological study, the drug is combined with the theory of traditional Chinese medicine; according to the curative effect, the drug hasthe effects of restoring intestinal barrier damages caused by alcohol, improving oxidization resistance of livers, improving cellular swelling and fatty degeneration of the livers, relieving fibrous septum, and the like, and has obvious prevention and treatment effect on acute alcoholic liver injury and alcohol hepatic fibrosis.

The invention discloses application of Ligustrum robustum (Roxb.) Blume total flavonoids in the technical field of preparation and application of traditional Chinese medicinal materials. LD50 of Ligustrum robustum (Roxb.) Blume total flavonoids is larger than 500 mg / kg, it is proved that the Ligustrum robustum (Roxb.) Blume total flavonoids are low in toxicity, toxicity of alcohol on gastrointestinal tracts and nerves of mice can be effectively improved, and the Ligustrum robustum (Roxb.) Blume total flavonoids have a certain pharmacodynamic effect and safety for preventing acute alcoholic liver injury mice.

The invention belongs to the technical field of medicines, relates to a pharmaceutical composition of a naloxone hydrochloride injection and a preparation method of pharmaceutical composition, and particularly relates to a pharmaceutical composition of a naloxone hydrochloride injection. The pharmaceutical composition comprises naloxone hydrochloride, and particularly comprises naloxone hydrochloride, saccharides, organic acid and injection water. The naloxone hydrochloride in the pharmaceutical composition is added to the composition in a form of 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-pyran-6-methadone hydrochloride dehydrate; the saccharides are selected from one or more of the following components: mannitol, sorbitol, lactose, maltose, glycine, mycose, glucose and the like. The pharmaceutical composition disclosed by the invention can be used after opioid compound anaesthesia to resist respiratory depression caused by the medicine and prompt patients to revive, is used for respiratory depression caused by excessive opioids and complete or partial reversion of the opioids, is used for saving acute alcohol poisoning, and is used for diagnosing excessive acute opioids.

The present invention discloses a formula of health-care food having an auxiliary protection function for gastric mucosal injury. The health-care food comprises dunaliella salina powder, a radix puerariae extract and a radix astragali extract. Advantages are as follows: an animal experiment proves that the health-care food can obviously reduce a total score of a general score of gastric mucosal acute alcohol injury in rats and a total score of a histopathological observation of the gastric mucosal acute alcohol injury in the rats. A human body feeding trial proves that the feeding trial of soft capsules prepared by the formula can obviously reduce a clinical symptom score and a score of tenderness beneath the xiphoid process, the tenderness beneath the xiphoid process can be effectively relieved, and an improvement efficiency is 89.5%. The dunaliella salina powder is a new food raw material, the radix puerariae extract and radix astragali extract are medicinally and edibly homogenous raw materials, and the raw materials can all be used for the health-care food. The animal experiment and human body feeding trial prove that the prepared soft capsules are safe and reliable, can be taken for a long time, are free of toxic or side effects, do not show allergies and other adverse reactions, and do not cause damages to other organs of human body.

The invention relates to a roxburgh rose active extract with an auxiliary protection effect on acute alcoholic liver injury. The active extract is prepared by the following steps: performing alcohol reflux extraction on freshly squeezed roxburgh rose pomace or roxburgh rose fruits, filtering, concentrating to remove ethanol, adding water to disperse water insoluble precipitate, filtering, sequentially washing the precipitate with water and petroleum ether or n-hexane, removing water-soluble substances and grease, and drying. The active extract is rich in triterpene and flavone components, has an auxiliary protection effect on acute alcoholic liver injury, can be used for preparing medicines and auxiliary medicines for auxiliary protection of acute alcoholic liver injury or used as a healthy food additive, and has relatively high application value and market prospect. The roxburgh rose extract has important significance in high-value utilization and sustainable development of the rosa roxburghii tratt fruit industry, an intermediate or additive raw material is provided for medicines or health-care foods for auxiliary protection of acute alcoholic liver injury, and the preparation method is simple, easy to implement, low in cost and capable of realizing industrial production.

The invention discloses a traditional Chinese medicine formula capable of fast lowering blood alcohol concentration by taking before drinking. The formula mainly takes the theory of traditional Chinese medicine as a guide and is different from the traditional thinking of dealcoholic prescription; atractylodes, liquorice and hawthorn have the effects of strengthening spleen and promoting the circulation of qi; and schisandra chinensis, Dark Plum fruit and myrobalan have the effects of combining acid and sweet medicines to reinforce and nourish yin and converge liver. The formula nourishes the liver, strengthens blood and regulates spleen and stomach and nourishes yin and converges liver simultaneously, therefore the poison gas of alcohol cannot pass the spleen and stomach to damage the liver; and simultaneously, the alcohol poison which enters the body boosts metabolism. Through preliminary clinical trials, the peak concentration after taking acute alcohol can be obviously lowered and alcohol metabolism lag cannot occur. The formula comprises ingredients as follows: 3 to 30 g of hawthorn, 3 to 30 g of Dark Plum fruit, 3 to 30 g of schisandra chinensis, 3 to 30 g of atractylodes, 3 to 30 g of myrobalan and 3 to 30 g of liquorice.

The invention discloses the new use of garlic oil, namely the application of the garlic oil in preparing the medicaments used for resist acute alcoholic fatty liver. 50 to 200 mg of garlic oil is contained in the medicaments resisting acute alcoholic fatty liver caused by alcohol of 4.8g / kg.bw per kilogram of body. The garlic oil is taken orally, and is taken two hours prior to drinking. Before the garlic oil is taken, the garlic oil can be diluted with corn oil. Proven through experiments on mice, the garlic oil can significantly reduce the liver index, sera TG, liver TG, and inhibit liver MDA l from rising caused by ethano, and can increase the content of GSH in the liver, which has the function of resisting acute alcoholic fatty liver. The garlic oil can be used for preparing medicaments for resisting acute alcoholic fatty liver, and establishes a new application way for preventing alcoholic hepatopathy.

The invention provides an application of rosustat in a medicine for inhibiting acute alcoholic fatty liver. Roxasstat can significantly inhibit liver injury and lipid accumulation caused by acute alcohol. According to the mechanism, rosustat plays a role in inhibiting mouse liver lipid accumulation mainly by regulating and controlling the expression of lipid synthesis key genes. The medicine is expected to become an effective medicine for clinically treating the alcoholic fatty liver.

The invention discloses a medicine for resisting acute alcohol-induced hepatic injury and application thereof. The medicine is prepared from a 50%-95% ethanol extracting part of lagotis brachystachya and a 50%-95% ethanol extracting part of lagotis brevituba. A pharmacological experiment shows that the lagotis brachystachya extract can be used for remarkably reducing levels of ALT, AST, TC, TG, TNF-alpha and NF-kB in mouse serum with the acute alcohol-induced hepatic injury and can also be used for remarkably reducing the level of MDA in liver homogenate and remarkably improving the levels of GSH and SOD; the lagotis brevituba extract can be used for effectively reducing the levels of the ALT, the AST, the TC, the TG, the TNF-alpha and the NF-kB in the serum and can also be used for remarkably reducing the level of the MDA in the liver homogenate and effectively improving the level of the GSH and the SOD; and the lagotis brachystachya extract and the lagotis brevituba extract can be used for remarkably lowering the expression of the TNF-alpha in liver tissues. The lagotis brachystachya extract and the lagotis brevituba extract can be used for preparing the medicine for resisting the acute alcohol-induced hepatic injury, and development and application prospects are relatively good.

The invention relates to application of Wangshi Baochi pills in preparation of a medicine for preventing and / or treating alcoholic liver injury, and belongs to the technical field of medicines. The application of the Wangshi Baochi pills in preparation of the medicine for preventing and / or treating alcoholic liver injury is provided, and researches find that the Wangshi Baochi pills can remarkably shorten the sobering time of drunken mice and reduce the levels of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase in serum of acute alcoholic liver injury modeling mice, can significantly improve the pathological change of liver tissue of the acute alcoholic liver injury modeling mice, can significantly reduce the expression of active oxygen in the liver tissue of the acute alcoholic liver injury modeling mice, and can significantly improve the activity of superoxide dismutase and the level of glutathione in the liver tissue of the acute alcoholic liver injury modeling mice, and in addition, the Wangshi Baochi pills can increase the expression of quinone oxidoreductase in liver tissue of the acute alcoholic liver injury modeling mice and have a good alcoholic liver injury relieving effect.

The invention discloses a preparation method of a plant functional protein and application of the plant functional protein in protection of acute alcoholic liver injury, and belongs to the technical field of functional materials. Natural defatted wheat germ powder is used as a raw material to prepare wheat germ globulin through salt extraction, and the wheat germ globulin can effectively reduce the increase in liver indexes, spleen indexes and kidney indexes caused by acute alcohol stimulation, reduce the levels of total cholesterol and triglycerides in serum and play a role in protecting the liver, improve the content of glutathione in the liver and the activity of superoxide dismutase, reduce the content of malondialdehyde, improve liver oxidative stress caused by alcohol, relieve the degree of hepatocyte necrosi and play a protective effect on acute alcoholic liver injury. Compared with the existing anti-alcohol and liver-protecting medicine, the wheat germ globulin disclosed by the invention is safer and more effective, has no toxic or side effect, and obviously improves physiological and biochemical abnormalities caused by alcohol. The wheat germ globulin has considerable development and application values in the aspect of improving the acute alcoholic liver injury, and has a wide market application prospect.

The invention relates to an application of an NAD+ supplement in preparation of a medicine for treating, preventing or improving acute alcoholic liver injury, and provides an application of the NAD+ supplement in preparation of a medicine for improving alcohol tolerance and an application of the NAD+ supplement in preparation of a medicine for treating, preventing or relieving alcohol hangover symptoms. Experiments prove that the effect of treating, preventing or improving the acute alcoholic liver injury is achieved by increasing the NAD+ concentration of a patient through administration of the dietary supplement and / or the pharmaceutical composition, the liver is helped to recover from liver function damage caused by harmful factors such as alcohol, hangover can be eliminated, and the hangover symptom can be treated, prevented and relieved.

The invention discloses a novel application of lobed kudzu vine flower micromolecules to regulation of alcohol-dependent behaviors, provides a basis for the treatment of alcohol dependence by the lobed kudzu vine flower micromolecules, discloses an application of the lobed kudzu vine flower micromolecules in reducing relative drinking amount and alcohol preference in a withdrawal reaction period, discloses an application of the lobed kudzu vine flower micromolecules in reducing alcohol sensitivity and acute alcohol tolerance, and further discloses an application of the lobed kudzu vine flower micromolecules in improvement of long-term alcohol tolerance. It is determined that the lobed kudzu vine flower micromolecules can remarkably regulate the alcohol dependence behavior and have the protection effect on alcohol-caused body damage; it is determined that the lobed kudzu vine flower micromolecules play a role in treating alcohol dependence through 'multi-component, multi-channel and multi-target'; it is determined that puerarin, daidzein and daidzein have the effects of adjusting the alcohol dependence behavior and treating alcohol dependence.

The invention provides a medicine composition for preventing and / or treating alcoholic stomach injury. The medicine composition comprises berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin. The invention provides an application of a drug combination of berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin in a drug for preventing and / or treating alcoholic stomach injury. Research finds that the pharmaceutical composition can significantly improve pathological changes of stomach tissues in an acute alcohol stomach injury rat model, can significantly improve functional indexes (improving superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) and gastrin (GAS) content) in serum of acute alcohol injury modeling rats, can reduce indexes of inflammatory factors (IL-1, iNOS and TNF-alpha), and can significantly reduce inflammatory factors (IL-1, iNOS and TNF-alpha) in serum of the acute alcohol injury modeling rats. The gene expression and the protein expression of inflammatory factors (IL-1, IL-6 and TNF-alpha) in stomach tissues are reduced, and a good effect of relieving the alcoholic stomach injury is achieved.

The present invention provides the uses of 5-methyltetrahydrofolate and its composition. The 5-methyltetrahydrofolate or its composition is used to treat, relieve or prevent diseases or symptoms caused by acute alcohol intoxication and chronic alcohol intoxication. The injuries or diseases caused by the acute alcohol intoxication include: headaches caused by drinking, negative emotions or depression caused by drinking, and hangover symptoms after drinking. The injuries or diseases caused by the chronic alcohol intoxication include: alcoholic fatty liver, central nervous system (CNS) inflammation, etc.

The invention belongs to the field of medical technology and health care products, and particularly relates to a novel application of rendan mini-pill traditional Chinese medicine composition in alleviation of hangover or treatment of alcoholic liver injury. The invention finds that the rendan mini-pill traditional Chinese medicine composition has a good hangover alleviating effect, and can prolong the alcohol tolerance time of drunken mice. The invention also finds that the rendan mini-pill traditional Chinese medicine composition has prevention and treatment effects on alcoholic liver injury, can reduce the weight and liver index of mice with acute alcoholic liver injury, and effectively improves the liver injury and ALT and AST activity of serum of the mice with alcoholic liver injury;and meanwhile, the expression of alcohol metabolism key enzyme cytochrome P450 2E1 (CYP2E1) protein can be obviously reduced.

The invention discloses granules capable of relieving alcoholism and protecting the liver. The granules capable of relieving alcoholism and protecting the liver comprises the following raw materials in parts by weight: 20-30 parts of dry eggplant stem cell powder, 0.6-0.8 part of flavorings, 60-90 parts of excipients, and 0.2-0.6 part of wetting agent. The invention further discloses a preparation method of the dry eggplant stem cell powder. Compared with prior art, the granules have the following beneficial effects: the dry eggplant stem cell powder enriched with alcoholism-relieving components is utilized, and black-bone chicken protein peptides and syringic acid are combined, so that the prepared granules are capable of preventing acute alcohol intoxication as well as obviously prolonging time to drunk and shortening alcoholism-relieving time; and the alcoholism-relieving effects of the granules are obvious. The granules are safe, free of side effects, and convenient to carry and eat.

The invention discloses a composition with anti-alcohol and liver-protection effects, and a preparation method of the composition. The composition with the anti-alcohol and liver-protection effects comprises, by weight, 20-40 parts of tilapia skin polypeptides, 10-20 parts of sarmentosin, 10-20 parts of a mulberry concentrated solution, and 5-15 parts of carboxymethyl chitosan microspheres. All the components in the composition work jointly and compatibly so that the anti-alcohol and liver-protection effects can be achieved rapidly and synergistically. The invention further provides a productwith the anti-alcohol and liver-protection effects on the basis of the composition. By adopting the composition with the anti-alcohol and liver-protection effects, the drunkenness rate of a mouse suffering from acute alcohol intoxication can be significantly reduced, sleep maintenance time and sober-up time of the mouse are shortened, and a drunkenness latent period of the mouse is prolonged; andmeanwhile, abnormal increases of levels of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase in mouse serum are inhibited, the significant liver protection effect is shown,and therefore the composition has wide application value in preparing anti-alcohol and liver-protection products.